Biomedical subjects
D Harrison
Publications and source records attributed to D Harrison.
Influence of congestive heart failure on prazosin kinetics.
The kinetics of oral prazosin was studied in 10 healthy normal subjects (NS) and in 9 patients with congestive heart failure (CHF). NS received a single 5-mg dose, and blood concentrations of prazosin (CB) were measured, using a specific HPLC assay, during an 8-hr period. CHF patients received a 2-mg dose after which CB was measured for 10 hr. These patients then received 2 to 5 mg prazosin every 8 hr for 48 hr. After the last dose of prazosin, CB was measured for 24 hr. After the initial dose, time to peak CB did not differ significantly between that of the NS (123 +/- 19 SEM min) and of patients with CHF (132 +/- 31.3 min). AUC/mg prazosin was greater (p less than 0.001) in patients with CHF (3,385 +/- 380 Ng x min/ml) than in NS (1,603 +/- 208 ng x min/ml). Elimination of prazosin from blood was slower in CHF patients (t1/2 = 374 +/- 33.4 min) than in NS (t1/2 = 144.5 +/- 4.3 min) (p less than 0.001). These data suggest that in patients with CHF the elimination of prazosin is substantially slower than in NS and therefore higher steady-state prazosin concentrations can be expected in CHF patients than in NS.
Ribulose 1,5-bisphosphate carboxylase from autotrophic micro-organisms [proceedings].
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Vaccination against whooping-cough.
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Use of signal detection theory in examining the results of a contrast examination: a case study using the lymphangiogram.
The receiver operating characteristic curve is an unbiased technique useful for quantitating the extent to which varying modalities differ in their ability to identify pathological processes. It was applied specifically to a radiographic contrast examination--the evaluation of the lymphangiogram in patients with Hodgkin's disease.
The static and dynamic performance of a fluidic looped receiver pneumotachograph.
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