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Biomedical subjects

D H Zhao

Publications and source records attributed to D H Zhao.

At least 37 records · Page 2Linked to original sources
PubMed1991

[Protective effects of nicorandil on myocardial mitochondria function during ischemia and reperfusion].

Experiment with recirculating blood perfusion device showed that nicorandil 0.15 mmol/L significantly counteracted the harmful effect of ischemic and reperfused injury on the respiratory function of myocardial mitochondria. The oxidative phosphorylation efficiency (ADP/O) was increased 19% (p less than 0.01), the respiratory control rate(RCR) was also increased 40% (p less than 0.01); while the content of myocardial calcium and Ca/Mg were decreased; and the ischemia and reperfusion-induced increase of myocardial water content was abolished as compared with solvent control. The results indicate that nicorandil has protective effect on myocardial mitochondria function during ischemia and reperfusion, which may be the result of blocking Ca2+ from entering the cell and prevent lipid peroxidation.

Animals↗
PubMed1991

[Protective effects of furyl-dihydropyridine I on ischemic myocardium in isolated rabbit hearts].

A recirculating nonpulsatile perfusion circuit was used in isolated rabbit hearts. Furyl-dihydropyridine I (2,6-dimethyl-4-furyl-1,4-dihydropyridine-3, 5-dicarboxylate) 20 mumol/L was shown to inhibit the release of creatine phosphokinase (CPK) and alpha-hydroxybutyrate dehydrogenase (HBD) from myocardium, decrease myocardial calcium and sodium contents by 5.3 +/- 1.1 mumol/g dry weight (P less than 0.01, n = 6) and 1.50 +/- 0.17 mmol/g dry weight (P less than 0.05, n = 6) from 8.3 +/- 1.1 mumol/g dry weight and 1.96 +/- 0.32 mmol/g dry weight respectively. It was also found to reduce coronary resistance and increase coronary flow of the ischemic myocardium, and prevent ischemic arrhythmia, thereby limit myocardial injury during regional ischemia in isolated rabbit hearts.

Animals↗
PubMed1990

[Protective effects of nicorandil on lipid peroxidation in ischemic and reperfused myocardium of rabbits].

The experiments of recirculating blood perfusion device showed that nicorandil (Nic) 0.15 mmol/L significantly decreased the content of malondialdehyde (MDA), inhibited the release of creatine kinase (CK), counteracted the increase of coronary vascular resistance (CR), and abolished the reperfusion-induced arrhythmias in isolated rabbit hearts during ischemia and reperfusion. The results indicate that Nic has protective effects on myocardial ischemic and reperfused damage, which may relate to the prevention of lipid peroxidation.

Animals↗
PubMed1990

[A program for analysis of dose-response relationship with logistic model].

In order to avoid the defects in common methods for analysis of dose-response curves, we fit groups of dose-response curves simultaneously or separately on computer by using logistic model, with the EC50 and slope factor as the basic parameters. The pD2 and pA2 values were calculated from the best estimated EC50s. This method shows a good compatibility with the original experimental data. The BASIC program can be conveniently run on microcomputers.

Animals↗
PubMed1989

[Effects of bis(dimethyl amino)-diphenyl methane (BDDM) on action potentials in guinea pig papillary muscle].

The effects of BDDM on action potentials and slow response action potentials in guinea pig papillary muscle were investigated by microelectrode technique. BDDM prolonged action potentials duration at 30, 50, 90, and 100% repolarization (APD30, APD50, APD90, APD100) and prolonged the effective refractory period (ERP), so ERP/APD value became greater. BDDM (51.6 mumol/L) decreased the APA, Vmax and prolonged APD50, APD90. In barium-induced ventricular autorhythmicity, BDDM suppressed the maximal diastolic potential (MDP), APA and reduced the rate of spontaneous rhythm. The results suggest that BDDM may unspecifically inhibit the currents of Ca2+, K+, and Na+.

Action Potentials↗
PubMed1989

[Clinical research on the relation of chronic gastritis and intragastric bile acids].

Intragastric bile acids on fasting for 1 hour have been determined by radioimmunoassay and thin-layer chromatographic scanning in 102 cases of chronic gastritis. The results showed that all of intragastric conjunction bile acids were higher in chronic atrophic gastritis group than those in chronic superficial gastritis group. Both of their intragastric bile acids and nitrite levels increased significantly in patients whose gastric mucosa appeared acute inflammation, glandular atrophy and moderate or severe intestinal metaplasia. These findings suggest that bile acids may be implicated in premalignant histological changes of gastric mucosa such as chronic atrophic gastritis. Determining intragastric bile acids will reflect the degree and injurious effect of duodenogastric reflux.

Adult↗