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Biomedical subjects

D Grossklaus

Publications and source records attributed to D Grossklaus.

At least 19 recordsLinked to original sources
PubMed1995

Influence of local treatment on the recurrence rate of ductal carcinoma in situ.

BACKGROUND: Screening mammography has resulted in a significant increase in the diagnosis of ductal carcinoma in situ (DCIS). The role of breast conservation therapy and the long-term recurrence rate are still controversial. This article compares mastectomy, wide excision alone, and wide excision with radiation as treatments for DCIS. STUDY DESIGN: One hundred twenty-four cases of DCIS were retrospectively reviewed and were found to be pure DCIS by a senior pathologist. The mean age at diagnosis was 60 years (range, 33 to 81). Originally, 101 patients (81 percent) presented with calcification on mammogram, and 23 (19 percent) presented with a palpable mass. Histologic data showed that 54 (44 percent) had noncomedo type lesions, 46 (37 percent) had comedo type, and 24 (19 percent) had unknown type DCIS. RESULTS: Four of the 124 patients had a recurrence during a mean follow-up period of 43 months. Recurrence is defined as any development of DCIS or invasive carcinoma in the ipsilateral breast. There was one (1.3 percent) recurrence in the 75 patients treated with mastectomy (an adenocarcinoma of the chest wall), which occurred at 59 months. Treatment was 5,750 cGy to the chest wall and the patient is free of disease 37 months postradiation. There were three (11 percent) recurrences at 14, 21, and 29 months, respectively, in the 28 patients treated with wide excision alone. All three recurrences were found by calcifications on mammogram and all patients had comedo type original lesions. Two recurrences were pure DCIS of the breast. Both patients were treated with mastectomy and are free of disease at 33 and five months, respectively. The third recurrence was an invasive colloid carcinoma of the breast. Treatment was a modified radical mastectomy; the patient is free of disease after 62 months. There were no recurrences in the 21 patients who were treated with wide excision and radiation. Average total dose of radiation was 5,835 cGy (range, 4,500 to 6,480). CONCLUSIONS: The results of this study indicate that both mastectomy and wide excision with radiation are associated with very low recurrence rates. Wide excision alone is associated with a higher recurrence rate. However, all recurrences were detected mammographically and all lesions were salvaged by mastectomy. Therefore, the ultimate local control and survival rates were similar for all three modalities.

Adult↗
PubMed1994

[Animal health, food quality and consumer protection as a unit--introduction to a topic].

As a consequence of widely spread latent infections, animal health and the necessary examination of livestock have become an indispensable level of quality assurance. While so far, legislation in epizootics did not provide for a control of latent infections with an inapparent clinical course, the EC Directive on Zoonoses which has come into force in 1993 requires such an approach for the first time. As a consequence of the further increase in the number of cases of acute gastroenteritis caused by bacteria of the genus Salmonella, veterinary medicine and agriculture have been compelled to join forces and institute control measures aimed at rendering stocks most of which are maintained under conditions of intensive keeping free from defined agents of zoonotic diseases. This approached requires four levels of action, i. e. a suitable diagnosis, a creation of healthy stocks, the use of suitable immunoprophylactic methods and a safeguarding of the hygienic status achieved. With the aid of methods of genetic engineering, several research groups try to create the necessary conditions for doing so. They take account of the established knowledge that the necessary consumer protection cannot be afforded any longer because the performance of ante-mortem and post-mortem examination of meat animals is a limited one, unless three limits of quality assurance are adopted, i. e. examination at the farm of origin, ante-mortem and post-mortem examination of meat animals and control of food establishments and foods.

Animals↗
PubMed1993

[Salmonellae and consumer health protection].

To a major extent, the dramatic increase of food-transmitted infections caused by Salmonella is due to latent Salmonella infections in animal stocks. At the moment, a uniform clone of the phage type 4 of Salmonella enteritidis is mainly responsible. It causes illness through eggs or egg-containing food. Control of salmonellosis is made more difficult by the fact that, apart from affecting animal stocks, it has now contaminated the environment including feed stuffs. In addition, secondary contamination, occurring during both food production and processing, is a constant threat to public health. The most important aim must be the creation of Salmonella-free animal stocks by carrying out regular hygiene control and vaccination programmes and implementing immune-prophylactic measures. Because of the EC Zoonoses Guideline, redevelopment efforts will have to concentrate in the first place on poultry stocks. It is expected from the EC Egg Regulation, in force since May 1993, that it will drastically diminish the risk of infection from the final product. This paper discusses the most recent registration statistics and inspection results regarding food, animal stocks, faeces, sewage, feedstuff and soil samples. Furthermore, epidemiological facts as well as ways and causes of infection are described. Finally, the author gives recommendations for the fight against salmonellosis.

