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Biomedical subjects

D G Scarpelli

Publications and source records attributed to D G Scarpelli.

96 records · Page 6Linked to original sources
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Estradiol receptor assays in normal and neoplastic tissues. A possible diagnostic acid for tumor differentiation.

Estradiol (E2) binding activity was studied in several normal tissues and neoplasias of humans and experimental animals. Positive E2 binding was seen in 37 percent of breast primary malignancies, 50 percent of breast cancer metastasis to other organs, and 55 percent of breast cancer metastasis to lymph nodes. Two other tumors, renal cell carcinomas and thyroid adenocarcinomas, also had a high percent of E2 binding activity. No difference was evident histologically between the tumors which were positive and those which were negative. Elevated E2 binding activity was seen in normal liver and pancreas of rats and mice as well as in an experimentally induced acinar pancreatic carcinoma of the rats. These preliminary results indicate that the measurement of estradiol receptors should be extended to other neoplasias than breast cancer, and it may give some indication about the evolution and the hormonal controls of the tumors themselves.

Adrenal Gland Neoplasms↗
PubMedDate not supplied

Recent developments toward a unifying concept of carcinogenesis.

Although considerable progress has been made toward identification of the various factors involved in the causation of cancer, little is known about how they mediate the neoplastic transformation. Recent developments in the molecular biology of tumor viruses and cancer genetics have established that normal mammalian cells contain genes sequences (oncogenes) that are homologous to those in certain oncogenic RNA viruses in mouse, rat, and chicken. These sequences are turned off or expressed at very low levels of activity in normal cells and conversely turned on in the neoplastic state where, in some instances, large amounts of a specific gene product are produced which appears to be linked to the neoplastic transformation. Oncogenes may represent the final common pathway through which chemicals, ionizing radiation, oncogenic viruses ultimately cause cancer.

Animals↗