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Biomedical subjects

D Granoff

Publications and source records attributed to D Granoff.

8 recordsLinked to original sources
PubMed1999

Safety and immunogenicity of MF59-adjuvanted influenza vaccine in the elderly.

Safety and immunogenicity of the influenza vaccine adjuvanted with MF59 (FLUAD) were compared to those of a non adjuvanted subunit vaccine in elderly subjects during three consecutive influenza seasons. Geometric mean titres and proportions of subjects with either a > or = four-fold increase in antibody titres or with an HI titre > or = 128 after immunisation were higher in FLUAD recipients. The adjuvant effect on the magnitude of the responses was most pronounced in subjects with pre-vaccination titres < or = 40. Although associated with more frequent mild local reactions, the adjuvanted vaccine was well tolerated. Thus, the addition of MF59 increased the immunogenicity of the subunit influenza vaccine in elderly persons with low pre-vaccination titres, who are at greatest risk of developing severe influenza disease and vaccine failure, without a clinically important increase in reactogenicity.

Adjuvants, Immunologic↗
PubMed1991

Syndactylization for the treatment of fifth toe deformities.

The authors describe a procedure to syndactylize the fourth and fifth toes for the correction of failed fifth toe arthroplasty, flail fifth toe, overriding fifth toe, cocked-up fifth toe, heloma molle, and congenital digitus minimus varus. The procedure is technically simple and produces good cosmetic results.

Congenital Abnormalities↗
PubMed1985

Pharyngeal colonization with Haemophilus influenzae type b in children in a day care center without invasive disease.

During an 18-month period, monthly pharyngeal cultures for Haemophilus influenzae type b (Hib) were obtained from 66 children and their caretakers in a day care center in which no systemic disease caused by Hib occurred. The average colonization rate for Hib was 10%, and ranged from 0% to 23% for a single month. Infants housed in a separate building with a cohorted staff were not colonized by Hib. However, 71% of the toddler group and 48% of the preschool group became colonized by Hib at some time during the 18-month-study. Of 89 Hib isolates, 93% were biotype 1 (Kilian), and 90% of these had a similar outer membrane protein profile, designated subtype 1L. This strain was recovered from children at the center for 15 of 18 months. No invasive disease occurred. Thus, Hib may be widespread among preschool children in a day care center and persist for longer than a year without resulting in systemic disease.

Child↗
PubMed1984

Tonsillectomy--some like it hot.

Methods of tonsillectomy using electrocautery for dissection and hemostasis are gaining popularity. A prospective, controlled, randomized, single blind study was designed to compare this method to tonsillectomy performed by scissor dissection with suture hemostasis. In general, tonsillectomy by electrocoagulation was found to reduce operative time and blood loss, and to increase postoperative pain and prolong healing. Overall morbidity in the study was low, and no significant differences in complications, e.g., bleeding were noted.

Anesthesia, General↗
PubMed1982

Salmonella gastroenteritis in the first three months of life. A review of management and complications.

Salmonellosis in older children and adults is usually a self-limited disease, but the risk of complications in infants is not well-defined. We performed a retrospective review of 52 patients. 90 days of age or less, seen at the St. Louis Children's Hospital between 1975 and 1981 with stool cultures positive for salmonella. Sixteen were 30 days old or less (neonates), 21 were 31- 60 days of age, and 15 were 61-90 days old. Among patients in whom blood cultures were done initially, bacteremia was most frequent in neonates: 5/11 (45%), compared to 2/18 (11%) in older infants. All seven infants presenting with bacteremia received 10 or more days of antibiotic therapy: yet complications (osteomyelitis, fatal meningitis or chronic diarrhea) developed in three of five neonates and one of two older infants. Complications also developed in seven of 22 patients who initially had negative blood cultures, including two infants in whom sepsis later developed and two infants who required intravenous hyperalimentation because of chronic diarrhea and malnutrition. The group of 23 patients who did not have blood cultures all did well. Salmonellosis is not necessarily a self-limited infection in young infants. Even in the absence of bacteremia, clinicans would appear to be justified in using antimicrobial therapy in infants 3 months of age or les with salmonella gastroenteritis, particularly neonates of older infants with symptoms of dysentery or failure to thrive.

Age Factors↗
PubMedDate not supplied

Classifications of radiopaque lesions of the tendo Achillis.

The authors present an anatomically-based classification to identify radiopaque lesions of the tendo Achillis. Numerous etiologic and pathologic processes are responsible for the formation of radiopaque lesions found in this tendon. The anatomical location and morphologic appearance of the lesions are represented in this classification system to better acquaint the physician with reported etiologic causes. Treatment based upon classification sites are discussed to complete this historical presentation.

Achilles Tendon↗