Biomedical subjects

D H Todman

Publications and source records attributed to D H Todman.

5 recordsLinked to original sources

PubMed1991

Colour duplex flow imaging in carotid arterial disease: correlation with intra-arterial digital angiography.

Colour duplex flow imaging is a highly accurate form of non-invasive assessment of the extra-cranial carotid circulation. This method is precise in characterising the degree of carotid stenosis, when compared with intra-arterial digital subtraction angiography. The accuracy of colour duplex in defining mild (1-30%), moderate (31-70%) and severe (71-99%) stenosis was 96%, 95% and 98%, respectively. Sensitivities and specificities were greater than 90% in each category, while positive and negative predictive values ranged from 96% to 100%.

Angiography, Digital Subtraction↗

PubMed1990

Pleuropulmonary fibrosis due to bromocriptine treatment for Parkinson's disease.

Pleuroplumonary fibrosis is an uncommon but potentially serious adverse effect of bromocriptine used in the treatment of Parkinson's disease. Two cases of this reaction, which occurred 12 months and 5 months respectively after commencing therapy are here reported. In both instances prompt clinical and radiological improvement occurred when bromocriptine intake was ceased. Fibrotic reactions to bromocriptine may be mediated by a serotonergic mechanism. Periodic monitoring of pulmonary symptoms is warranted in patients receiving bromocriptine treatment for Parkinson's disease.

Aged↗

PubMed1988

A paroxysmal ocular motility disorder in multiple sclerosis.

A 24-year-old woman with multiple sclerosis had frequent episodes of an ocular motility disorder and a crossed corticospinal tract deficit. This symptom complex illustrates a distinctive form of paroxysmal disorder in multiple sclerosis.

Adult↗

PubMed1984

Scapuloperoneal myopathy.

Two members of a family are described with muscle weakness and wasting affecting distal muscles of the lower limbs and muscles of the shoulder girdles. An autosomal dominant mode of inheritance is suggested with involvement of a 39-year-old female and her 15-year-old daughter. The disease in the mother has taken a relatively benign course with slow progression while the daughter has a short history of mild weakness. In both, the symptoms in the legs developed first, with foot-drop and a gait disturbance, and shoulder girdle weakness developed at a later stage. The facial muscles were mildly affected in the mother only. Results of electromyography and muscle biopsy in both these cases support a diagnosis of muscular dystrophy. The scapuloperoneal pattern of muscle involvement occurs in a number of pathological and genetic entities. The differential diagnosis includes scapuloperoneal syndrome with distal sensory loss in the limbs (Davidenkow's syndrome). The nosology of this disorder is discussed in relation to the cases presented.

Adolescent↗

PubMed1983

Encephalitis in infectious mononucleosis.

Three cases of infectious mononucleosis encephalitis are presented in which the aetiological diagnosis was established by specific Epstein-Barr virus serology. Paul-Bunnell-Davidsohn tests were negative in all cases, and characteristic nonneurological features of infectious mononucleosis were present in only one. The 3 cases had blood serological tests diagnostic of a recent infection with Epstein-Barr virus. The Epstein-Barr virus is one of the more common causes of sporadic encephalitis particularly in young patients and the diagnosis may be considered even in the absence of systemic features of mononucleosis. As there is a substantial false negative rate with the Paul-Bunnell test, confirmation of recent infection may be gained by specific viral serology.

Adolescent↗