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Biomedical subjects

D G Uzbekova

Publications and source records attributed to D G Uzbekova.

15 recordsLinked to original sources
PubMedDate not supplied

[The antioxidant properties of parmidine in a toxic lesion of the liver].

The experiments on rats with toxic lesions of the liver induced by tetrachlorinemethane showed that parmidine (pyridinolcarbamat) promotes the reduction of the activity of lipid peroxidation in the liver tissue homogenates and erythrocytes. The pronounced tendency towards normalization of free-radical oxidation correlated with the positive dynamics of the histological picture of the liver.

Animals↗
PubMedDate not supplied

[On the 125th anniversary of the birth of academician N. P. Kravkov].

The article deals with the description of the life and activities of the founder of the Soviet pharmacology Academician N. P. Kravkov. Based on the great documentary material the author traces the way of the formation of N. P. Kravkov as a person and as a scientist. Some little-known facts of the scientist's biography are covered.

History, 19th Century↗
PubMedDate not supplied

[The effect of parmidine on the lipid peroxidation processes in coronary atherosclerosis].

During the formation and development of atherosclerosis the intensity of lipid peroxidation and the activity of antioxidant defence system significantly change. The use of parmidine decreases the contents of primary and secondary products of lipid peroxidation, reduces peroxide hemolysis of erythrocytes and increases the content of reduced glutathione in erythrocytes of patients with atherosclerosis. This shows that parmidine possessing the antioxidant properties stabilizes lipid peroxidation processes and normalizes the physiological antioxidant system.

Coronary Artery Disease↗
PubMedDate not supplied

[The effect of testosterone propionate on energy metabolism indices and the catecholamine content of the vascular wall].

The effect of testosterone propionate (1 mg/kg) on the specific activity of lactate dehydrogenase, malate dehydrogenase, contents of pyruvic and lactic acids, levels of catecholamines in target tissues and non-target tissues of rats was studied. Deficit of androgens and their single compensation by administering testosterone propionate lead to an inhibition of energy formation, a decrease of enzyme activity and contents of metabolites in tissues of the seminal vesicles. The course administration of testosterone propionate increases the activity of malate dehydrogenase in the aorta and myocardium. Acetylsalicylic acid (40 mg/kg) induces an increase of noradrenaline levels in the heart and aorta along with an increase of androgen level in the organism.

Animals↗
PubMedDate not supplied

[Aminazine distribution in the organs and tissues of rats depending on the routes of administration and the age of the animals].

Distribution of intramuscular and oral aminazin (20 mg/kg) in the brain, lungs, liver, kidneys, heart, ileum, blood and urine was studied in young and old male rats. Intramuscular drug showed maximal accumulation in the lungs and intestine, respectively, whereas at oral administration maximal and minimal accumulation was recorded in the liver and kidneys. Urine excretion of parenteral aminazin was 4-7-fold higher as compared to oral administration. Delayed accumulation of aminazin in the organs and its decreased excretion with urine were recorded in old animals.

Aging↗