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Biomedical subjects

D H Spodick

Publications and source records attributed to D H Spodick.

At least 289 records · Page 16Linked to original sources
PubMed1983

Respiratory effects on systolic time intervals during pericardial effusion.

Pericardial effusion without cardiac tamponade is defined by the detection of excessive pericardial fluid without clinical manifestations, particularly pulsus paradoxus (inspiratory decrease in systolic blood pressure greater than 10 mm Hg) and jugular venous distention. Nineteen consecutive patients without heart or lung disease who had pericardial findings and no evidence of tamponade were investigated by echocardiography: 14 with pericardial effusion and 5 with noneffusive ("dry") pericarditis. Patients with effusion had an inspiratory decrease in left ventricular ejection time (delta LVET) of 17.9 +/- 5.78 ms and an increase in preejection period (delta PEP) of 12.1 +/- 3.78 ms, each well beyond the respective respiratory changes measured in normal subjects. The 5 control patients with dry pericarditis had a mean delta LVET and delta PEP of only 8.0 and 7.0 ms, respectively. Of the 14 patients with effusion, 6 whose systolic pressure showed no respiratory change had mean delta LVET of 13.7 ms and delta PEP of 11.2 ms, comparable to the other 8 patients with effusion who had a respiratory change of 2 to 10 mm Hg. We conclude that although pulsus paradoxus was not present, excessive pericardial fluid is not physiologically inert. If a satisfactory echocardiogram is not available, exaggerated respiratory fluctuation in systolic time intervals may be evidence of excessive pericardial fluid.

Blood Pressure↗
PubMed1983

Left ventricular performance during exercise: response of ear densitogram derivative.

The peak derivative of the ear densitogram (PD) has been shown to track left ventricular (LV) function during exercise. Measured as percent change in amplitude from resting control, PD in normal subjects slowly and consistently increased throughout exercise and to 2 minutes of recovery, followed by return to control level. In contrast, PD in patients with coronary artery disease rapidly increased only to 1 minute of exercise, with no significant subsequent increase. Expressed as a percent change from control, the response of normal subjects differs significantly from that of patients with coronary artery disease at 1 and 4 minutes of exercise, and 2 minutes of recovery. The PD increase in normal subjects from end-exercise to 2 minutes of recovery may be attributable to the heart rate decreasing faster than venous return, associated with LV ejection time, which is significantly shorter than heart rate-predicted values 2 minutes after exercise.

Coronary Disease↗