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Biomedical subjects

D Golan

Publications and source records attributed to D Golan.

35 records · Page 2Linked to original sources
PubMed1985

Blood level of C3 complement component as an aid in the management of acute phase glomerulonephritis.

Ninety-five patients with acute glomerulonephritis, based upon clearly defined pathological criteria, were studied and scored. The scoring was correlated to their levels of blood complement components. Patients with low C3 serum levels had a severe course during the acute phase of their disease, as compared with those with normal C3 serum levels. No such correlation was established with regard to C4 serum levels. It is suggested that C3 serum level may serve as an indicator of the expected severity of the inflammatory process and thus as an aid in the management of patients with acute glomerulonephritis in the initial phase of the disease.

Acute Disease↗
PubMed1984

Autoantibodies to epithelial cells (intercellular substance) and their correlation with clinical activity of pemphigus vulgaris.

The presence of autoantibodies to intercellular substance of squamous epithelium was studied in the sera of 46 patients suffering from pemphigus vulgaris. This study suggests that in the majority of patients suffering from the severe form of the disease the autoantibody titer can be used as a guide to prednisone therapy. However, in patients with a mild or moderate form, no such correlation is established.

Adult↗
PubMedDate not supplied

Prolactin response to electroconvulsive shock in anesthetized rats.

Serum prolactin level (SPL) of anesthetized rats was measured in response to electroconvulsive shock (ECS). This measurement served as an indicator of dopaminergic and serotonergic activity. Such neurotransmitter activity was modulated by pretreatment with cyproheptadine, parachlorophenylalanine (PCPA), pimozide, bromocriptine or L-dopa. A statistically significant lowered SPL was found in rats given ECS plus antiserotonergic agents, in comparison with animals receiving antiserotonergic agent or ECS alone. When ECS was administered to rats pretreated with the dopaminergic blocker, pimozide, there was a significant decrease in SPL, compared with animals receiving pimozide alone. When the dopaminergic system was stimulated by dopamine agonists, there was no elevation of SPL in response to ECS. Thus, there may be a balance between serotonergic and dopaminergic systems. The agents used in the experiment may upset this balance and produce a change in prolactin response to a given ECT stimulus.

Animals↗
PubMedDate not supplied

Postpartum maternal group B streptococcal meningitis.

Maternal group B streptococcal (GBS) meningitis is rare, with only four cases previously reported in the literature. In this review a fifth case of postpartum GBS meningitis is presented. The five cases are compared with 34 cases of GBS meningitis in nonparturient adults. All cases of maternal GBS meningitis followed a vaginal delivery. The mean age of patients who had GBS meningitis outside the perinatal setting was 55 years, and most of these individuals had associated illnesses or frank immunosuppression; the mortality rate in this group was 23%. In contrast, all five patients with maternal GBS meningitis recovered. The case presented herein, like the four previous cases, illustrates the point that when patients with maternal GBS meningitis are treated immediately and have been healthy before the infection, the prognosis is good.

Adult↗