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Biomedical subjects

D Garnier

Publications and source records attributed to D Garnier.

At least 73 records · Page 4Linked to original sources
PubMed1981

[Transfer of CO after prolonged artificial ventilation (18 young people after their stay in the neuro-surgery department) (author's transl)].

We studied the transfer of CO (TLCO) on 18 young people after their stay in the neuro-surgery department, during which they had been submitted to prolonged artificial ventilation. The values of TLCO measured after the single breath method and that of the steady state are all reduced. No statistical correlation has been brought to light between the length of artificial ventilation, or the FiO2 and the lowering of TLCO, or between the seriousness of the pulmonary complications which occurred and the disturbance of the pulmonary function test. To explain the change of the alveolo-capillary diffusion, different factors can be brought in, such as: artificial ventilation, the toxicity of oxygen, the adult respiratory distress syndrome, but also the presence of brain lesions which by reflex artery, modify the local hemodynamic conditions and the surfactant synthesis.

Adolescent↗
PubMed1978

The action of acetylcholine on background conductance in frog atrial trabeculae.

The action of acetylcholine (ACh) on membrane potential and currents in frog atrial muscle has been studied with a double sucrose gap technique. The results show the following. 1. ACh induces the development of an extra current, outward at the resting potential, which is dependent on the ACh concentration. 2. The preparation does not show any sign of desensitization. 3. The reversal potential of the current induced by ACh is between 0 and 20 mV more negative than the resting potential and behaves as a K electrode. 4. The mechanism of ACh-induced K conductance presents inward going rectification properties. 5. The delayed outward current is not affected by ACh. However the evolution of its tail current seems to indicate a process of K accumulation related to the ACh-induced current.

Acetylcholine↗
PubMed1978

Correlations between variations of electrical field at the body surface and contractions of the stomach in guinea pig.

1. The slow potentiel changes of the base line of the electrocardiogram recorded by cutaneous electrodes, here called EGEG (electrogastroenterogram) have been recorded simultaneously with the electromyogram and pressure variations of the stomach antrum. 2. Periodic fluctuations of EGEG, 400 microV amplitude, were correlated with activities of the antrum EMG consisting of 3 to 6 mV spikes superimposed on slow wave of depolarization, and with gastric intraluminal pressure of 5 to 7 cm of water. 3. An anticholinergic drug abolished all those activities. A gastric contracture flattened the EGEG. 4. Rhythmic distensions of the antrum induced a synchronous modulation of EGEG, the magnitude of which was correlated with the amplitude of distension. These result suggest that the origin of EGEG is essentially the movements of stomach.

Animals↗
PubMed1976

[Electrophysiologic study of the cholinergic receptor of the myocardial membrane].

A double sucrose gap voltage clamp technic has been used to study the extra-current induced by acetylcholine (Iach) on the myocardial membrane on frog atrial trabeculae. I) No desensitization of the Iach current is noted for repeated perfusions of Ach. II) The Iach current is suppressed by atropine. III) The reversal potential Each is more negative than the resting potential --20 mV less than or equal to Each less than or equal to OmV.IV) The relationship Iach/Holding potential for various [K+]o shows a) That Each behaved as a potassium electrode, b) an inward going rectification. These results indicate that the cholinergic receptor might be related with the gk1 channel.

Acetylcholine↗