Biomedical subjects

D Grancai

Publications and source records attributed to D Grancai.

21 records · Page 2Linked to original sources

PubMed1999

[Determination of selected secondary metabolites and extracts of Philadelphus coronarius L].

The paper deals with the determination of selected secondary metabolites in the branches and leaves of Philadelphus coronarius L. Colorimetric methods were employed to determine the content of flavonoids (0.63% and 0.01%, respectively) and phenolic substances (3.25% and 0.70%, respectively) in leaves or branches. Also the content of extractive substances was determined in ethanolic, aqueous-ethanolic (85% and 60% ethanol), and aqueous extracts. This yielded 9.56%, 22.46%, 24.93%, and 33.15% of extractive substances in leaves and 2.20%, 6.04%, 8.84%, and 10.39% of extractive substances in branches.

Colorimetry↗

PubMed1998

Evaluation of potential carcinogenicity of steroidal alkaloids from Veratrum album L. by the DC polarography method.

The presented work is devoted to the study of polarographic reduction in the series of 13 alkaloids isolated from various parts of Veratrum album subsp. lobelianum. The used compounds were evaluated from the point of view of their potential carcinogenicity in anhydrous N,N-dimethylformamide (DMF) by the method of DC polarography. All compounds were reduced during an one two-electron irreversible step. Their potential carcinogenicity characterized by a parameter tg alpha value determined in the presence of alpha-lipoic acid ranged from the highest value 0.257 obtained for the solanidane skeleton containing rubijervine to the value 0.070 for jervine. The tg alpha value determined for rubijervine (0.257) is comparable with the tg alpha of naphto-(2',1',2,3)fluoranthene (0.270)-compound classified by IARC as possible carcinogen for human. The tg alpha values determined for other alkaloids were relatively low and they do not indicate any possible carcinogenic activity.

Alkaloids↗

PubMed1994

[Veratrum alkaloids. I].

Alkaloids represent an important group of therapeutically significant secondary metabolites. The plants of the genus Veratrum contain alkaloids with an antihypertensive effect. Also the genera Schoenocaulon and Zygadenus are sources of veratrum alkaloids. The present paper presents a survey of isolated alkaloids from the underground and aerial parts of 17 species of the genus Veratrum. The alkaloids occur as glycosides, aglycones or in the form of esters with various acids. In conformity with the IUPAC regulations for the nomenclature of steroids, Veratrum alkaloids were divided into 7 groups. The present paper lists the compounds of the first two groups, i.e. (1) alkaloids of the jervanine and veratranine types (I-XXIII), and (2) alkaloids with the cevanine skeleton (XXIV-XXXV). The individual compounds are characterized by their physico-chemical constants (melting point, optical rotation).

Veratrum Alkaloids↗