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D H Burke

Publications and source records attributed to D H Burke.

24 records · Page 2Linked to original sources
PubMed1978

Cobaltous choride-induced hypothermia in mice I: effect of pretreatment with anticholinergic drugs.

The hypothermic response following intraperitoneal doses (6.25, 12.5, and 25 mg/kg) of cobaltous chloride was investigated in Swiss albino mice. The magnitude and duration of rectal temperature depression were dose related. In each case, maximal hypothermia was evident within 30 min after injection. Body temperature depression was noted 30 min after oral, subcutaneous, intraperitoneal, intravenous, and intracerebral administration of cobaltous chloride. Cobalt was most active when administered intracerebrally, suggesting a central component to the thermolytic response. Rectal temperature depression following cobaltous chloride was dependent on the ambient temperature. The time course of the effect of cobaltous chloride on rectal and cutaneous tail temperature was noted. Cutaneous tail temperature depression occurred throughout the rectal temperature response, suggesting that cobalt may decrease heat production. Pretreatment with atropine sulfate, hexamethonium bromide, or nicotine failed to modify the temperature response to cobalt. Chlorpromazine hydrochloride pretreatment resulted in a partial antagonism of cobalt-induced hypothermia, presumably through a mechanism other than cholinergic blockade.

Animals↗
PubMed1977

Sodium nitroprusside-induced hypothermia in mice.

The hypothermic response following sublethal doses (1.25, 2.5, and 5 mg/kg) of sodium nitroprusside was investigated in mice. The magnitude and duration of rectal temperature depression were shown to be dose related. Oral administration of nitroprusside (5 mg/kg) failed to alter rectal temperature significantly; subcutaneous, intraperitoneal, intravenous, and intracerebral injections at the same dosage level caused respective drops of 3.61, 3.65, 6.44, and 3.48 degrees. The degree of rectal temperature depression following nitroprusside (5 mg/kg ip) was dependent upon the ambient temperature. The time course of the effect of nitroprusside (5 mg/kg ip) on tail temperature was noted. A transient rise in tail temperature, which coincided with the onset of rectal temperature depression, was attributed to the vasodilatory effect of the drug. Tail temperature depression occurred at the peak and throughout the remainder of the rectal temperature response, suggesting that nitroprusside may decrease heat production. Body temperature depression via intracerebral administration, as well as pronounced sedation following nitroprusside injection, suggests a central component to the thermolytic response.

Administration, Oral↗
PubMedDate not supplied

An integrated medical record system.

Clear, well-organized, thorough medical records are fundamental to the success of a quality healthcare organization. This article specifically addresses the problem of integrating multiple records from several group and individual practices into a single common medical record for each patient. All aspects of the record system are described--from initial development, record protocol, and start-up and operational costs, to implementation, quality control, and results of the new system. The information set forth is valuable to all healthcare administrations interested in establishing or maintaining integrated medical record systems in their group practices.

Group Practice↗