Leptospirosis--a cause for concern?
A severe case of Weil's disease is presented. The particular relevance of this condition to the Armed Forces and Service physicians is discussed, together with methods of diagnosis.
Adult↗
Biomedical subjects
D G Sinclair
Publications and source records attributed to D G Sinclair.
Community acquired pneumonia in the Gulf.
Explore the source record for details and available documents.
Adolescent↗
Attenuation of exercise induced asthma by nedocromil sodium and sodium cromoglycate.
A randomized double blind cross over trial to compare nedocromil sodium and sodium cromoglycate with placebo in the prevention of exercise induced asthma was conducted. Twenty asthmatics received nedocromil sodium, sodium cromoglycate or placebo via metered dose inhalers on successive days 30 minutes before exercise in a randomized order. Nedocromil sodium and sodium cromoglycate gave sufficient protection (P less than 0.05) compared to placebo as assessed by the reduction in the maximum percentage fall in the forced expiratory volume in 1 second (FEV1). The protective effect of nedocromil sodium and sodium cromoglycate varied in individuals.
Administration, Inhalation↗
Recombinant DNA laboratory data manager using DBASE III+.
The use of recombinant DNA technology in clinical and research laboratories involves diverse information management functions such as keeping track of patient samples, blot membranes, polymerase chain reaction products and test results. We report here the use of a PC-based database manager (DBASE III+, Ashton-Tate) for the coordinated maintenance of these functions. We have implemented a menu driven interface, developed using DBASE's programming language, which provides a data entry and maintenance system. The system is easily learned by technologists and saves time and reduces data handling errors compared to a manual method. The system can rapidly look up data and produce customized worksheets or reports correlating all available clinical and laboratory information. We will provide a copy of the program disc to interested parties.
DNA, Recombinant↗
Intralobar pulmonary sequestration presenting as a psoas abscess.
Intralobar pulmonary sequestration is a relatively rare congenital anomaly. The commonest clinical presentation is with chronic cough, expectoration and recurrent attacks of pneumonia. An unusual presentation with a psoas abscess is reported.
Abscess↗
Metabolic intermediates and lactate diffusion in active dog skeletal muscle.
The concentration of several metabolic intermediates, blood flow (Q), oxygen uptake (VO2), and lactate release (La) were measured in the gastrocnemius muscle of anesthetized dogs. Muscle lactate concentration increased from 1.6 to 2.7 mumol/g wet wt (P less than 0.05) during 0.5-5 min of contractions at 5 twitches/s but was not different from the contralateral resting muscle at 15, 30, or 60 min. Glycerophosphate increased from 0.35 to 0.70 mumol/g wet wt (P less than 0.05) during 0.5-5 min of activity, whereas muscle pyruvate decreased from 0.09 to 0.07 mumol/g wet wt (P less than 0.05). The concentration of NAD did not change in 9 of 11 experiments during contractions, despite a 12- to 15-fold increase in La. Significant decreases in NAD were observed when Q was compromised by arterial occlusion during contractions. No demonstrable relationship existed between La and either the muscle lactate concentration or muscle-venous lactate concentration gradient. Q was positively correlated with both La and muscle lactate during the first 5-15 min of activity. We conclude that increased La or increased lactate concentration in muscle need not be associated with hypoxia and that Q has a major influence on La.
Animals↗
Suppression by corticosterone of adrenocorticotropin release from adenohypophyses incubated in Krebs-Ringer bicarbonate ultrafiltered plasma.
Explore the source record for details and available documents.
Adrenalectomy↗
Competitive nature of the intestinal transport mechanism for cobalt and iron in the rat.
Dose- and time-response studies were performed in iron-loaded and iron-deficient rats in order to define, (a) the kinetics of absorption of cobalt and iron, (b) the nature of the inhibitory effect of one metal on the absorption of the other, and (c) the effect of variations in body iron stores on these processes. The duodenum was perfused for 5-90 min with labeled solutions containing 5.0 mM iron or 5.0 mM cobalt. In iron-loaded rats, the rate of cobalt absorption was constant for 90 min whereas the rate of iron absorption fell after 30 min. In comparison to these results, the rate of absorption of both metals was increased in iron deficiency, and was more rapid in the first 30 min than in the 30-90 min period.To determine the response to varying doses of metal, we perfused duodenal loops for 30 min with 0.1-10.0 mM solutions of either iron or cobalt. In both iron-loaded and iron-deficient groups, a greater proportion of the metals was absorbed from smaller than from larger doses. When iron and cobalt were perfused together in iron-deficient animals, cobalt competitively inhibited iron absorption, and conversely, iron reduced cobalt absorption. The apparent maximum transport velocity was similar for both metals, but the affinity for cobalt was greater than iron. The results suggest that the absorption of cobalt and iron is mediated by a transport system in which two processes operate simultaneously; the first is limited largely by the concentration of available metal in the lumen of the intestine, whereas the second process depends upon the activity of a mechanism which displays saturation kinetics and competitive inhibition. The former process prevails when iron stores are replete, whereas the latter predominates when there is a need for iron, such as in iron deficiency.
Animals↗
The effects of bradykinin, angiotensin and acetylcholine on the bovine adrenal medulla.
1. The response of the adrenal medulla to the intra-arterial injection of angiotensin, bradykinin and acetylcholine and to splanchnic nerve stimulation has been investigated in day-old and 3- to 18-month-old calves and in adult cats.2. Bradykinin and angiotensin had no appreciable effect on catecholamine release in the day-old calf nor did these peptides potentiate the response of the gland to acetylcholine.3. In older calves the response of the gland to bradykinin and angiotensin was marginally above the control output, whereas acetylcholine and splanchnic nerve stimulation caused a 10-100 fold increase in the rate of secretion. The response to acetylcholine but not to the peptides was related to the dose administered.4. The adrenal medulla of the cat was stimulated by angiotensin and bradykinin but the maximum amounts released by the peptides were much smaller than the discharge elicited either by splanchnic nerve stimulation or by acetylcholine. No dose-response relationship could be found for either adrenaline or noradrenaline released by angiotensin, or for noradrenaline released by bradykinin. The slight increase in adrenaline output which followed the injection of bradykinin was dependent on the dose but the slope of the curve (b = 0.161) was much less than that for acetylcholine (b = 0.636).
Acetylcholine↗