Biomedical subjects

D H Boyd

Publications and source records attributed to D H Boyd.

26 records · Page 2Linked to original sources

PubMed1975

Failure of resolution in pneumonia.

An account is given of the clinical, radiological and pathological features of 50 cases of pneumonia in which resolution was incomplete. This phenomenon occurs mainly in middle-aged and elderly men with chronic bronchitis and may simulate bronchial carcinoma. It most frequently affects the right upper lobe. Fibrosis and inflitration by chronic inflammatory cells are the characteristic histological abnormalities. Serious long-term sequelae are uncommon.

Age Factors↗

PubMed1975

Genes affecting coliphage BF23 and E colicin sensitivity in Salmonella typhimurium.

Rough strains of Salmonella typhimurium were sensitive to coliphage BF23. Spontaneous mutants resistant to BF23 (bfe) were isolated, and the trait was mapped using phage P1. The bfe gene in S. typhimurium was located between argF (66% co-transducible) and rif (61% co-transducible). The BF23-sensitive S. typhimurium strains were not sensitive to the E colicins. Cells of these rough strains absorbed colicin, as measured by loss of E2 or E3 killing units from colicin solutions and by specific adsorption of 125I-colicin E2 to bfe+ cells. Sensitivity to colicins E1, E2, and E3 was observed in a S. typhimurium strain carrying the F'8 gal+ episome. This episome complemented the tolB mutation of Escherichia coli. We conclude that the bfe+ protein satisfies requirements for adsorption of both phage BF23 and the E colicins. In addition, expression of a gene from E. coli, possibly tolB, is necessary for efficient E colicin killing of S. typhimurium.

Adsorption↗

PubMed1974