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Biomedical subjects

D H York

Publications and source records attributed to D H York.

At least 55 records · Page 3Linked to original sources
PubMed1967

The action of dopamine on neurones of the caudate nucleus.

1. Dopamine applied iontophoretically to neurones of the caudate nucleus of cats caused excitation of some (9% of those encountered) and depression of others (60%). Some cells have been found affected both by dopamine and by acetylcholine.2. The effects of dopamine could be prevented by the previous iontophoretic administration of phenoxybenzamine, but not by dichloroisopropylnoradrenaline.3. Responses evoked in caudate neurones by electrical stimulation of substantia nigra were depressed by dopamine. No evidence for enhancement of the effects of nigral stimulation through the application of dopamine were detected.4. Stimulation of nucleus centromedianus thalami depressed firing of caudate neurones.5. The hypothesis that dopamine may act as an inhibitory synaptic transmitter within the caudate is put forward.

Acetylcholine↗
PubMed1967

The inhibitory action of monoamines on lateral geniculate neurones.

1. L-Noradrenaline (NA), dopamine, 5-hydroxytryptamine (5-HT) and lysergide were administered iontophoretically to neurones in the dorsal lateral geniculate nucleus of the cat and the responses to these drugs recorded.2. Many neurones were depressed by the monoamines and lysergide.3. This depression was manifested by a reduction or abolition of the effects of optic nerve or visual stimulation, by a failure in some instances of an antidromically propagating spike to invade the cell soma, and by a depression of the excitant effects of L-glutamate and acetylcholine.4. Although there was considerable variation in the magnitude of the depressant effects of the monoamines, dopamine was found to be slightly more potent than 5-HT and NA. Neurones which were inhibited by catecholamines did not always respond to 5-HT and lysergide and vice versa.5. The inhibitory actions of monoamines on lateral geniculate neurones are comparable with those that have been recorded in other structures of the central nervous system.6. Lysergide did not antagonize the action of 5-HT.7. Catecholamines and 5-HT are present in nerve terminals in the lateral geniculate nucleus and the findings of this study suggest that they act as inhibitory transmitters.

Acetylcholine↗