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Biomedical subjects

D Grgicević

Publications and source records attributed to D Grgicević.

At least 19 recordsLinked to original sources
PubMed1994

Alloimmunizations following blood transfusions.

A retrospective study was performed to estimate the rate of alloimmunization against red blood cell (RBC) antigens in hospitalized patients and the frequency and specificity of clinically significant alloantibodies (CSA) detected during routine pretransfusion testing of 10,641 blood samples. Clinically significant alloantibodies were found in 116 out of the 10,641 tested serums (1.09%). The incidence of CSA in two surgical groups of patients was 0.18% and 0.68%, respectively. In patients with hematologic diseases the frequency of CSA was 17.6%, in patients with uremic disease it was 14%, and in patients with cirrhosis hepatis it was 6.9%. The incidence of clinically significant alloantibodies in patients who had one to five exposures to RBC antigens was 5.1%; in patients who had six to fifteen exposures, 87.9%; and in patients with more than fifteen exposures, 6.8%. The most frequently found single alloantibodies were anti-Kell (22%), and the following irregular alloantibodies were found with decreasing frequency: anti-E (20%), anti-D (11%), anti-c (10%), anti-C (7%), anti-Kidd (6%). The most frequent alloantibodies found together with other alloantibodies had anti-Duffy specificity (80%), and the following irregular alloantibodies were found with decreased frequency: anti-C (70%), anti-c (57%), and anti-Kidd (50%).

Female↗
PubMed1983

[The effect of long-term plasmapheresis on the composition of blood. III. Changes in the concentration of total, direct and indirect bilirubin, alkaline phosphatase, serum transaminases (SGOT, SGPT). total lipids, triglycerides and cholesterol].

In the group of blood donors submitted to the long term plasmapheresis with the weekly withdrawal of 370--670 ml of plasma, the concentrations of total bilirubin, alkaline phosphatase, aspartate (GOT) and alanine (GPT) transaminases, total lipids, triglycerides and cholesterol were not significantly changed (P greater than 0,05). The mean concentration of total lipids in plasma donors were close to the upper normal limit, while the concentrations of triglycerides slightly increased simultaneously with the increase of the number of plasmapheresis. The mean concentrations of indirect bilirubin significantly decreased (P less than 0,05) and the concentrations of indirect bilirubin increased (P less than 0,05), but because they do not differ significantly from the concentrations of the control group, these changes are of no clinical importance.

Alanine Transaminase↗
PubMed1981

[Effect of long-term plasmapheresis on blood composition. I. Changes in the concentration of total proteins, electrophoretic fractions and immunoglobulins].

Effects of long term plasmapheresis on blood constituents was examined in the plasma donors from whom 220-660 ml of plasma was withdrawn weakly. The donors were submitted 3-300 times to double plasmapheresis procedures. Small decreases in concentrations of total proteins, albumins, gamma-globulins, immunoglobulins IgA and IgM were observed as well as the increases in the concentrations of alpha-1-globulins (p less than 0,05), alpha-2-globulins (p less than 0,05), beta-globulins (p less than 0,05) and immunoglobulins IgG (p less than 0,05). The statistically significant changes were observed earlier in the course of plasmapheresis in donors submitted to more intensive regime.

Blood Proteins↗
PubMed1981

[Effect of long-term plasmapheresis on blood composition. II. Changes in the concentration of coagulation factors, inhibitors, thrombocytes and its effect on routine tests of coagulation].

The influence of serial, double plasmapheresis on blood coagulation was evaluated in two groups of plasma donors submitted from three up to 306 plasmapheretic sessions. An average of 375 or 660 ml of plasma respectively were weekly harvested from the donors. No statistically significant changes were observed in platelet count, activity of factor V and factor VIII, fibrinogen, plasminogen, alpha-2-macroglobulin, antithrombin III and prothrombin time, irrespectively of the frequency and the number of plasmapheresis. The concentration of alpha-1-antitrypsin was already increased after 7 plasmapheresis in both groups of donors. KCCT was progressively shortened with the increasing volume of harvested plasma (p 0.05) and thrombin time was prolonged (p 0.05).

Blood Coagulation Factors↗
PubMed1980

Observation of the changes of plasma proteins after long term plasmapheresis.

The influence of long term plasmapheresis on the health of donors was examined in two groups of plasma donors that donated mean volume of 411 ml of plasma during 176 weeks and 670 ml of plasma during 123 weeks (p less than 0,05). The control group consisted of 27 whole blood donors. Statistically no significant differences (p greater than 0,05) were found in the concentrations of total proteins, albumin, gammaglobulins, immunoglobulins, alpha 1 antitrypsin, alpha 2 macroglobulin, plasminogen, fibrinogen, factor V, factor VIII, GPT and alkaline phosphatase. Although the difference was significant for bilirubin and GOT the mean values were within the normal range. Significant elevations were found in alpha 1 globulins, and alpha 2 globulins in the group that donated 411 ml of plasma/week after 35 sessions. In this latter group of donors the elevation of beta globulins was observed after 100 sessions. On the basis of these results we suggest that plasma donors should not donate more than 500 ml of plasma per week and that the maximal number of regular plasmapheresis should not exceed 70. The yearly number of sessions should therefore not exceed 50 and the yearly donated volume of plasma should be not more than 25 liters.

Alpha-Globulins↗
PubMed1979

[Analysis of the use of blood and blood components at the Dr. O. Novosel Internal Medicine Clinic in Zagreb].

The use of blood and components was analysed during the period of two years in the Dept. of Med. "O. Novosel", Med. Fak. of Zagreb. The blood use factors were compared with those from other hospitals and hospital staff's transfusion practice was judged by them. The use of blood was higher than in the compared hospitals due to the extremly high use in the Dept. of Haematology. This department is highly specialised with predominancy of patients with haematologycal malignancies. The blood factors of other departaments compare well with these from other hospitals. Blood component therapy in an accepted principle and is fully practiced. 77% of all transfusons were given as PRC. Difficulity in management of haemotherapy is clearly seen by the fact that only 72% of reqested doses were supplied by Blood Transfusion Service. For each Rhesus positive received dose of blood it was neccessary to order 1,4 doses and for each A Rhesus negative dose, 2 doses. The worst situation was with B and AB Rhesus negative blood. For one received dose it was neccessary to order 2.9 and 2,8 doses respectively. Similar situation was with blood components. Only 64% of requested platelet concentrates and less than 42% of granulocyte concentrates were obtained. The shortage of blood and blood components is a serious hindrance to the optimal treatment of patients.

Blood Transfusion↗