Management of hemorrhagic events in patients receiving anticoagulant therapy.
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Anticoagulants↗
Biomedical subjects
D G Love
Publications and source records attributed to D G Love.
Massive thromboembolic stroke and death after fibrinolytic therapy of St. Jude prosthetic mitral valve thrombosis: documentation by transthoracic Doppler echocardiography.
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Aged↗
Layperson CPR--are we training the right people?
A case-control study was undertaken to examine differences in the extent of cardiopulmonary resuscitation (CPR) training among family members of patients with and without coronary heart disease. There were no significant differences in the proportion of family members of patients with coronary disease (22.0%) who had ever taken a CPR course compared to family members of patients seen in a primary care clinic (25.6%) or in randomly selected neighborhood controls (28.7%). Family members of patients with coronary disease, however, had not only taken fewer CPR courses but had taken these courses considerably further in the past than had respective comparison groups. Moreover only 9% of these family members had taken CPR due to their family member's coronary disease.
Adult↗
Platelet size does not correlate with platelet age.
The relationship between platelet size and in vivo aging was investigated in the baboon using size-dependent platelet subpopulations separated by counterflow centrifugation. The separation characteristics, size, lactate dehydrogenase (LDH) activity, and dense-body content of the baboon platelet subpopulations were similar to those previously observed in studies of human platelets. Three independent labeling techniques were used: (1) in vivo labeling with 75Se-methionine, (2) in vitro labeling with 51Cr, and (3) in vivo labeling with 14C-serotonin. Maximal incorporation of all three labels showed a close correlation between the mean platelet volume (MPV) of each fraction and the platelet radioactivity. The onset of incorporation and rate of accumulation of 75Se-methionine were comparable in all fractions when corrected for differences in volume, suggesting that platelet size heterogeneity was present from the time of release of the platelets from the bone marrow. Survival studies using 51Cr and 14C-serotonin showed no translocation of the label from one fraction to another in the circulation over time. In vivo survival values for the three radionuclides showed a slight but significant correlation between the lifespan and the MPV of the fractions. The data suggest that large platelets were not younger platelets, but rather platelets with a longer life-span. Platelet size heterogeneity is the result of production factors in the bone marrow and not maturation in the circulation.
Animals↗