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D H Wright

Publications and source records attributed to D H Wright.

At least 145 records · Page 8Linked to original sources
PubMed1982

Malignant histiocytosis of the intestine: report of three cases with immunological and cytochemical analysis.

Tumour cells from three cases of malignant histiocytosis of the intestine (MHI) have been studied immunologically and cytochemically. The cells did not form E rosettes and showed weak Fc gamma surface receptors. They contained non-specific esterase and acid phosphatase in diffuse granular distribution. In one case tumour cells showed no staining by an immunoperoxidase technique with two monoclonal anti-T cell antibodies but positive staining with a monoclonal anti-Ia-like antibody. The malignant cells from all three cases could be shown to contain alpha-1-antitrypsin. These are the first cases of MHI to have been studied in this way and the results confirm the true histiocytic--that is, monocyte/macrophage, derivation of the tumour cells in this disease.

Aged↗
PubMed1981

Follicular center cell lymphoma of childhood: a report of three cases and a discussion of its relationship to Burkitt's lymphoma.

Three children with follicular center cell lymphomas are reported. The tumors were studied by light microscopy, electron microscopy, and the immunoperoxidase technique. All three tumors contained monotypic immunoglobulin; one had the morphology of a 'signet ring cell lymphoma,' and one had arisen in a child with Bloom's syndrome. Two tumors exhibited a nodular or partly nodular growth pattern. The tumors were compared with African cases of Burkitt's lymphoma and found to have marked differences in their morphologic and immunohistochemical characteristics. The authors believe that one should distinguish between Burkitt's lymphoma and follicular center cell lymphomas occurring in childhood.

Burkitt Lymphoma↗
PubMed1981

Angiolymphoid hyperplasia with eosinophilia simulating lymphadenopathy.

A case of angiolymphoid hyperplasia (AHE) with eosinophilia presenting with recurrent inguinal swellings simulating lymphadenopathy is described. Tissue was examined by light microscopic techniques, electron microscopy and immunohistochemistry. Electron microscopy showed large numbers of cytoplasmic filaments and bizarre Weibel-Palade bodies in the atypical endothelial cells that characterize AHE. Factor VIII related antigen was demonstrated in a small proportion of these cells by immunoperoxidase staining. The absence of staining for lysozyme and alpha 1 antitrypsin does not support the concept that these cells are histiocytic in nature. The prominent lymphoid and plasma cell proliferative elements in this case showed a polytypic staining pattern for immunoglobulin. An unusual reticular staining pattern for IgE was observed in the lymphoid follicles. The nature and pathogenesis of AHE is discussed in the light of previous publications and the findings in this case.

Adult↗
PubMed1981

Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): report of a case with widespread nodal and extra nodal dissemination.

A fatal case of sinus histiocytosis with massive lymphadenopathy (SHML) is described in a male patient who presented at 11 years-of-age with swelling of the malar region and nasal obstruction due to the disease and who died aged 28 in uraemic coma following renal involvement. At autopsy SHML tissue extended into the hilum of both lungs and from the retroperitoneal tissue into the pancreas and kidneys. The appearances suggest that the extension of the disease into these organs may have been due to retrograde lymphatic spread from involved lymph nodes. Replacement of the atypical sinus histiocyte by fibrous tissue was seen in the cervical lymph nodes and this may be the usual mode of resolution of the lesion. The nature of SHML is discussed in relation to a possible infectious aetiology and defects in the host immune system. Finally, it is noted that the term 'massive lymphadenopathy' is not applicable to all cases and that sinus histiocytosis in not appropriate for the now frequently recognized extranodal manifestations of the disease. It is proposed that the term 'lymphophagocytic histiocytosis syndrome' should be adopted or that the eponymous title 'Rosai-Dorfman disease' should be used.

Adult↗
PubMed1981

The mixed medical-psychiatric unit: an alternative approach to inpatient psychiatric care.

In a 256-bed general hospital, psychiatric patients are cared for on a single unit with medical patients. The unit, developed in collaboration with a state university's medical school, has been employed successfully in the teaching of psychiatric residents and medical students and has provided benefits to both the psychiatric and medical patients. A normalizing effect on the disturbed behavior of psychiatric patients has been observed and has been attributed to the presence of nonpsychiatric patients, and the treatment of medical patients on the unit has been humanized through greater nurse-patient interaction and the provision of activity programs and recreational facilities. The experience indicates that a wide range of psychiatric patients can be cared for in a mixed setting and that such a setting fosters continuity of care. The limitations of the unit and the policies and conditions necessary for its operation are discussed.

Hawaii↗
PubMed1980

Mechanism of the induction of angiogenesis by human neoplastic lymphoid tissue: studies on the chorioallantoic membrane (CAM) of the chick embryo.

The angiogenic activity of various neoplastic and control tissues, cells and extracts has been tested on the chorioallantoic membrane of the chick (CAM). The vascular response was assessed macroscopically and also by histological examination. Angiogenesis was induced by a number of neoplastic implants the most potent being derived from Hodgkin's disease, histiocytic lymphoma or glioma tissue. Boiled tumour tissue was ineffective. Lymphocytes extracted from human lymphomas, activated normal peripheral blood lymphocytes and established lymphoid cell lines of neoplastic origin were generally effective in inducing neovascularisation through millipore membranes as were 90,000-100,000 MW fractions of human tumour tissue. In all cases examined histologically a mononuclear cell infiltrate in the CAM mesoderm accompanied a positive vascular response. These results implicate host monocytes in the generation of neovascularisation by neoplastic tissue.

