PubMed Health⌕ Search

Biomedical subjects

D Godon

Publications and source records attributed to D Godon.

6 recordsLinked to original sources
PubMed1989

[Pesticides and cancer in a Quebec rural farming population: a geographical interpretation].

Data on the use of pesticides in agriculture and three types of cancer among the rural farm population were compiled for 34 drainage basins of the province of Québec for 1982 and 1983. The basins were divided following three categories of exposure (low, intermediate, high) on the basis of the level of pesticides sales. Results at the scale of the three categories show that among women living in rural farm areas, the relative risk (RR) for cancers of the lymphatic tissues is of 1.62 when highly exposed basins were compared to low exposed basins (95% Confidence Interval = 1.16; 2.25), and of 1.63 (95% CI = 1.08; 2.45) when they were compared to basins with intermediate exposure. For women of 35-64 age group, RR values are respectively of 3.15 (95% CI = 1.67; 5.93) in the first case, and 3.73 (95% CI = 1.54; 9.01) in the second case. By another way, at the level of the 34 drainage basins, correlation analysis have shown statistically significant positive associations between several variables representing pesticides utilization in agriculture and geographic variations of some cancers, according to sex and age groups, especially for the following: men, cancer of the brain (1-14 and 15-34 age groups), cancers of the lymphatic tissues (34-64) and leukaemia (1-14); for women, cancer of the brain (35-64), the lymphatic tissues (35-64, 65 and more, all ages) and leukaemia (15-34, 35-64, 65 and more and all ages). After that, principal components analysis has been performed using variables representing pesticides utilization and socio-economic status by basin. Height factors have been produced, including two socio-economic and six pesticides-factors. Factor scores have been introduced in multiple regression analysis to see the role of each factor in the explanation of spatial distribution of those cancers who had been identified in the correlation analysis before. Results have shown that in most of the cases, only pesticides-factors have significant relationship with those cancers. Socio-economic factors play a significant role only for the following cancers: men, lymphatic tissues, 65 years old and more; women, cancer of the brain all ages, leukaemia 1-14 and 65 years old and more. However, these results must be interpreted with caution for the goal of the study is to describe potential relationships.(ABSTRACT TRUNCATED AT 400 WORDS)

Adolescent↗
PubMed1989

Incidence of cancers of the brain, the lymphatic tissues, and of leukemia and the use of pesticides among Quebec's rural farm population, 1982-1983.

Massive use of pesticides in agriculture poses risks for the environment and for human health. Pesticides are toxic substances and the suggestion that some may be carcinogenic has been the source of much controversy. In this article we focus on the relation between the use of pesticides in agriculture and the incidence of cancers of the lymphatic tissues, the brain, and of leukemia in the rural farm population in 34 major drainage basins in the province of Quebec (Canada) for the period 1982-1983. The basins were grouped into three categories (low, intermediate and high exposure) based upon the amount of pesticide sold. The study of highly exposed basins shows an excessive incidence of leukemia (SMR = 1.69, p less than or equal to 0.05) for men in rural farm areas in the Yamaska river basin. This specific group's relative risk (RR) of incidence as compared to the urban male population is 2.27 (p less than or equal to 0.05). The RR is also high and statistically significant among the men in municipalities that draw their drinking water from wells (RR = 2.07, p less than or equal to 0.05) as compared to those where water is drawn from rivers. Most municipalities using wells are in the rural farm areas. These results suggest that there may be a relationship between leukemia and the use of pesticides in this drainage basin, and this hypothesis could be verified at the individual level in epidemiological studies.

Brain Neoplasms↗
PubMed1986

Cardiovascular mortality as it relates to the geographic distribution of employment in non-metropolitan Quebec.

This exploratory analysis examines relationships between employment-specific cardiovascular mortality and certain spatially-based potential risk factors. Standard mortality ratios (SMRs) are mapped on the basis of non-metropolitan primary and secondary employment basins of Quebec. In order to control for geographical anomalies, the data are broken down into three spatial grids: employment basins with the employment poles, employment basins without the employment poles and the employment poles (municipalities) taken alone. This cartography suggests a certain number of cardiovascular disease-prone employment areas in Quebec. Linkage analysis and principal components analysis are used to simplify and clarify the complex relationships that exist among selected independent variables (potential risk factors) and multiple regression analysis is used to identify the functional relationships between these employment, geographic and demographic variables and the study's dependent variable (ischaemic heart disease and cerebrovascular mortality) in the form of standard mortality ratios (SMRs). Cardiovascular mortality (SMRs) are found to be related negatively to an employment age-factor and, in the case of women, negatively to agricultural employment, marginally and positively to pulp and paper employment. It would appear that outside the very large cities in areas of primary and industrial employment, men are at greater risk of cardiovascular mortality during their working lives than those who are over the age of 65. Although it was not possible to establish strong positive links between most employment sectors and cardiovascular mortality, it is possible to conclude that there is a negative association for men between textile employment and cerebrovascular mortality; that in the case of women, those who work in agriculture are less at risk than women who are working in industrial employment. There is also some statistical evidence that there is an association between women in the pulp and paper industry and cardiovascular risk levels. This research provides some clues as to the need to investigate certain areas of employment that may be creating unnecessary risks to health, especially in the case of female workers.

Adult↗
PubMed1984

[Not Available].

Explore the source record for details and available documents.

Canada↗
PubMedDate not supplied

[Mortality due to cancers of the brain and lymphatic tissues and leukemia as a function of agriculture pesticide use in Quebec (1976-1985)].

Potential hazards associated with the use of agricultural pesticides are a growing concern for society. We describe the relationships between the mortality data for cancers of the brain, the lymphatic tissues and leukemia, and the spatial distribution of agricultural pesticide use for 34 drainage basins in Quebec, from 1976-1985. The basins were grouped into three categories (low, intermediate, and high exposure) according to the level of sales of pesticides. For cancers of the lymphatic tissues among women 35 to 64 years of age, a high relative risk (RR) was observed (RR = 1.91, 95% Confidence Interval = 1.14, 3.18) in basins highly exposed to pesticides compared to those with low exposure. Analysis of correlation for this cancer at 34 basins showed significant associations between geographical distributions of the Standardized Mortality Ratio (SMR) and those of numerous variables indicative of pesticide use in agriculture. Agreement between the results for mortality data in this exploratory study and the results from another study on cancer incidence data for 1982-1983, supports the hypothesis of a potential relationship between the use of pesticides in agriculture and cancer of the lymphatic tissues.

Adult↗