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Biomedical subjects

D Gholam

Publications and source records attributed to D Gholam.

7 recordsLinked to original sources
PubMed2003

Primary breast lymphoma.

Primary breast lymphoma (PBL) is a rare form of localized extranodal lymphoma. Few reports are available in the literature concerning its treatment and outcome. Of the 34 cases of PBL seen at our institution over a 25-year period, 20 consecutive cases were treated with CHOP or CHOP-like chemotherapy regimen and had adequate biopsy specimens for histological review. All these 20 PBL were of B-cell origin including one case of Burkitt lymphoma, and 2 cases of low-grade histologic type. Sixteen of the 20 patients achieved a complete remission (CR) and 2 achieved a partial remission (PR) (>75% tumor regression). Two patients had progressive disease while on therapy. With a median follow-up period of 80 months, 6 patients relapsed. Median time to relapse from diagnosis was 23 months (range, 3-41 months). Two of the relapses involved the central nervous system (CNS): isolated CNS relapse in one case and associated with other relapse sites in 1 case. The two patients who achieved a PR after chemotherapy also had disease progression to the CNS, 4 and 8 months after the end of CHOP chemotherapy. All 4 patients died of their disease 3, 6, 10 and 13 months after CNS involvement. Of the 16 centroblastic diffuse large B-cell lymphoma (DLCL), 3 had CNS disease at relapse. Three (15%) of our study patients developed a controlateral breast relapse. Twelve of the initial 20 patients were alive, including 11 with a persistent CR, 6 patients died of their lymphoma and 2 of unrelated diseases. In conclusion, we observed a high incidence of CNS relapse in this group of localized extranodal lymphoma, strongly suggesting that CNS prophylaxis should be associated with systemic chemotherapy in localized PLB.

Adult↗
PubMed1992

[Frontal stage in cervicofacial lift: the "helmet crest" technique associated with rapid expansion].

The frontal level is generally the less and the last concerned in facial ageing and the classical incisions of the cervicofacial facelift provide no changes in the frontal and glabellar wrinkles. To avoid such residual defects, the authors perform for the lost ten years an important push back of a central band of the vertex (the so called "Helmet crest") by means of a bilateral triangular excision subsequently closed by VY. This push back needs a very large undermining in the subgalea plan, from the eyebrow and glabellar region to the crest of the hemet itself. The VY closure is now really facilitated by a rapid expansion obtained by a special T shaped expander which allows not only cutaneous expansion but also aponeurotic expansion of the reputedly inextensible galea. This technique avoids the coronal incision and its serious sequelae and may be carried technique out at the same time as cervicofacial face lift. It allows a personal, equilibrated tension of the facial mask which is the essential condition for a good presentation of natural expression of the face.

Female↗
PubMed1991

[Coronal approach of zygoma and direct osteosynthesis in post-traumatic dysmorphic sequelae].

A direct approach to the zygomatic arch can be a useful alternative for primary or secondary deformities in which simple well known technics are ineffective. This approach is very limited because of the anatomical elements located directly over the zygomatic region. The exposure of the fracture site is performed by an unusual surgical approach which allows visualization of both zygomatic arches simultaneously, to correct all deformities and to perform osteosynthesis. Four cases using this technique are reported and the value of this approach is assessed.

Adult↗
PubMed1991

[The gracilis muscle as musculocutaneous flap. Evaluation of 20 cases].

The use of gracilis as muscular or myocutaneous flap is very well-known. The authors report 20 cases of gracilis flap including 13 reconstructions of the vaginal cavity following extended abdomino-perineal resection. Some technical points concerning the localization of the cutaneous part of the flap and the pedicle dissection are discussed. The use of gracilis flap is still limited in surgical teams following extended abdomino-perineal resection, nevertheless it is a very useful flap because of its low morbidity, the shortening of patient hospitalization and the very satisfying aesthetic result of the neo-vaginal cavity.

Evaluation Studies as Topic↗
PubMed1989

[A permanent expanding prosthesis and the latest refinements in breast reconstructive surgery].

The use of an expanding prosthesis that can be left in place after adjustment of its volume allows an improvement in the quality of the results of breast reconstructive surgery. This implant offers many advantages: 1) It doesn't have to be changed: only the valve and the inflation tube must be removed. 2) The ideal breast volume can be progressively obtained by gradually prompting the skin. 3) A transient overinflation before returning to the desired volume often results in a more natural looking and preptotic breast. An adjuvant method (tattooing of the nipple-areola) is also presented. It contributes to the improvement of the aesthetic nature of this type of reconstructive surgery. The author's series consists of 26 reconstructions which demonstrate the interesting possibilities offered by this implant and by the adjuvant method applied to the nipple-areola.

Breast↗
PubMed1989

Kinetics of adriamycin injected proximal to a tumor: a comparative study between venous and arterial injections.

A kinetic study of plasma concentration of Doxorubicin (Adriamycin) was performed in 25 cases of malignant melanoma of the extremity with malignant adenopathy, treated with the same dose (20 mg per m2). Drug concentration was measured using a radioimmunoassay, with good intra-assay and inter-assay reproducibility. The kinetic analysis used the multiple compartmental method and a simulation of the plasma curves. Adriamycin injected intravenously quickly leaves the plasma into an exchangeable compartment with a slow plasma return and subsequent prolonged mean duration of the plasma half life at a low concentration. Thus, the intravenous perfusion results in a high plasma concentration only during the time of infusion. After intra arterial injection proximal to the tumor, a fraction variable (average 35%) is not released back into the circulation, or released very slowly. This local sequestration (important in terms of local concentration) explains the efficiency and the potential local toxicity of this method of administration. The rapid release of about 70% of the drug into the plasma, with kinetics similar to that observed after intravenous infusion, allows for no significant reduction of systemic toxicity.

Adult↗