Biomedical subjects
Publications and source records attributed to D Gryczyńska.
Ototoxicity of cisplatin is documented in during the last years. In material of 13 children with solid tumors (neuroblastoma, nephroblastoma, rhabdomyoscarcoma) treated with cisplatin, ototoxicity was observed in 2 cases. There were presented audiological findings. The role of otoacoustic emission measurements in monitoring of cisplatin--induced ototoxicity was underlined.
UNLABELLED: The cause of upper respiratory tract infections (URTI) are multifactorial (enlarged adenoid, environmental conditions, staying at the care centers, smoking parents, allergy). Directly, viral infection causes damage to the ciliary cells and mucociliary clearance in the nasopharynx and Eustachian tube, promotes tubal occlusion and provokes otitis media. Enlarged adenoids reduce ventilation to the nasopharynx, increase accumulation of the secretion and provide a good condition for bacteria. AIMS OF THE STUDY: Evaluation of the factors playing a role in recurrent URTI and otitis media in children. Clinical and histopathological examination of adenoid tissue of children who were passive smokers and children who were not exposed to cigarette smoke. Evaluation of the difference between ciliary-mucous transport among passive smokers and children not exposed to cigarette smoke. METHODS: The analysis of interview questionnaires in 1000 children aged 3-14 years. Histopathological examinations of adenoid tissue excised in the group of children of recurrent upper respiratory tract infections and serous otitis media exposed and not exposed to cigarette smoke. CONCLUSIONS: Among the risk factors for URTI, the most important are: (1) socio-economic conditions; (2) staying at day care centers; and (3) passive smoking. Allergy was confirmed in 35-38% of URTI children. Surgical treatment was undertaken in 11.4-32.5% of URTI children (tonsilloadenoidectomy). Histopathological and ultrastructural evaluation of adenoid tissue in passive smoking children indicates significant differences to children not exposed to cigarette smoke.
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The paper presents results of audiologic assessments hearing examinations in 19 children that received aminoglycosides in cases of pneumonias, meningitis and sepsis. Examination of hearing acuity with otoscopic assessment of the ears, tympanometry, ABR and acoustic otoemission were performed before, directly after infusion and after completion of treatment. After a laryngological examination and of the hearing acuity, tympanometry and the ABR the authors have concluded the normal state of the hearing organ. Only in the examination of the acoustic otoemission produced during the treatment it was found the amplitude was flattened or there was no otoeimssion for some individual frequencies in relation to records taken before the treatment. The authors emphasize that among risk factors of ototoxic effect of some medicines are of importance the following: patient's age, uncontrolled increase in blood drug concentration, increase in daily dosage, cumulation of the drug in the organism, prolonged treatment with the drug.
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Forty children with life-endangering tumors localized in the ENT region were treated during the last 10 years at two clinics in Poland: the Oncological Clinic in Warsaw and the Otolaryngological Children's Clinic in Lódź. In this group there were 29 malignant tumors at different pathology, and 11 non-malignant tumors that became life-endangering because of their size and localization. These children were treated, dependent on the nature of the tumor, with surgery, chemotherapy and X-ray therapy.
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