Animal Feed↗
PubMed1991

Notes on technical progress in veterinary public health.

Scientific and technical progress in the field of veterinary public health (VPH) over the last one hundred years has contributed to the protection of consumer health and the environment. This report presents examples of the success achieved in the control of epizootics of tuberculosis, brucellosis, rabies and trichinellosis, which are also zoonotic diseases. The discussion also considers hygiene measures in relation to Listeria in food as well as certain challenges resulting from the spread of latent infections among farm animals. The increasing incidence of Salmonella infections among humans is also considered. Other important VPH tasks include the control of chemical residues of varying origin and of toxic biological substances in foods. Examples are also presented of measures taken and problems which arise in connexion with ensuring that meat is produced under hygienic conditions (meat inspection). The principles involved in efficient controls of establishments and products are outlined. Technical progress in consumer protection is exemplified by the processes of pasteurisation, cooling and freezing, and the limitation of additives. Other important tasks arise in the disposal of animal carcasses and wastes, and in the fields of animal welfare and genetic engineering. Future activities in VPH will depend upon proper education, onward and postgraduate training for veterinarians, and suitable infrastructures for research, examination and surveillance.

Animals↗
PubMed1991

[Nutrition and consumer health protection].

Most individuals in our population consume healthy food. The conditions for doing so exist, i.e. an offer of a wealth of foods in the market. Yet there is still a need for joint action by science and research, food industry and government. When looking more closely, it will be seen that there are gaps in the health protection of the consumer: Wrong nutrition and overfeeding must be controlled by improved education. By doing so, it should be possible, at the same time to reduce the incidence of food-associated diseases such as cardiovascular diseases, cancer and metabolic disorders. While in this field of the protection of consumer health, so-called "visible" shortcomings of food intake are involved which can be influenced by nutritional medicine and the consumer, there are "hidden" ones if a contamination by infectious agents such as Salmonella bacteria or by chemical residues of e.g. heavy metals, pesticides, or additives is involved. This means that the consumer is unable to protect him/herself against the latter by his/her own means. For this reason, a particular responsibility has arisen for governmental authorities, to ward off risks arising from hidden shortcomings of food. A particular urgency has been found to exist for measures to eliminate pathogenic microorganisms from the food chain. Still, Salmonella bacteria are the most prominent target. There is a ratio of ca. 2/1 between salmonellosis and other forms of acute gastroenteric infections which are reportable under the Federal Communicable Diseases Act. On the whole, bacterial food poisoning is still on the rise, thus becoming the main problem of present-day control of communicable diseases. We should not be deceived by numerous improvements of technological and hygienic processes in the production of foods: in a long-term view, relief can be expected only from the creation of livestock which is free from infectious agents. Although a further reduction of chemical residues in certain foods has been achieved, it will remain a permanent task for government institutions to ensure that stipulated maximal amounts of foreign substances are not reached on a permanent basis and that, wherever possible, undesirable chemical residues are removed from the food chain. Cases of acute intoxication from chemical residues have remained single events. Nevertheless, there is a deficit of knowledge what concerns the toxicological and health evaluation of minimal levels of 1 microgram and less to which consumers have been exposed over years.(ABSTRACT TRUNCATED AT 400 WORDS)

Consumer Product Safety↗
PubMed1987

The future role of the veterinarian in the control of zoonoses.

Developments in the rearing and the health status of meat animals is presented. Attention is drawn to the increase in latent infections, most of which are zoonotic diseases. Such infections escape official ante-mortem and post-mortem inspection as it is presently conducted in industrialised countries, which still rely on the classical rules established by Robert von Ostertag. This examination is thus in need of reform. Proposals submitted to the EEC Commission consist of a stepwise inclusion of the major herds of meat animals in systematic health control aimed at effective control of zoonoses and thus improved consumer protection. It is thus expected that the importance of meat inspection on the basis of pathological-anatomical changes will decrease the importance of establishing the health status during the animal's lifetime will increase. Nevertheless, there will be no complete substitution of classical meat inspection because there are numerous changes in the meat specific to the individual animal which can be detected only by meat inspection, and must be detected if the concept of consumer protection is properly applied. The reform of meat inspection which has become necessary will entail a variety of new tasks for research.

