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Biomedical subjects

D Grison

Publications and source records attributed to D Grison.

18 recordsLinked to original sources
PubMed1986

[Septal subaortic hypertrophy. Apropos of 23 cases].

Septal subaortic enlargement is seen by two-dimensional echography and involves localized hypertrophy of the basal part of the interventricular septum, the thickness of which is greater than or equal to 13 mm. The present study relates to 23 septal subaortic enlargements. Means thickness of the enlargement was 17.0 mm and the longitudinal parasternal length was 22.1 mm. SAM was noted in 2 cases and mesosytolic closure of the sigmoid sinuses in one case. Left ventricular volume was much reduced in one third of cases, especially when enlargement was great. Compliance disorders were marked in one third of cases. Only the longest and thickest enlargements caused obstruction, which was noted in 18% of cases. Enlargement was most often associated with valvular (56% of cases) or hypertensive (48 P of cases) pathologies. No specific clinical, radiologic or electrical signs were noted; anomalies were due to pathology associated with the enlargements. A stable trend was generally seen in subaortic hypertrophy after a mean period of 33 months. Nevertheless, moderate increases in hypertrophy were seen in 20% of cases. In the great majority of cases, enlargement did not correspond to obstructive hypertrophic cardiomyopathy according to Goodwin's criteria, and etiology remains uncertain due to lack of histological data.

Adult↗
PubMed1985

[Beta-blockers in the acute phase of myocardial infarction. Echographic study].

The purpose of this study was to evaluate the ability of beta blocker therapy in decreasing the amount of necrosis during a first transmural myocardial infarction (as evidenced by a local and overall kinetic study using two-dimensional ultrasonography). Twenty patients were randomly placed into 2 groups. Ten patients received 15 mg of metoprolol intravenously followed by 200 mg daily of the drug orally. The results indicated that beta blockers are well tolerated clinically and hemodynamically, and that they significantly reduced the amount of necrosis (p less than 0.05 in anterior myocardial infarctions).

Clinical Trials as Topic↗
PubMed1984

[Echography in the surveillance of myocardial infarction during the acute phase].

An attempt is made to determine feasibility and capabilities of two-dimensional echocardiography (2DE) during acute myocardial infarction (AMI). Seventy-four consecutive patients with AMI (22 anterior, 29 inferior, 4 lateral, 5 non-transmural) underwent 2DE; in sixty cases, suitable examination was available. Regional wall motion abnormalities were studied by 2 methods, i.e. qualitative in all patients and quantitative in 32 patients. Akinesis or dyskinesis occurred in 57 cases (21/22 in anterior, 4/4 in lateral, 29/29 in inferior, 3/5 in non-transmural AMI) and was observed very early (within the first 24 hours after onset of chest pain). Intraventricular clots were observed in 8 patients (in 7 patients during anterior or lateral AMI) without peripheral embolization. In conclusion, 2DE is a suitable method for evaluation of AMI, especially in early thrombi detection and qualitative wall motion analysis. Evolution of quantitative wall excursion is still under investigation but will be highly attractive, more easily repeatable at the bedside and cheaper than nuclear angiography.

Adult↗
PubMed1983

[Course and prognosis of primary hypertrophic cardiomyopathies].

33 patients with hypertrophic cardiomyopathy were followed for a mean duration of 48 months. 29 of them were reviewed; 6 had died, including 4 with a familial form belonging to two different families. No cases of sudden death were observed. The mortality rate was 4 p. cent at 1 year, 11 p. cent at two years and 21 p. cent at 5 years. The clinical course was marked by a functional deterioration in one-third of cases and, on echocardiography, by an increase in the diastolic diameter of the left ventricle and in the thickness of the septum, independent of the clinical course. Subjects from "high risk" families have a very poor prognosis (4 deaths out of 7 patients at an average age of 25). These families present major conductive disturbances on the electrocardiogram and a very marked parietal hypertrophy on the echocardiogram. No other prognosis factor independent of the familial aspect was revealed.

Adolescent↗
PubMed1982

[Coronary lesions in myocardial infarction].

