PubMed Health⌕ Search

Biomedical subjects

D Goodridge

Publications and source records attributed to D Goodridge.

24 records · Page 2Linked to original sources
PubMed1971

The growth and persistence of foot-and-mouth disease virus in the bovine mammary gland.

In animals exposed to foot-and-mouth disease virus by indirect contact, virus was recovered from the blood, milk, pharynx, vagina and rectum for variable periods of time before clinical disease was apparent. Virus instilled into the mammary gland multiplied rapidly and virus concentrations greater than 10(7) p.f.u./ml. were recorded within 8-32 hr., depending on the virus strain and dose inoculated. Virus multiplication was accompanied by clinical signs of mastitis but the classical signs of foot-and-mouth disease did not appear for 52-117 hr. Dissemination of virus from the mammary gland occurred within 4-24 hr. and in some animals samples taken from the pharynx, mouth, nose and vagina contained virus for periods up to 97 hr. before the appearance of vesicular lesions. Virus production in the udder declined with the appearance of virus neutralizing activity in the blood and the milk but persisted in some animals for periods of 3-7 weeks. The ability of foot-and-mouth disease virus to persist in mammary tissue was confirmed by the demonstration of virus multiplication in the udders of immune animals.

Animals↗
PubMedDate not supplied

A three-year evaluation of four commercial equine influenza vaccines in ponies maintained in isolation.

Ponies held in isolation for 40 months were vaccinated and revaccinated with four commercial equine influenza vaccines. Little or no HI antibody was detected after the first inoculation; second and subsequent annual revaccinations produced peak HI antibody titres between 7 and 14 days. Titres fell quickly between 14 and 28 days and less quickly thereafter. The decline of HI antibody appeared to be related more to the initial titre attained and to the period after vaccination than to the composition of the vaccine. The response to a first annual revaccination was superior to that produced by a second annual revaccination. Ether-treated antigens were required to identify primary and secondary responses to the equine-2-component of vaccines.

Animals↗
PubMedDate not supplied

Vulnerable in a safe place: institutional elder abuse.

Elder abuse in institutions is a slippery concept. Besides inherent difficulties in operationalizing definitions of elder abuse, it is well-recognized that under-reporting and methodological problems in research studies have created a knowledge base that is far from definitive. There is, however, much that can be gleaned from the literature and translated into clinical practice. Environmental factors, including both interpersonal and institutional dimensions, may contribute significantly to risk for elder abuse. A number of client characteristics such as physical impairment, social isolation, cognitive status, and aggression also appear to increase the potential for elder abuse. While professional caregivers have not yet been extensively studied in terms of their role in elder abuse, burnout, lack of training, excessive workload demands, and other stressors may be implicated as factors contributing to abusive behaviour.

Aged↗