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D G Clayton Jones

Publications and source records attributed to D G Clayton Jones.

7 recordsLinked to original sources
PubMed1989

Variable adaptation of molecular mechanisms in relation to the use of autologous striated muscle to augment myocardial function.

Significant recent advances in molecular biology and protein biochemistry have allowed the examination of muscle function at gene and protein level. This article reviews the variable adaptation of molecular mechanisms in striated muscle. The adaptation and transformation of fast skeletal muscle in response to chronic electrical stimulation may have considerable importance in relation to the use of autologous skeletal muscle to augment myocardial function.

Adaptation, Biological↗
PubMedDate not supplied

Early experience using a purpose-built pulse train stimulator for cardiac assistance with skeletal muscle.

We have developed and evaluated a prototype external pulse train stimulator for use with a new technique of circulatory assistance. This involves the use of skeletal muscle (latissimus dorsi) wrapped around the thoracic aorta as an entirely autologous extra-aortic counterpulsation system. The stimulator has been successful in initiating both muscle contraction at the desired part of the cardiac cycle (diastole) and the necessary fibre-type transformation required for long-term work (fatigue resistance). The background to the development of the stimulator and the early haemodynamic results are described in this paper. The evaluation of the prototype design and the areas for future development are discussed.

Animals↗