The authors analyse the coronary lesions in 285 patients with primary myocardial infarction (164 anterior, 121 inferior infarcts) undergoing coronary angiography an average of 4 months after infarction. The statistical study of the analytical table of the lesions according to severity and site, demonstrated a significant difference in each group (p less than 0,001): --there was a very clear dominance of occlusion of the LAD artery in anterior infarction but severe narrowing (greater than or equal to 70%) was observed mainly on the right coronary and left circumflex arteries; --in inferior infarction, the incidence of occlusion was higher on the right coronary artery and severe narrowing was divided between the LAD and left circumflex arteries. Controlateral, double or triple vessel disease was present in 74% of anterior and 85% of inferior infarcts. There were many more patients with double and triple vessel lesions than with single vessel disease. Residual angina gave no indication of the extension of the lesions in anterior infarction but patients with this complication after inferior infarction had a higher rate of triple vessel disease. Stress testing is exploitable in inferior infarction but did not give any discriminating results. In this series, angina and stress testing only allowed triple vessel disease to be suspected in patients with inferior infarction. A coronary arteriographic study, by showing the severity and controlateral extension of the lesions, comparable in primary anterior and inferior infarction, gives important prognostic information and allows assessment of surgical possibilities.

Angina Pectoris↗
PubMed1981

[Echocardiography of an operated case of a myxoma of the tricuspid valve].

The case of a 6 year old child with a tricuspid valve myxoma is presented. Early diagnosis by echocardiography, confirmed by angiography, resulted in surgical cure before any symptoms appeared. This is the only reported echocardiographic study of a myxoma inserted on the tricuspid valve found in a review of the literature of 6 cases of right ventricular myxoma. The tricuspid valves were found to be thickened and prolapsed into the right atrium. The amplitude of excursion of the anterior leaflet was greatly increased, its mass projecting into the right ventricular outflow tract in diastole and remaining there until the end of right ventricular ejection. The echocardiographic signs localising the precise origin of the tumor in the tricuspid valve are developed. The differential diagnosis with right atrial myxoma prolapsing into the ventricular cavity, benign and malignant right ventricular tumours and tricuspid valve vegetations is discussed. The precision of the diagnostic information obtained by echocardiography suggests that angiography may not be essential any longer, especially when the risk of embolisation and acute obstruction are taken into consideration.

Child↗
PubMed1979

[Familial cardiomyopathy: a study of two families with myocardial and skeletal muscle biopsies].

Cardiomyopathy was diagnosed in several members of two families. This familial cardiomyopathy showed symmetrical or asymmetrical hypertrophy of the ventricular walls with or without obstruction to the left ventricular outflow tract. Certain forms were asymptomatic and were revealed by the family history and echocardiography. Myocardial and intercostal muscle biopsy was performed for a biochemical and ultrastructural analysis. Different myocardial features were observed in the two families: a large increase in the glycogen deposits in the one, without clinical signs of a glycogen storage disease, and intracellular deposits of a filamentous protein substance in the other.

Cardiomyopathies↗
PubMed1979

[Two-dimensional echocardiography of ventricular aneurysm. Study of 38 cases with angiographic correlation].

This is a study of the data supplied by cross-sectional echocardiography in the diagnosis of post-infarction aneurysm. It involves 38 confirmed cases of myocardial infarction. The clinical, electrical, radiological and echocardiographic data (in M mode) were specified. Right anterior oblique ventriculography showed 21 posterior and 17 anterior aneurysms (4 antero-lateral, 5 apical, 8 antero-apical), and 14 mitral regurgitations. Cross-sectional echocardiography using a (30 degrees or 90 degrees) mechanical sector scanner allowed the study of the kinetics of 6 segments following 5 viewing angles: one longitudinal, two transversal, two apical. Each segment was classified according to its shape and motion: akinetic, dyskinetic or aneurysmal, and the papillary muscles of the mitral valve were assessed as normal or pathological (dense and motionless on the echogram). 35 of the 38 aneurysms seen at angiography, were detected by cross-sectional echocardiography; in one case the diagnosis could not be made for technical reasons; in two cases echocardiography was in favour of akinesia. An abnormal papillary muscle was observed in the 14 cases of mitral insufficiency. The causes of error in localisation were considered. In conclusion, cross-sectional echocardiography appears to be an excellent atraumatic procedure for the diagnosis of aneurysms and papillary muscle dysfunction.

Adult↗
PubMedDate not supplied

[Course and prognosis of primary hypertrophic cardiomyopathies].

33 patients with hypertrophic cardiomyopathy were followed for a mean duration of 48 months. 29 of them were reviewed; 6 had died, including 4 with a familial form belonging to two different families. No cases of sudden death were observed. The mortality rate was 4 p. cent at 1 year, 11 p. cent at two years and 21 p. cent at 5 years. The clinical course was marked by a functional deterioration in one-third of cases and, one echocardiography, by an increase in the diastolic diameter of the left ventricle and in the thickness of the septum, independent of the clinical course. Subjects from "high risk" families have a very poor prognosis (4 deaths out of 7 patients at an average age of 25). These families present major conductive disturbances on the electrocardiogram and a very marked parietal hypertrophy on the echocardiogram. No other prognosis factor independent of the familial aspect was revealed.

Adolescent↗