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Biomedical subjects

D G Griffin

Publications and source records attributed to D G Griffin.

4 recordsLinked to original sources
PubMed2004

A review of the heritability of idiopathic nephrolithiasis.

Familial aggregations of nephrolithiasis were already noted in the early 19th century and over the intervening years there has been gradual progression in classifying the familial forms of nephrolithiasis. To date, there are at least 10 different monogenic conditions where those affected have a predisposition to nephrolithiasis. However, all of these rare conditions probably account for less than 2% of renal stone formers. This review, rather than considering these clearly defined disorders, concentrates on research into the broad band of stone formers who have a propensity to nephrolithiasis without an obvious discrete genetic basis.

Calcium↗
PubMed2001

Analysis of pesticide gas cartridges.

Charcoal and sodium nitrate, the active ingredients in pesticide gas cartridges, are quantified via carbon analysis and ion chromatography, respectively. Linearity was excellent (R(2) > 0.995) over a range consisting of 50-150% of the target concentration for both ingredients. The coefficient of variation for the replicate analyses of gas cartridges over multiple days was <4% for both analytes. Using the results from the analysis of two batches of gas cartridges, theoretical populations were modeled and used to determine practical sampling strategies to support a quality control program for a gas cartridge manufacturing operation. This modeling indicates that the analysis of three cartridges from each of five different lots would produce mean values for both active ingredients that are within 5% of the true mean >99% of the time.

Carcinogens↗
PubMed1990

B virus (Herpesvirus simiae) infection in humans: epidemiologic investigation of a cluster.

A cluster of four cases of symptomatic B virus infection in humans occurred in Pensacola, Florida, in March 1987. Three cases occurred in persons who worked with monkeys at a research facility, and the fourth resulted from apparent autoinoculation through use of a nonprescription skin cream. Contact tracing identified 159 persons who may have been exposed to B virus (21 had been exposed to monkeys at the facility and 138 had been exposed to one or more of the case-patients), but no further cases were identified. Comparisons of restriction endonuclease patterns from B virus isolates linked two of the three cases in monkey handlers to one clinically ill monkey and the other to a second, healthy monkey. Three risk factors for human infection were identified: nonuse of mechanical or chemical restraints for monkeys before handling, nonuse of available protective gear, and direct viral inoculation through the application of a topical medication.

Acute Disease↗