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D H Barton

Publications and source records attributed to D H Barton.

102 records · Page 6Linked to original sources
PubMedDate not supplied

Evaluation of limonoids against the murine P388 lymphocytic leukemia cell line.

A structure/activity study of selected limonoids from two plant families (Meliaceae and Rutaceae) of the Rutales order against the murine P-388 lymphocytic leukemia system was undertaken. The presence of both a 19 leads to 28 lactol and a 14,15 beta-epoxide group was found especially important for pronounced inhibition of the PS in vitro cell line. Substitution of an A-ring alpha,beta-unsaturated ketone (3-oxo-1-ene) for the lactol led to diminished activity, while reduction of the olefin caused complete loss of activity. At the dose levels employed, even very good PS in vitro inhibition was not translated into PS in vivo antineoplastic effects.

Animals↗
PubMedDate not supplied

Use of a continuing health history in dental practice: a survey.

The authors strongly recommend the routine use of a continual-health-update procedure at each recall appointment. The updated health-histories allow us to better evaluate the "whole" child. We have found that the parent appreciates not only the initial inquiry, but also the continuing concern about illnesses and injuries the child may have incurred since the last dental examination. The inquiries help build rapport between the families and the professional staff of our office. In addition, they upgrade the level of professional care provided.

Child↗
PubMedDate not supplied

Dental attitudes and memories: a study of the effects of hand over mouth/restraint.

The purpose of this study was to document whether there was a significant difference in the number and severity of generalized fears and dental fears between patients who did and patients who did not experience hand-over-mouth and/or restraint as children. Patient records in a dental school children's clinic and a private pediatric dental practice were examined to identify patients who had experienced hand-over-mouth and/or restraint. A set of verbal questions was designed, tested, and used to ascertain the differences between the HOM/restraint group and the comparison group. One hundred twenty-two subjects were interviewed, 61 who had experienced HOM/restraint and 61 who had not. When compared for generalized fears and specific dental fears, the two groups showed no statistically significant differences (P = 0.86 and P = 0.36 respectively). No statistically significant difference appeared between the two groups when asked how they felt about visiting the dental office (P = 0.41). When three different formats were used to question the subjects relative to their early dental memories, the two groups showed no statistical difference in negative or positive responses (P = 0.38, 0.75, and 0.25 respectively). More than two times as many HOM/restraint subjects as comparison subjects described negative experiences in a physician's office or hospital. This difference was statistically significant (P < 0.01).

Adolescent↗