Biomedical subjects

D G Rice

Publications and source records attributed to D G Rice.

At least 19 recordsLinked to original sources

PubMed1986

Combination vincristine and VP-16-213: evaluation of drug sequence.

The combination of vincristine and VP-16-213 has been found to have synergistic antitumor activity in a murine system in vivo when the sequence of drug administration was vincristine followed by VP-16-213. To investigate the potential influence of drug scheduling on this synergistic combination, the reverse sequence of drug administration was evaluated. DBA/2 mice were inoculated with 10(6) P-388 murine leukemia cells, after which saline only, VP-16-213 only, vincristine only, or VP-16-213 followed at various time intervals by vincristine, were administered. Probable cure (survival greater than 60 days) was observed in 0/20, 0/20, 0/120, and 46/115 (40%), respectively (p less than 0.001). The proportion of animals attaining probable cure was greatest in the group receiving vincristine 4-72 hours after VP-16-213 (40-50%). Similar results had been obtained previously with the reverse drug sequence. In this animal model, the synergistic antitumor activity of vincristine and VP-16-213 does not appear to be schedule-dependent with respect to the sequence of drug administration.

Animals↗

PubMed1980

Life events as predictors of academic performance.

As part of a larger study, information was obtained about the life events which had occurred in the one-and-ten-year periods prior to entrance into a study of 169 students at a large midwestern university. Different methods of calculating life change were utilized, and these measures were correlated with the students' subsequent grade point averages over the next three years. Results demonstrated a significant negative association between life change and academic performance for the first-and second-but not for the third-year grades. Further analysis suggested a threshold effect since the detrimental impact of life change appeared evident only after the occurrence of about 12 events in the one-year time period. Life change also was implicated as a factor in severe academic difficulty resulting in the initiation of formal academic sanctions. Specific events which occurred in excess among the poorer performing students also were reported.

Achievement↗

PubMed1977

Marital therapy in prison: one-partner 'couple therapy'.

The intent of this article is, first, to describe some currently available means of strengthening marital and family ties for the incarcerated offender, and to point out the inherent limitations of these processes. Second, we will describe common reactions of inmates to marital crises, especially impending divorce. Third, we will make some comments and recommendations about the conduct of 'marital therapy' when the therapist has access to only one spouse or partner. Inefficient and dysfunctional as such an approach may sound to the therapist accustomed to working with couples 'on the streets,' it is often the only alternative available to the correctional mental health professional when the imprisoned marital partner is in a state of acute pain, with both crisis intervention and follow-up treatment critical.

Communication↗

PubMed1977

The intensive care unit: social work intervention with the families of critically ill patients.

Hospital intensive care units can be a significant practice area for social workers. Nowhere are families in more obvious crises than when faced with the life-threatening illness of a significant other who may be unresponsive and dependent on a frightening array of highly technical equipment. Using the crisis model for their intervention, social workers can significantly lessen the trauma experienced by these families. Additionally, they can develop other supportive hospital resources such as family groups and volunteer services to help meet their needs.

Adaptation, Psychological↗

PubMed1976

Genetic correlates and sex differences in Holtzman Inkblot Technique responses of twins.

Holtzman Inkblot Technique (HIT) responses of 36 monozygotic (MZ), 18 dizygotic same-sex (DZ-S) and 29 dizygotic opposite-sex (DZ-O) college student twin pairs were analyzed. MZ group twins were significantly more alike across a variety of HIT response dimensions than DZ-S or DZ-O group twins. The following variables indicated a possible significant genetic contribution to response determination: Movement, Abstract Content, Hostility, Pathognomic Verbalization and Popular Responses. DZ-O groups data (representing a high degree of control for environmental influences) indicated significant sex differences on the following variables: M less than F -- Rejection, Form Appropriateness, Anatomical Content, and Balance; F less than M -- Human Content and Popular. The results are discussed in terms of (a) comparable genetic determination studies with Rorschach responses and (b) the necessity for separate male and female norms on several HIT scored response scales.

Adult↗

PubMed1975