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Biomedical subjects

D H Percy

Publications and source records attributed to D H Percy.

At least 91 records · Page 5Linked to original sources
PubMed1972

Experimental Brucella canis infection in the monkey (Macaca arctoides).

Four stumptail Macaque monkeys (Macaca arctoides) were each inoculated with approximately 10(10) organisms from a culture of Brucella canis. Two animals were inoculated via the oral and conjunctival route and the other two monkeys were inoculated intravenously with the organisms. A fifth animal served as a control. Blood samples were taken at weekly intervals for hematological, serological and bacterialogical studies. The monkeys were killed at five and ten weeks post-inoculation and tissues taken from a variety of organs for bacterial culture. B. canis was isolated from the peripheral blood of inoculated monkeys for up to seven weeks post inoculation and all infected monkeys developed significant neutralizing antibody titers to the organism. The bacterium was isolated from some tissues, including the uterus of one monkey, in the two animals killed at five weeks post-inoculation. Focal granulomatous lesions were sometimes observed in the liver, spleen and lymphoid tissue of inoculated monkeys. Such lesions are similar to those described in other brucella infections. Human infections with B. canis have occurred and the possible dangers entailed in exposure to the organism should again be emphasized.

Animals↗
PubMed1969

The histopathological changes in the skin of pigs with dermatosis vegetans.

Dermatosis vegetans, an hereditary disease seen in Landrace swine, is characterized by defects in the skin, and a giant cell pneumonia. Histological changes of the skin from 12 affected pigs of various ages were described. Lesions of the skin were characterized by acanthosis, hyperkeratosis, parakeratosis, and leukocytic infiltration. In general, the defects followed a definite developmental pattern, which were divided into three stages: (1) the stage of early development, (2) the intermediate stage characterized by an acute inflammatory response, and (3) the stage of regression. The specific role of the eosinophil, a prominent feature in this and other diseases of the porcine skin, remains obscure.

Animals↗