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Biomedical subjects

D Hairion

Publications and source records attributed to D Hairion.

6 recordsLinked to original sources

[Patentability of living material: public health concerns (1/2)].

A TOPICAL SUBJECT: The patentability of living material provokes debate in the scientific and medical world, but also concerns the political and legal circles. REGARDING PATENTS: Laws govern intellectual property rights and patients. There are contradictory arguments advanced by those who are in favour or who are opposed to patents, and particular problems related to the patenting of living organisms, particularly since the progress made in genomic research. ESSENTIAL PUBLIC HEALTH REQUIREMENTS: It is important to underline the limits imposed by the protection of intellectual property, regarding the access by all to any progress issued from research. The provisions must be widened in order to bypass the patents, when the health and nutrition of populations are at stake. It is essential to come to the universal accessibility, particularly in developing countries, to all innovations and that all knowledge be shared.

Animals↗

Vertical transmission of HIV--a rediscussion of testing.

It is worthwhile reconsidering the debate on mandatory or voluntary testing for HIV antibody among women of childbearing age, in the light of recent virological and therapeutic discoveries that have altered the parameters of the issue. The therapeutic possibilities of reducing the risk of transmission for women confirmed as seropositive are an incontestable benefit for anyone who is aware of her serological status; the fact of being able to detect real infection at birth could mean that causing unnecessary distress to the antibody positive but uninfected newborn infant is avoided. Medical professionals now have convincing arguments to persuade women at risk to accept the test when it is offered. But, in any case, the voluntary nature of the decision for testing must be respected.

AIDS Serodiagnosis↗

A new approach of brain tumors: the cytogenetic study.

Cytogenetic studies of brain tumors in adults have made it possible to determine specific chromosomal abnormalities and to detect a high incidence of gene amplification related to these abnormalities. Data from the literature and our own results show frequent numerical deviations in glioblastomas, such as gain of chromosome 7, but also 19, 20 and X, loss of certain chromosomes: monosomies 6, 14 and 22. Most of the structural abnormalities are deletions involving the chromosomal regions 1p, 6q, 7q and 9p, and the presence of double-minutes (DMs), the latter being the chromosomal expression of EGFR gene amplification. Cytogenetic analysis of meningiomas has shown that some of them have monosomy 22 alone while others have additional abnormalities. Antioncogenes probably play a part in these tumors. Their identification will explain the neuro-oncogenesis process and perhaps open a new route for the treatment of brain tumors.

Adult↗

[Research using the human embryo. A timely question].

There has been a considerable amount of debate in Europe on the use of the human embryo in research, a key point in the ongoing examination of bioethics laws. The French Academy of Medicine, the National Consultative Committee on Ethics, the State Council and the Parliamentary Office for the evaluation of scientific and technologic decisions have all made formal statements. An examination of these opinions discloses that there is a critical agreement concerning the Laws of July 1994 and on the requirement for a better text regulating research on the human embryo. It is becoming very clear that an international harmonization will probably not be possible on this point. In this context, where research on the human embryo is authorized in the United States, it is reasonable to expect fundamental discoveries which will be of fundamental importance for all scientific disciplines, emphasizing the need for further thought on our protectionist legal position.

Embryo, Mammalian↗