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Biomedical subjects

D Geddes

Publications and source records attributed to D Geddes.

54 records · Page 3Linked to original sources
PubMed1984

Extrinsic allergic bronchiolitis in a bird fancier.

A patient in whom a severe systemic illness was characterised by weight loss, arthralgia and breathlessness was exposed to her pet bird. This pragmatic approach reproduced the features of her illness. The changes that occurred in her pulmonary physiology and histology differed from those seen in extrinsic allergic alveolitis in many important respects.

Adult↗
PubMed1981

Computerized axial tomography in the pretreatment assessment of small-cell carcinoma of the bronchus.

Computerized axial tomographic scans (CAT scans) of thorax and abdomen were used as part of the initial staging procedure of 50 consecutive patients with small-cell bronchogenic carcinoma (SCBC). The aims were to define the extent of the primary tumor and metastatic spread, and to compare the information obtained from CAT scans with conventional staging procedures. With CAT scanning, spread of the primary tumor was found to be far more extensive than originally believed when defined by conventional assessment. Of 35 patients conventionally staged as localized T1 or T2 tumors, 27 (77%) had their stage increased to extensive T3 disease. similarly, subcarinal lymph nodes were found in one patient when conventional methods were used (2%), but 16 patients (32%) were found when CAT scan was used. Unsuspected adrenal metastases were found in eight patients (16%) and retrocrural nodes in four patients (8%). Thirty-seven patients (74%) were found to have Stage III tumors when conventional staging was used; 47 patients (94%) were found to be Stage III following CAT scanning, demonstrating that, within the thorax, localized tumors are very uncommon. CAT scanning demonstrates the degree of intrathoracic spread very clearly, and has a valuable role in the initial investigation of patients with SCBC if the planned treatment includes radiotherapy.

Adrenal Gland Neoplasms↗
PubMed1980

Central and peripheral actions of amphetamine on memory storage.

These experiments investigated the effects of central (intracerebroventricular) and peripheral (i.p.) posttraining administration of D-amphetamine on rat's retention of a one-trial inhibitory avoidance response. While retention was enhanced by i.p. administration (1.0 mg/kg) the central administration (dose range 50-500 microgram) did not affect retention. In rats given peripheral 6-OHDA 24 h prior to training a lower dose (i.p.) of amphetamine (0.25 mg/kg) was most effective in enhancing retention. These findings suggest that the mrmory enhancing effects of D-amphetamine are mediated at least in part through peripheral systems.

Animals↗
PubMed1978

Motor development profiles of preschool deaf and hard-of-hearing children.

11 deaf and hard-of-hearing preschool children generally exhibited normal or at-age profiles of motor development. The few delays in certain functional areas were assumed to be due partially to lack of training and play experience rather than to deafness or hearing impairment. Two boys had a variety of motor and physical problems. Also some of the at-age children functioned above-age in a few skill areas. Two of the 4 children who demonstrated specific balance skill deficits had had meningitis at an early age; this supported the rationale that there was a relationship between etiology of meningitis and specific balance difficulties.

Child Development↗
PubMed1977

Assessment of the agglutination test for tuberculosis.

A new whole cell agglutination test for active tuberculosis, for which encouraging results have recently been reported, has been carried out on the serum of 112 subjects. The results have been disappointing; the test had no predictive value in the diagnosis of active tuberculosis.

Agglutination Tests↗
PubMed1977

Motor development of autistic monozygotic twins: a case study.

A pair of autistic monozygotic twins were assessed on relevant portions of the Geddes Psychomotor Inventory. Over-all motor development of the 3-yr., 6-mo. old twins was similar and considered a partial consequence of the same genotype and comparable environmental experiences from birth. The twins exhibited poor or unsuccessful performance on tasks requiring abilities in language, communication, and appropriate relationships to objects; superior performance on specific fine manual motor skills, walking balance board, and climbing; at-age performance on tasks which were considered measures of patterned gross movement, balance, postural maintenance, and spatial orientation; and few typical autistic motor characteristics.

Autistic Disorder↗
PubMedDate not supplied

Cystic fibrosis: basic chemical and cellular mechanisms.

Cystic fibrosis (CF) primarily affects epithelial-lined organs, the most important being the lungs. Much of the known pathogenesis of the disease has been elucidated by the identification of the gene mutated in CF which encodes the cystic fibrosis transmembrane conductance regulator, a chloride channel in the apical membrane of epithelial cells of the respiratory and intestinal tracts.

Chloride Channels↗