Allantois↗
PubMed1980

Mechanism of the induction of angiogenesis by human neoplastic lymphoid tissue: studies employing bovine aortic endothelial cells in vitro.

Extracts of human neoplastic tissue (three Hodgkin's lymphomas; three gliomas and one liposarcoma) previously shown to induce angiogenesis in vivo did not stimulate the proliferation of bovine aortic endothelial cell monolayers when tested in vitro. Proliferation was induced by coculture of endothelial cells with human or animal macrophages or with supernatants derived from these cells. However, angiogenic extracts were chemotactic both for guinea pig peritoneal macrophages and human mononuclear cells in vitro. These results imply that tumour extracts act indirectly to induce angiogenesis in vivo via their effect on host macrophages.

Angiogenesis Inducing Agents↗
PubMed1980

Adenocarcinoma of the pancreas of childhood: a report of two cases.

The clinical, gross anatomical, light microscopic and ultrastructural features of two cases of adenocarcinoma of the pancreas of childhood are presented and compared with adult carcinoma of the pancreas. Both tumours showed acinar differentiation and zymogen granules were demonstrated by electron microscopy. A limited immunohistochemical study suggests that staining for alpha 1-antitrypsin may provide a marker for acinar differentiation. The histogenesis of this tumour is discussed in relation to the possible origins of islet cells.

Adenocarcinoma↗
PubMed1980

The nature of the immunoglobulin-containing cells in malignant lymphoma: an immunoperoxidase study.

Using the immunoperoxidase technique, an attempt has been made to accurately characterize immunoglobulin (Ig)-containing cells in 185 cases of human malignant lymphoma. By applying a variety of antisera Ig synthesizing cells can be distinguished from cells taking up Ig from the environment. The use of thin (1 mu) paraffin sections has permitted detailed comparison to be made between Ig synthesizing cells of follicle center cell lymphomas and those of reactive follicle centers in human tonsils. Using cell pellets, similar comparison has been made with peripheral blood lymphocytes synthesizing Ig following stimulation with pokeweed mitogen. In follicle center cell lymphomas Ig synthesis is a function of cleaved and noncleaved follicle center cells, not plasma cells, and these cells are strikingly similar to Ig synthesizing cells normally present in nonneoplastic reactive follicle centers and the cells that synthesize Ig following pokeweed stimulation of peripheral blood lymphocytes. these results suggest pathways of B-cell maturation different from those commonly proposed and help to clarify certain inconsistencies in the classification of malignant lymphomas.

Histocytochemistry↗
PubMed1980

The Reed-Sternberg cell/lymphocyte interaction: ultrastructure and characteristics of binding.

Autologous T lymphocytes form broad, unspecialized, noninvaginating contacts with Reed-Sternberg cells in vitro. These differ from contacts between cytotoxic lymphocytes and their targets and from the uropodal type of lymphocyte adherence described in many antigen- (or mitogen-) dependent systems but show some resemblance to antigen-independent lymphocyte/macrophage contacts. Adherence is not confined to a specific T-cell subset; most adherent cells are negative for ANAE, Fc gamma, and Fc mu receptors. A minority have Fc mu or Fc gamma receptors or show ANAE staining. Adherence is dependent on divalent cations and intact surface proteins but is independent of temperature, cell metabolism, and intact microtubules and does not appear to be mediated by Fc gamma receptors or IgG. These characteristics distinguish it from immune T-cell/target-cell binding and from antigen-independent T-cell/macrophage or T-cell/B-lymphoblast binding. Contrary to previous suggestions, this interaction is not related to a cytotoxic attack. The lack of similarities with other lymphocyte adherence systems leads the authors to suggest that a unique receptor system is involved.

Cytotoxicity, Immunologic↗
PubMed1979

Primary gastrointestinal lymphomas: a classification of 66 cases.

Using routine histology, resin embedded sections and immunohistochemical techniques on formalin-fixed, paraffin processed tissue, 66 cases of primary gastrointestinal lymphoma have been classified. This study necessitated the development of reliable criteria to separate lymphomas of true histiocytic origin from those of lymphocytic origin. Among the morphologic properties of malignant histiocytes were complex pleomorphic nuclei, abundant well delineated cytoplasm and phagocytosis. These cells were shown to contain all major immunoglobulin chains, C3, lysozyme and in some cases alpha 1 antitrypsin. Malignant lymphomas derived from histiocytes could be divided into two groups: malignant histiocytosis of the intestine (MHI), a recently described diffuse pleomorphic lymphoma associated with villous atrophy of the small intestine, and histiocytic lymphoma (HL) which forms solid tumor masses in a similar manner to lymphocyte derived tumors. Immunohistochemical studies of lymphocyte derived tumors were negative apart from one case with plasmacytoid differentiation. Of the 66 cases, 50% were of histiocytic origin (33% MHI, 17% HL) and 41% of lymphocyte origin, there was one case of Hodgkin's disease and five cases were unclassified. The role of the histiocyte in gastrointestinal mucosa deserves further study.

Gastrointestinal Neoplasms↗