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Biomedical subjects

D Goodman

Publications and source records attributed to D Goodman.

At least 55 records · Page 3Linked to original sources
PubMed1990

Manual asymmetries in the reproduction of a 3-dimensional spatial location.

Two experiments examined differences in the reproduction of preselected arm positioning movements. In Experiment 1, subjects defined a position in right space with a right index finger, or a position in left space with the left index finger, and then attempted to reproduce the position with either the left or the right hand. Subjects were more accurate when vision was available and when the reproduction hand was the same as the criterion hand. Availability of vision reduced the same hand advantage. There were no accuracy differences between the left and right hands. Experiment 2 was designed to determine whether the left-left and right-right criterion and reproduction advantages evident in the no vision condition of the first experiment were accounted for by the two movements being made by the same hand or by being performed in the same space. The results demonstrated that accuracy depended primarily on whether movements were made with the same hand. No right/left hand advantage was observed. The absence of a right hand advantage in either experiment may be due to the spatial complexity of the task examined or to the relative absence of any temporal constraints.

Adult↗
PubMed1990

Simultaneous epiglottitis and parotitis: a case report.

A patient presenting to the emergency department with simultaneous parotitis and epiglottitis is described. She underwent emergency airway intervention within 3 hours of presentation. This is the first case of simultaneous parotitis and epiglotitis. Diagnostic symptoms are discussed.

Critical Care↗
PubMed1990

Dosimetric intercomparison in the British Institute of Radiology fractionation study of 3F/week versus 5F/week in radiotherapy of laryngo-pharynx cancer.

A dose intercomparison was carried out by the National Physical Laboratory between the seven radiotherapy centres which contributed the largest number of patients to the British Institute of Radiology fractionation study of three fractions per week versus five fractions per week in clinical cancer treatment. Six of the centres showed remarkable agreement within the acceptable limits of error of the measurements. In one centre there appeared to be a physical dose discrepancy of 2.8% which was materially less than could be detected clinically.

Humans↗
PubMed1990

Visual disabilities related to intraocular lens design.

Intraocular lens implantation after cataract extraction has become a common practice in the United States. However, unwanted optical images can correct an otherwise successful surgery into one that causes patient dissatisfaction. Refinements in manufacturing design and finishing have greatly improved the quality of present day intraocular lenses, but there is continued interest in simulating the optics of the human crystalline lens. We will discuss the optical requirements of intraocular lenses and how these are influenced by optic design and dimension, and spectral transmission characteristics.

Humans↗
PubMed1989

Genetic and molecular characterization of suppressors of SIR4 mutations in Saccharomyces cerevisiae.

In order to learn more about other proteins that may be involved in repression of HML and HMR in Saccharomyces cerevisiae, extragenic suppressor mutations were identified that could restore repression in cells defective in SIR4, a gene required for function of the silencer elements flanking HML and HMR. These suppressor mutations, which define at least three new genes, SAN1, SAN2 and SAN3, arose at the frequency expected for loss-of-function mutations following mutagenesis. All san mutations were recessive. Suppression by san1 was allele-nonspecific, since san1 could suppress two very different alleles of SIR4, and was locus-specific since san1 was unable to suppress a SIR3 mutation or a variety of mutations conferring auxotrophies. The SAN1 gene was cloned, sequenced, and used to construct a null allele. The null allele had the same phenotype as the EMS-induced mutations and exhibited no pleiotropies of its own. Thus, the SAN1 gene was not essential. SAN1-mediated suppression was neither due to compensatory mutations in interacting proteins, nor to translational missense suppression. SAN1 may act posttranslationally to control the stability or activity of the SIR4 protein.

Alleles↗
PubMed1989

Evaluation of CSF rhinorrhea by computerized tomography with metrizamide.

This study evaluates the ability of metrizamide computerized tomographic cisternography (MCTC) to delineate the site of leakage in patients with cerebrospinal fluid (CSF) rhinorrhea. From 1981 to 1986, thirteen patients were examined by MCTC to localize the site of CSF leakage. A total of 17 studies were performed. Thirteen scans (76%) identified the site of CSF leakage. Nine of these scans were confirmed surgically. The other four scans were performed on patients who refused surgery. Of the 15 scans in patients with active CSF leaks, 13 (87%) were positive. Of the two patients with inactive CSF leaks, neither was positive. One patient is presented in whom MCTC was both diagnostic and therapeutic. In conclusion, MCTC has a high success rate in localizing the site of active CSF leaks.

Adult↗
PubMed1989

Posterior chamber intraocular lens implantation in the absence of posterior capsular support.

Because of the high incidence and great variety of complications associated with anterior chamber intraocular lenses, we have developed a technique for the implantation of a posterior chamber intraocular lens in the absence of posterior capsular support. The posterior chamber IOL is placed in the ciliary sulcus by suturing the superior haptic to the iris and the inferior haptic to the sclera at the ciliary sulcus. We have used this technique successfully in both complicated extracapsular surgery and secondary intraocular lens implantation.

Follow-Up Studies↗
PubMed1988

Acute idiopathic blind spot enlargement. A big blind spot syndrome without optic disc edema.

