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Biomedical subjects

D G Gilmour

Publications and source records attributed to D G Gilmour.

15 recordsLinked to original sources
PubMed1979

Dural dimpling in the dog.

Indentation of the dura has been proposed as the cause of subatmospheric pressure in the extradural space, but has never been demonstrated directly in humans. In this study, radiographs have been produced showing dimpling of the dura by a needle tip lying in the extradural space in the dog. Pressure tracings demonstrate that advancement of the needle tip produces a progressive decrease in extradural pressure, and observations made using an image intensifier have confirmed that the pressure changes are proportional to the degree of dural indentation.

Anesthesia, Epidural↗
PubMed1978

Movement of the critically ill within hospital.

Critically ill patients can be safely moved within hospital using a mobile intensive care unit (MICU). The MICU allows the critically ill to benefit from specialised investigation and treatment they might otherwise be denied. The MICU in use at the Western Infirmary, Glasgow is described and its merits outline in the light of clinical experience gained over a twelve month period.

Adult↗
PubMed1976

Lymphocyte-differentiating hormone of bursa of fabricius.

Induction of early lymphocyte differentiation was studied in vitro in fractionated bone marrow cells of newly hatched chickens, with alloantiserums to identify newly differentiated B cells (Bu-1+) and T cells (Th-1+). Thymus extract induced selective T cell differentiation; the activity of the extract corresponds to that of thymopoietin. Bursal extract induced both B cell and T cell differentiation, but at lower concentrations B cell differentiation was always greater. This activity is ascribed to a lymphocyte-differentiating hormone of the bursa of Fabricius, for which the name bursopoietin is suggested.

Animals↗
PubMed1976

Exercise tests before and after heart valve replacement.

A simple progressive exercise test was performed before and after operation on five subjects undergoing mitral valve replacement and on five subjects undergoing aortic valve replacement. The responses of heart rate and ventilation were related to work rate )kilopond metres/min). The patients were also assessed clinically by the New York Heart Association grading and radiologically before each exercise test. The clinical grading was shown to be a poor guide to observed exercise tolerance, as the improvement noted in symptoms was not matched by the objective measurement of working capacity. Only two patients had normal exercise tolerance after surgery, although six of the ten patients claimed that they had no exertional dyspnoea after operation. The changes in simple ventilatory function tests before and after operation were generally small. We suggest that measurements of exercise tolerance before and after operation should be an essential part of heart valve replacement surgery.

Adult↗
PubMed1975

Lymphoid leukosis in chickens chemically bursectomized and subsequently inoculated with bursa cells.

Lymphoid leukosis (LL), a neoplasm of the bursa-dependent lymphoid cells of the chicken, was induced by Rous-associated virus-1 in susceptible chickens. Cyclophosphamide (CY), which destroyed the lymphoid elements of the bursa of Fabricius and abrogated humoral immunity, prevented LL. Concomitantly, osteopetorosis and other neoplasms increased. Transfer of bursa cells from chickens into CY-treated hatchmates restored immune competence. Birds whose B-cell functions were reconstituted died of LL and were less likely to die of osteopetrosis and other neoplasms than were CY-treated chicks. These results suggested that the bursa cell transferred into the CY-treated chicks were the target cells for lymphoid leukosis transformation.

Animals↗
PubMed1975

Migratory patterns of B lymphocytes. III. Inhibition of splenic follicular localization of transferred chicken bursa cells by preincubation with anti-Ig-1.

Homing of 3-H-adenosine-labeled bursa cells to follicles in the chickens spleen was greatly reduced by prior incubation of the transferred cells with rabbit anti-chicken-immunoglobulin sera. This effect was transient, being present 6 hr after cell transfer but gone by 18 hr, when incubation was at 0 degreesC without complement. The inhibition persisted until at least 18 hr after incubation at 37 degrees C with complement.

Absorption↗