Animals↗
PubMed1985

[Infection prevention in animal husbandry. A contribution to the improvement of the sanitary consumer protection].

The scientific and organizational development of an effective prophylaxis against infections in animal husbandry results from the fact that many zoonoses, like salmonellosis, campylobacteriosis, toxoplasmosis, leptospirosis, listeriosis, rickettsiosis (Q-Fever) and cysticercosis as well as certain important virus infections with regard to meat hygiene cannot be detected during official ante- and postmortem inspection. The cause of these infections is clinically inapparent and leaves no pathologic-anatomical lesions. Partly responsible for these latent infections is mass production with its specific forms of husbandry, particularly in poultry and pigs. The development of these animal production methods as well as the spread of the aforementioned zoonoses in man and animal is being discussed in this paper. The information on zoonoses is based on cases reported in accordance with the Federal Communicable Diseases Act and/or the regulations on notifiable animal diseases. The potential harmfulness to the consumer's health, especially in view of his food habits, is discussed in the light of the increase of foodborne infections and intoxications caused by Salmonella. Up until now, several regulations exist to keep causative agents of zoonoses away from animal farms. In view of the successful eradication of tuberculosis in cattle and brucellosis, it is recommended on a longterm basis, to eliminate those zoonoses from animal farms, which are of special importance from the meat-hygienic point of view. On a medium-term basis, examination of farm animals should be introduced voluntarily prior to the official ante- and postmortem inspection. It is of vital importance to establish the necessary diagnostic and practical conditions for the herd-tests. A recommendation worked out by the European Community for the examination of broiler-farms is welcomed as an example of prophylactic measures suitable for the improvement of consumer protection.

Animal Husbandry↗
PubMed1979

[Current zoonoses from the food hygiene point of view (author's transl)].

Of the numerous zoonoses part of which are reportable, according to the Federal Communicable Diseases Act, the food hygienist attributes topicality at present to salmonellosis, brucellosis, toxoplasmosis, taeniasis (T. saginata), trichinellosis, and sarcosporidiosis. In salmonellosis, combating is directed to breeding and keeping of Salmonella-free flocks, poultry offering favourable conditions for this purpose. Moreover, one tries to decontaminate feeds through certain pelleting machines with the aid of friction heat or by admixing propionic acid. In brucellosis, the possibility of infection by tourism, but also that through ingestion of imported dairy products (like soft cheese) play a certain role. Instruction of tourists and advising foreign labour from endemic areas are essential contributions to combating. Another important infection source of toxoplasmosis is infected raw pig meat. As the agent does not survive freezing temperatures under certain conditions, the decontamination procedure is particularly suitable. In pregnancy advising, the role of raw pig meat for development of congenital toxoplasmosis should be clearly explained. In trichinellosis, apart from the traditional examination by the trichinoscope, the modified digestion procedure using pepsin as a digestive fluid was successful. Moreover, it is suitable for detecting weakly infected swine. The importance of systematic examinations of all domestic and wild pigs became evident only recently in 1977, when in Bavaria an epidemic of trichinellosis occurred following the ingestion of undetected Trichinella containing wild pig meat. According to most recent knowledge on the cycle of development of sarcosporidia, the studies showed that the species Sarc. bovihominis and suihominis were pathogens for human beings. Quite apart from necessary supplementary examinations, the freezing procedure would here too, warrant an effective protection for the raw meat consuming population.

Animals↗
PubMed1978

The occurrence and importance of residues in meat and their evaluation within official meat inspection.

Food of animal origin is an important factor in protecting the consumer from health risks emanating from the environment. This is why chemical and drug residues in food animals have been included in the Meat Inspection Act in the Federal Republic of Germany. The following substances are subject to regulation: Drugs; Feed additives; Pesticides; Toxic substances from the environment. While drugs may give rise to resistance of infective agents to them, feed additives may accumulate in the organism and have a toxic effect. Pesticides themselves may not be harmful in the amounts, which accumulate in meat, however, their metabolic products in the human body may be toxic. Radioactive substances and radioactive fall-out as well as cadmium and mercury are dangerous when accumulating in meat. Therefor, fixation of tolerance levels for defined residues has been started to be set according to the new Foods Act, including their toxicological evaluation. Condemnation of organs of slaughter animals in which these chemicals accumulate is obligatory.

Animal Feed↗