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Biomedical subjects

D Gisser

Publications and source records attributed to D Gisser.

8 recordsLinked to original sources
PubMed1979

A simple method for incorporating single pass dialysate delivery and controlled ultrafiltration with the RP-6 high flux dialyzer.

A simple hemodialysis protocol has been developed to permit significant "middle molecule" clearance, yet retain normal low molecular weight clearance. The high flux RP-6 dialyzer has been combined with a single pass dialysate delivery system to provide accurate control of ultrafiltration without resorting to specialized or expensive equipment. By operating the RP-6 in the co-current mode, a simple valve on the dialysate output can be used to regulate ultrafiltration. At QB = 200 ml/min and QD = 500 ml/min, CU = 127 ml/min and CB12 = 56 ml/min at zero ultrafiltration rate; these values increase considerably with ultrafiltration. This protocol offers dialysis centers with standard equipment the opportunity to use high flux membranes in a routine manner.

Animals↗
PubMed1979

In vitro characterization of the RP-6 dialyzer: co-current and counter-current clearance as a function of ultrafiltration.

Analytical and graphical techniques are described for presenting clearance data as a function of ultrafiltration; thus for the first time comparison of clearance values between dialyzers can be made unambiguously. This simple method uses a hand calculator to determine three coefficients. Clearance has been shown to be accurately described by the equation C = alpha 1 + alpha 2 Qv + alpha 3 (1/QBi). This formula permits construction of easily read families of curves which can predict clearance values under most clinical situations. The RP-6 dialyzer is characterized by these methods for clearance of urea, glucose and vitamin B 12 for counter-current and co-current modes.

Blood Flow Velocity↗
PubMed1979

Standards for accurate in vitro characterization of dialyzers: test case the Vivacell.

A standard format is proposed for cataloging dialyzer transport data in order to improve communication and understanding of published results. The need for such a format is obvious from the ambiguity and lack of uniformity in published data. This report for in vitro characterization also describes an adequate experimental set-up for proper dialyzer characterization and an improved means for reporting uncertainty where curve fitting techniques are employed. The Vivacell dialyzer has been evaluated by these means as the first test case.

Blood↗
PubMed1978

Hyper/hypo-osmotic peritoneal dialysis.

This report concerns the augmentation of peritoneal dialysis using alternating hyper/hypoosmotic peritoneal dialysates, and covers a detailed examination of the longest lived, anephric goat to be maintained using this delivery system. Experimental results show that with this technique: 1) urea clearance can be increased some 200% over control values, 2) the convective transport of urea is unimportant and the increased urea clearance is due primarily to increased peritoneal permeability, 3) net ultrafiltration and electrolyte balance can be easily controlled by variation of total electrolyte and glucose about an appropriate mean. A detailed autopsy failed to demonstrate any gross or microscopic pathology.

Abdomen↗