Possible role of contaminating endotoxin in radiographic contrast media reactions.
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Blood Coagulation Disorders↗
Biomedical subjects
D Fumarola
Publications and source records attributed to D Fumarola.
[1st experiences on the protective effect of Limulus polyphemus amebocyte lysate in the endotoxic shock in the rat].
The injection in the peritoneum of Limulus amebocyte lysate at the same time of inoculation of lethal dose of E. coli LPS is able to protect the rats against endotoxin lethality.
Animals↗
Endotoxemia detected by Limulus assay in severe malnourished children. Plasma effects on leucocyte migration: preliminary investigations.
The Authors have examined 10 cases of severe malnourished children (7 cases of kwashiorkor, 2 cases of marasmus, 1 case of marasmic kwashiorkor). Experiments were carried in order to detect endotoxemia by means of Limulus test, bacteremia with blood cultures and possible effects of plasma on leucocyte migration by Leucocytes Migration Agarose Test (LMAT). The relationship between severe malnutrition, endotoxemia and leucocytes migration has been discussed.
Arthropods↗
[Possible endotoxin contamination of erythropoietin preparations].
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Drug Contamination↗
[Endotoxic contamination of biological products (ribosomal vaccines, viral vaccines and interferon)].
The A.A. have examined by the Limulus assay the possible endotoxin contamination in some biological products (ribosomal vaccines, viral vaccines, interferon). While the preparations of influenza vaccines and a partially purified fraction of ribosomal vaccine from Pseudomonas aeruginosa exhibit a gelation of lysate with high levels of endotoxin, rubeola vaccines, interferon and a purified fraction of ribosomal vaccine, presented a negligible amount of endotoxin. The results are discussed with the aim to examine the possible role of contaminating endotoxin in the mediation of some adverse effects and of the unsuspected extrinsic adjuvant activities developed in clinical and experimental use of these preparations.
Bacterial Vaccines↗