We examined seven patients who had a syndrome of symptomatic monocular blind spot enlargement without optic disc edema. Two patients had previous blind spot enlargement that resolved over several months. The scotoma in each patients was absolute, measured 15 degrees to 20 degrees in diameter, had steep geographic margins, and extended to within 5 degrees to 10 degrees of fixation. Typically, patients had normal visual acuity, color vision, pupillary responses, and ophthalmoscopic findings. Photostress recovery, tested in two patients, was prolonged in the affected eye. Fluorescein angiography showed no abnormalities corresponding to the scotoma. Orbital computed tomographic scans in three patients and visual evoked responses in one patient were normal. Multifocal electroretinography, performed in two patients, showed loss of retinal waveforms in a large region surrounding the optic disc. Our findings suggest that retinal dysfunction produces this big blind spot syndrome, but we do not know its cause.

Acute Disease↗
PubMed1988

Autotransplantation of parathyroid tissue into sternocleidomastoid muscle.

Four cases of secondary hyperparathyroidism were treated by total parathyroidectomy with autotransplantation into the sternocleidomastoid muscle. These total parathyroidectomy patients are presented to demonstrate the reliability of parathyroid autotransplantation into the sternocleidomastoid muscle. Our technique is described in detail, and all procedures were successful. In one case, the patient was found, in retrospect, to have an adenoma in the transplanted parathyroid tissue. When the patient developed graft-dependent hypercalcemia, a portion of the graft was easily excised under local anesthesia and the patient became normocalcemic. Parathyroid tissue should be transplanted into the sternocleidomastoid muscle rather than other sites because of easy accessibility, one operative site, less graft ischemia, a low incidence of infection, and a high success rate due to excellent blood supply.

Adult↗
PubMed1988

Predictive value of clinical, laboratory, pathologic, and treatment variables in steroid/immunosuppressive resistant lupus nephritis.

Twenty-seven patients with lupus nephritis and nephrotic syndrome had persistent disease activity despite an adequate trial of corticosteroids and immunosuppressive drugs; 30% were Asians, compared with 7% of our overall SLE population. Two years later, seven had a very good outcome and seven a poor outcome. Thirty clinical, pathological, laboratory, and treatment variables were analyzed in a good versus poor responder subset comparison in an effort to determine which factors were associated with favorable outcome. Administration of pulse steroids (P = .069) and a low biopsy chronicity index (P = .048) were associated with the good responder subset. Serum creatinine, biopsy class, blood pressure, complement, and anti-DNA values at entry as well as the choice of immunosuppressive drug were not helpful in predicting outcome. All seven good responders were plasmapheresed (P = .026). Patients with refractory lupus nephritis who have a low biopsy chronicity index may benefit from the use of pulse steroids or plasmapheresis, and controlled studies are suggested.

Adult↗
PubMed1988

Effects of a televised smoking cessation intervention among low-income and minority smokers.

In November 1985, a television smoking cessation program was broadcast for 20 days on the noon and 9 p.m. news. Smokers in West Garfield Park, an inner-city impoverished area of Chicago, were randomly assigned either to a comprehensive intervention or to a no-intervention control condition. Although 100,000 self-help manuals had been distributed throughout Chicago, none of the controls in this low-income area had obtained a manual. The intervention consisted of providing the smokers a self-help manual, the televised broadcast, weekly support meetings, and supportive phone calls. At a 4-month follow-up, 20% of treatment participants were abstinent compared to 9% of controls. The results indicated that intensive supplementary opportunities enhanced participation by low-income smokers in a media smoking cessation program.

Adult↗
PubMed1988

Detection of cerebral lateralization of function using EEG alpha-contingent visual stimulation II.

The replicative reliability of durations of alpha-blocking following visual stimulation over different cortical sites was assessed with the method of alpha-contingent stimulation. Fourteen right-handed undergraduates were tested in a randomized factorial design. Words or geometric designs of equal luminance were presented by computer to randomly selected visual half-fields contingent on the occurrence of alpha at one of 4 placements (left and right occipital and left and right temporal). The control (mean/s) of alpha-blocking durations was significantly greater for contralateral visual half-field stimulation compared to ipsilateral visual half-field stimulation. This and other results were interpreted in terms of the concept of replicative reliability of retinal-cortical connections to occipital and temporal lobes and affirm the validity and sensitivity of the method.

Adolescent↗
PubMed1988

Posterior chamber intraocular lens implantation in the absence of posterior capsular support.

Because of the high incidence and great variety of complications associated with anterior chamber intraocular lenses, we have developed a technique for the implantation of a posterior chamber intraocular lens in the absence of posterior capsular support. The posterior chamber IOL is placed in the ciliary sulcus by suturing the superior haptic to the iris and the inferior haptic to the sclera at the ciliary sulcus. We have used this technique successfully in both complicated extracapsular surgery and secondary intraocular lens implantation.

Cataract Extraction↗
PubMed1986

A systematic approach to analysing sports performance.

A systematic approach to the analysis of sporting events is discussed. The basic tenet is that objective quantification of critical events is required for a complete analysis. This approach encompasses diverse areas of methodology and research, such as quantification, biomechanics and physiology. The theoretical underpinning are behavioural, in so far as athletes produce observable behaviour that can be quantified and ultimately changed. Several areas of analysis are linked together in a general framework and each one of these areas is dealt with in detail.

Biomechanical Phenomena↗