PubMed Health⌕ Search

Biomedical subjects

D G MacGregor

Publications and source records attributed to D G MacGregor.

21 records · Page 2Linked to original sources
PubMed1992

Prevention of kainate-induced excitotoxicity by a purine analogue.

The effect of a systematically administered adenosine analogue upon neuronal damage induced by kanic acid has been examined using the binding of a peripheral benzodiazepine receptor ligand as a marker for the gliosis following neuronal death. Intraperitoneal (i.p.) injections of R-phenylisopropyladenosine (R-PIA), at a dose of 100 micrograms kg-1 or 25 micrograms kg-1 reduced substantially the hippocampal neurotoxicity induced by intraperitoneal kainate 100 mg kg-1. The effect of R-PIA was prevented by 8-phenyl-theophylline, confirming the involvement of a purine P1 receptor.

Animals↗
PubMed1989

Perception of risk in automotive systems.

Thirty subsystems constituting a functioning motor vehicle, including brake, steering, suspension, engine, electrical, and fuel systems, were evaluated by individuals on a set of risk characteristic scales. These included overall vehicle riskiness, manufacturer's anticipatory knowledge of system defects during vehicle design, likelihood of severe consequences in the event of system failure, controllability of the vehicle, and observability of impending failure. An analysis of the resulting judgments revealed two composite factors, one representing the controllability of consequences and the other representing observability. Both factors were highly related to judgments of risk, desire for risk regulation, and anticipated recall compliance. A comparison of risk judgments with accident data suggested that for some vehicle systems, particularly those serving a communication function in the driving task, drivers may underestimate the actual risk they face when system performance has degraded.

Adult↗