Sleep apnea syndromes: a potential contraindication for patient-controlled analgesia.
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Biomedical subjects
Publications and source records attributed to D H VanDercar.
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Steady state exercise is widely used for psychophysiological studies in which a constant heart rate at a predetermined level is desired. We have developed a microcomputer servo-controlled bicycle ergometer system that can be used for administering steady state exercise. Fourteen healthy male subjects, with a wide range of fitness levels (measured by VO2max) were exercised to either a fixed workload (130 watts) or a predetermined heart rate level (servo-heart rate) of 122 bpm (i.e., 65% of maximum calculated heart rate for the sample). Servo-heart rate was implemented using a feedback loop that automatically adjusted workload to compensate for immediate variations in heart rate, resulting in a more consistent heart rate. Heart rate varied from the predetermined value by 17 bpm during fixed workload but only 3 bpm during servo-heart rate (p less than .05). Therefore, by using the microcomputer servo-controlled bicycle ergometer, heart rate was maintained at a predetermined level regardless of the subject's fitness level. VO2max and workload during servo-heart rate were significantly correlated (r = .85, p less than .05). Therefore, the workload necessary to maintain heart rate at a constant level may provide an approximate index of aerobic fitness level.
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This study was conducted to examine whether a central efferent pathway passing through the lateral zona incerta (LZI) of the subthalamus selectively mediates the bradycardia conditioned response (CR) in rabbits. Electrodes were implanted bilaterally in LZI or in control sites just dorsal or ventral to LZI. Two days following surgery, animals were subjected to Pavlovian conditioning or to pseudoconditioning. Subsequent bilateral electrolytic lesions did not influence the heart rate (HR) orienting response, unconditioned response, baseline, or lack of response to pseudoconditioning. Bilateral LZI lesions alone abolished the HR CR. In a follow-up experiment, the corneoretinal potential (CRP) CR and HR were recorded. Bilateral LZI lesions following conditioning to a criterion of 65% CRP CRs abolished the HR CR without affecting CRP CRs. The present findings indicate that LZI is part of an efferent pathway that selectively mediates the HR CR in rabbits.
A detailed description and analysis are presented of the psychological stress evaluator (PSE), an instrument purported to measure accurately and to portray graphically differential levels of stress in human speech. In addition, two studies are presented that attempt to validate this instrument against better known measures of stress or A-state anxiety. The PSE measures were compared with heart rate and State Trait Anxiety Inventory (STAI) A-state scores obtained under conditions where the level of stress was experimentally manipulated through threat of shock or the presentation of taboo words. The first study revealed that PSE, STAI, and heart rate measures accurately reflect different levels of stress and are significantly correlated with one another. The second study failed to replicate the validity of the PSE. This failure to replicate is attributed to lower levels of induced stress and a reduction in baseline measures of stress.
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