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Biomedical subjects

D Gottschild

Publications and source records attributed to D Gottschild.

At least 37 records · Page 2Linked to original sources
PubMed1985

Myocardial bioptic findings in correlation with TL-201 imaging and hemodynamic parameters in patients with latent cardiomyopathies suspected of having myocarditis.

Sixty-eight patients (24 males, 44 females, mean age 37.2 years) belonging to NYHA classes I and II were investigated. All patients had a nondilated ventricle as well as hemodynamic criteria of "latent cardiomyopathy." In 78% of the patients, a high susceptibility to infection, frequent angina, or possible myocarditis were found. In 75.5%, the mean pulmonary artery pressure was abnormal. T1-201 scintigraphy revealed perfusion defects in 78%. Dyskinesia or hypokinesia were found in 52%. The left ventricular ejection fraction was normal in 74%. On biopsy, pathologic findings were detected in 60.9% of patients with a high frequency of hypertrophy and fibrosis (50%). In two patients, lymphocytic infiltrates were found. Immunohistologically, deposits of complement, IgG, IgM, and gammaglobulin, mainly in the sarcolemma, could be identified in 19.1% of cases. The myocardium was normal in 39.1%; insufficient material was found in 5.9% of patients. Morphologic, scintigraphic, and hemodynamic findings could not be correlated but the combination of two pathologic parameters permitted diagnosis. Biopsy was the most effective diagnostic method in myocarditis.

Adolescent↗
PubMed1985

[Thallium myocardial scintigraphy, hemodynamics and left ventricular wall kinetics in patients with suspected myocardial sarcoidosis].

The cardiological examination of 22 patients (pts) with suspected heart sarcoidosis (histologically established lung sarcoidosis, heart rhythm disturbances, cardiomegaly) has revealed thallium scan defects in 20 pts at rest and during exercise. In 19 pts we found pathologic left heart wall motions established by laevocardiography by applying the half axis method. The number of pathologic half axis shortenings correlated with ejection fraction, but not with left ventricular enddiastolic pressure and left ventricular enddiastolic volume index. IHD could not be found in coronarography in any case. Myocardial biopsy did not show myocarditis. Cardiomyopathies, other specific heart muscle diseases or rheumatic myocarditis could not be excluded as causes of the results mentioned above. The follow-up examinations of the patients will give more detailed information on the etiology of the pathologic cardiac findings.

Arrhythmias, Cardiac↗
PubMed1984

[Persistent infarct signs--obligate symptoms of heart wall aneurysm?].

Out of 19 cases the ECG of which on an average during 6.1 years demonstrated persisting signs of an infarction at stage I in 13 cases a comparison between clinical and ECG findings X-ray kymography and scintigraphy of the ventricle was possible. In 7 cases a congruence of the results was found. With regard to the differing findings on account of the clinical treatment, the ECG and the ejection fraction the greater diagnostic valency must be ascribed to the Tc-scintigraphy.

Adult↗
PubMed1982

[Differential hemodynamically oriented therapy in the early hospital phase of acute myocardial infarction].

100 patients with acute myocardial infarction were examined by means of catheterization of the pulmonary artery, dilution of isotopes and phonoelectrocardiography immediately after admission to the clinic and under a therapy following haemodynamic viewpoints within 2-24 hours after the beginning of the treatment, taking into consideration 15 parameters. According to a classification of the behaviour of the coronary circulation into normal function, hypovolaemia, hyperfunction, compensated insufficiency of the left heart, forward failure, retrofailure and cardiogenic shock the differential-therapeutic approach is described and the effects are explained. The haemodynamic examinations render possible the recognition of beginning circulatory complications still before their clinical manifestation, they result in founded therapeutic methods which are aimed at the correction of incorrect parameters which affect the O2-balance of the myocardium and thus the protection of the myocardium as well as the stability of the circulation, they allow a prognostic assessment of the course of the infarction and are suited to reduce the mortality of acute myocardial infarction in the early hospital phase by early recognition of developing pumping disturbances and their early treatment.

Adult↗
PubMed1981

[The hemodynamic profile of pentaerythrityl tetranitrate].

On altogether 17 patients with different stages of the chronic ischaemic heart disease before and after oral application of 20 and 40 mg PETN in form of Pentalong HR, AP, PAEDP and CO were measured. According to this PETN proves to be haemodynamically active, since in the optimum of the effect it reduces the PAEDP independent on the initial pressure by on an average 30-40%. The beginning of the effect lies between 30 and 45 min. The duration of the effect is prolonged, when 40 mg are used. A consequent nitrotherapy with PETN demands 4-6 times 40 mg, in these cases remains without any side-effects and is indicated in accumulated angina pectoris for smoothing the course of PAEDP, in angina pectoris with latent or manifest left heart insufficiency and in increase of the filling pressure after acute myocardial infarction.

Aged↗
PubMed1981

[Myocardial scintigraphy with Tc-99m-diphosphonate in patients with coronary heart disease: a comparison with ECG and hemodynamic examinations at rest and during exertion].

In 67 patients, 61 of whom underwent a myocardial infarction and 6 suffered from angina pectoris, myocardial scintigraphy was performed using the technetium-99m-diphosphate (Tc-99m-DP). In 51 patients the ECG and left pulmonary end-diastolic pressure (LPEDP) were investigated additionally at rest and during exercise (bicycle ergometre). A significantly higher occurrence of positive scintigrams was found in cases with marked coronary insufficiency, whereas with the normal ECG findings the negative scintigrams were significantly more often. Increased LPEDP values occurred more often with positive than with negative myocardial scintigrams, especially during exercise. The authors recommend the myocardial Tc-99m-DP scintigraphy for the assessment of the activity of pathologic process after acute myocardial infarction.

Angina Pectoris↗
PubMed1981

[Changes in circulatory parameters in dogs under general respiratory hypoxia].

The decrease in the oxygen content of the inspired air calls forth enhanced demands on the cardiocirculatory performance. In experiments on healthy dogs the haemodynamic shifts connected with short-term hypoxia were investigated, with particular attention to the possible presence of irreversible changes in the myocardium. With the aid of radiocardiography the following parameters were investigated before, during and after hypoxic test: blood volume, cardiac output, stroke volume, heart frequency, ejection fraction, mean right-to-left circulation time, and segmental lung volume. In dependence on the degree of hypoxia characteristic changes in the above parameters occurred. After the end of hypoxia most parameters returned to their initial levels. The presence of irreversible changes could not be proved. Under the given conditions, it was possible to test the individual level of cardiocirculatory performance with the aid of hypoxia similarly as by using the exercise test.

Animals↗