Plasma cell leukaemia relapsing in the dermis.
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Humans↗
Biomedical subjects
D H Pamphilon
Publications and source records attributed to D H Pamphilon.
The direct antiglobulin test in megaloblastic anemia.
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Anemia, Macrocytic↗
HLA antigens on red cells.
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Erythrocytes↗
Human cytomegalovirus infection and systemic lupus erythematosus.
OBJECTIVE: Viruses are considered possible aetiologic agents of autoimmune disease. Evidence suggests that human cytomegalovirus (HCMV) may be a pathogenetic factor in systemic lupus erythematosus (SLE). We undertook a seroepidemiological study to determine whether HCMV infection is increased in patients with SLE. METHODS: Sero-epidemiologic data, indicative of virus prevalence, were obtained by enzyme immunoassay. RESULTS: Eighty-eight of 97 serum samples (90.7%) taken from adult patients with SLE were seropositive for HCMV. By contrast, HCMV was detected in only 32 of 50 (64.0%) adult patients with rheumatoid arthritis (RA) and 42 of 97 (43.3%) normal controls. The odds ratio for HCMV prevalence in SLE/normal controls was 14.53 (95% CI is 6.39 to 33.04). For comparison, data for herpes simplex virus-I (HSV-I) seropositivity were obtained from the same three groups. Seventy-eight patients with SLE (80.4%), 40 patients with RA (80.0%) and 57 normal controls (58.8%) were seropositive for this closely-related herpesvirus. CONCLUSION: The data shows a specific and highly significant association between infection with HCMV and a clinical diagnosis of SLE.
Adult↗