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Biomedical subjects

D Gutstein

Publications and source records attributed to D Gutstein.

7 recordsLinked to original sources
PubMed2002

Tissue factor deficiency causes cardiac fibrosis and left ventricular dysfunction.

Exposure of blood to tissue factor (TF) activates the extrinsic (TF:FVIIa) and intrinsic (FVIIIa:FIXa) pathways of coagulation. In this study, we found that mice expressing low levels of human TF ( approximately 1% of wild-type levels) in an mTF(-/-) background had significantly shorter lifespans than wild-type mice, in part, because of spontaneous fatal hemorrhages. All low-TF mice exhibited a selective heart defect that consisted of hemosiderin deposition and fibrosis. Direct intracardiac measurement demonstrated a 30% reduction (P < 0.001) in left ventricular function in 8-month-old low-TF mice compared with age-matched wild-type mice. Mice expressing low levels of murine FVII ( approximately 1% of wild-type levels) exhibited a similar pattern of hemosiderin deposition and fibrosis in their hearts. In contrast, FIX(-/-) mice, a model of hemophilia B, had normal hearts. Cardiac fibrosis in low-TF and low-FVII mice appears to be caused by hemorrhage from cardiac vessels due to impaired hemostasis. We propose that TF expression by cardiac myocytes provides a secondary hemostatic barrier to protect the heart from hemorrhage.

Animals↗
PubMed1994

Indications and advantages of laparoscopy-assisted colon resection for carcinoma in elderly patients.

The controversy about laparoscopy assisted colectomy for cancer is based on doubt about performing a radical resection and adequate histopathological staging. Therefore, we selected a group of patients who could profit from the accepted benefits of the technique, while avoiding its uncontrolled outcome. We operated on patients with colorectal cancer with distant metastasis and on patients over 70 years old and American Society of Anesthesia (ASA) III-IV with a high operative risk with standard surgery. The results for the first 18 patients demonstrated the following: (a) the size of the surgical specimen and the number of lymph nodes were similar to those in standard surgery; (b) no mortality and very low morbidity occurred despite the patients' advanced age, debilitated condition, and comorbid diseases; (c) minor postoperative complications occurred in five of 18 patients; (d) the hospital stay was 6-7 days for nonmetastatic patients and 9-12 days for metastatic patients; (e) the 1-year survey revealed a relapse in only one patient 9 months after the first operation.

Aged↗
PubMed1991

Adrenal cyst: a case report.

The authors describe the case of a patient with a large adrenal cyst. They review the existing literature and discuss the problem of diagnosis an treatment.

Adolescent↗
PubMed1989

[Diverticula of the small intestine. Presentation of 2 new cases and review of the literature].

Diverticuli of the small intestine are a rare, usually asymptomatic affectation. These diverticuli are acquired by pulsion and are the consequence of previous intestinal dyskinesia. Acute complications of jejunoileal diverticulosis are: diverticulitis, perforation, as in one of our cases, hemorrhage and obstruction; chronic complications are: megaloblastic anemia, malabsorption syndrome and steatorrhea. The preoperative diagnosis at the present poses great difficulties and surgical treatment is only indicated for complications.

Adult↗
PubMed1986

[Effect of glucagon on intestinal microcirculation].

Examinations in rats were carried out for investigating the glucagon effect on the bowel microcirculation. After intramuscular injection of glucagon an increase of the pO2, a decrease of the pCO2, and a consistent pH value were observed in the mesenteric vein. The results showed that by means of glucagon arteriovenous shunts of the bowel mucosa were opened. This leads to the exclusion of the capillary network in the villi.

Animals↗
PubMed1984

[Increase of bile acid reabsorption following total small intestine resection in the rat].

Bile salts undergo an enterohepatic circulation. The relative distribution of labelled cholic acid in portal blood, enterocytes, intestinal contents and feces, following intravenous injection of (carboxylic-14C) cholic acid, can be considered as an indication of the absorptive capacity of the epithelium cells. Seven days after a massive small intestinal resection (60-80 cm), the animal weight and the bile salt absorption were significantly decreased. Nevertheless, thirty days after the operation, weight and radioactivities reached the values found in the controls: in portal and cava blood, liver, intestinal contents and feces. An increase of the absorptive capacity of the intestinal epithelial cells was also observed.

Animals↗