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Biomedical subjects

D G Silva

Publications and source records attributed to D G Silva.

At least 19 recordsLinked to original sources

Diltiazem improves left ventricular systolic function following acute myocardial infarction treated with streptokinase. The Calcium Antagonist in Reperfusion Study (CARES) Group.

The role of diltiazem on left ventricular systolic function was analyzed in 101 patients with acute myocardial infarction treated with streptokinase, being obtained, for the total of the population, higher LV global ejection fraction (p = 0.022), LV regional shortening (p = 0.046) and LV global shortening (p = 0.064) for the treated group, relative to the placebo group; the p values were, respectively, 0.005, 0.009, and 0.012, for patients that achieved TIMI-3 antegrade coronary flow. It is concluded that diltiazem is useful as adjuvant to streptokinase, especially when antegrade coronary blood flow TIMI-3 is obtained.

Aged↗

Oviductal cilial phagocytosis in patients undergoing tubal reanastomosis.

Chronic salpingitis has been reported in patients undergoing reversal of sterilization. For investigation of a possible microbial etiology for this process and characterization of its ultrastructural features, segments from the midportion of the fallopian tubes of five patients who underwent sterilization reversal were studied by comprehensive tubal cultures, and light and electron microscopy. Three patients undergoing sterilization by partial salpingectomy were studied as controls. Chlamydial IgG and IgM antibody titers were performed on serum samples. No microbiologic or serologic evidence for active infection by known pathogens was found. In three of the study patients mild oviductal mural fibrosis was present. However, in two other study patients chronic salpingitis with phagocytosis of cilia by luminal macrophages was demonstrated. It is suggested that if this active process persists after tubal reanastomosis, it may result in impaired oviductal function.

Adult↗

Management of condyloma acuminatum.

This article describes an approach to the evaluation and treatment of condyloma acuminatum (anogenital warts) that is based on the results of new clinical research on the biology of the human papillomavirus. A more extensive diagnostic protocol, including routine cervicovaginal examination and Papanicolaou smear, is proposed for female patients because of the close association of genital human papillomavirus infections with cervical carcinoma. Two highly effective therapies, cryosurgery and carbon dioxide laser photocoagulation, are described and compared with older regimens. Recent developments in immunotherapy for resistant condyloma acuminatum are also discussed.

Clinical Trials as Topic↗

Histiocytosis X.

A patient with histiocytosis X had nonhealing mouth lesions. Evaluation revealed diabetes insipidus and numerous bony lesions. Electron microscopy of the mouth lesions and lymph nodes did not indicate Langerhans cells, which have frequently been described as occurring in histiocytosis X. A survey of 59 patients examined during a 20-year period at UCLA reported the presence of oral lesions in 42% of the cases and confirmed the occurrence of a wide range of clinical patterns and variations in the course of the disease.

Adolescent↗