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Biomedical subjects

D Hebert

Publications and source records attributed to D Hebert.

At least 37 records · Page 2Linked to original sources
PubMed1999

Comparison of morphine patient-controlled analgesia with and without ketorolac for postoperative analgesia in pediatric orthopedic surgery.

The purpose of this prospective, randomized, double-blind, placebo-controlled clinical study was to determine whether the administration of intravenous ketorolac, coadministered with morphine patient-controlled analgesia (PCA), demonstrates an opioid-sparing effect, provides improved analgesia, and reduces the incidence of opioid-induced side effects in children after orthopedic surgery. The findings of enhanced analgesia with decreased opioid use suggest that coadministration of ketorolac with morphine PCA is beneficial for the treatment of pain in children after orthopedic surgery.

Adolescent↗
PubMed1998

Localization of persistent Enterocytozoon bieneusi infection in normal rhesus macaques (Macaca mulatta) to the hepatobiliary tree.

Enterocytozoon bieneusi is the most common microsporidian parasite recognized in human patients with AIDS. Recently, we identified a virtually identical organism causing a spontaneous infection associated with hepatobiliary and intestinal disease in simian immunodeficiency virus (SIV)-infected macaques. To examine the natural history of the infection, we examined captive rhesus macaques for E. bieneusi by PCR, in situ hybridization, and cytochemical techniques. PCR performed on fecal DNA detected enterocytozoon infection in 22 (16.7%) of 131 normal rhesus macaques (Macaca mulatta), compared to 18 (33.8%) of 53 rhesus macaques experimentally inoculated with SIV. In normal rhesus macaques, persistence of infection was demonstrated for up to 262 days and was usually not associated with clinical signs. In six of seven normal rhesus animals, E. bieneusi was detected by PCR in bile obtained through percutaneous cholecystocentesis but not by in situ hybridization performed on endoscopic biopsies of duodenum and proximal jejunum.

Animals↗
PubMed1998

Hand and foot growth failure in Rett syndrome.

Growth failure is a major aspect of the developmental arrest in Rett syndrome. Small hands and feet have been reported anecdotally, but the pattern of hand and foot growth has not been studied rigorously. The aims of this study were to characterize the hand and foot growth of 28 girls with Rett syndrome and to examine the relationship between their hand or foot size and height. Median hand length deviated to the 5th percentile at 11 years of age whereas median foot length and height deviated below the 5th percentile at 5.5 years of age. After adjusting for height-age, a greater proportion of foot lengths than hand lengths was less than the 50th percentile. In conclusion, the rate of hand and foot growth of girls with Rett syndrome is slower than that of the normal female. Moreover, the rate of deceleration of foot, but not hand, growth relative to height growth is greater. Thus, many girls with Rett syndrome have "small" feet, but not hands, for their height.

Adolescent↗
PubMed1995

A crossover comparison of extended release felodipine with prolonged action nifedipine in hypertension.

In a crossover design, control of blood pressure by extended release felodipine was compared with control by prolonged action nifedipine in 21 children with renal hypertension. Compliance with once daily felodipine was higher than with nifedipine, at 95.6 (SEM 2.7)% v 78.9 (6.0)% (p = 0.02). Mean diastolic blood pressure was lower during the day with felodipine than with nifedipine, at 77.6 (2.4) v 84.4 (2.8) mm Hg (p = 0.05). Similarly, blood pressure load (the percentage of the day during which the child had blood pressure exceeding the upper limits of normal for age) was lower for felodipine than for nifedipine: 43.5 (5.5)% v 61.3 (6.3)%. There was an opposite trend during the night, though this did not reach statistical significance. These data suggest that once a day felodipine is effective in children with hypertension. This may be because of improved compliance.

Adolescent↗
PubMed1993

[Chronic urticaria: evaluation and long-term follow-up].

Two major difficulties occur as soon as one is confronted to a patient suffering from chronic urticaria: the determination of an etiology that might be amenable to treatment and the establishment of an efficient treatment and satisfying follow-up for the patient. After having reviewed the different possible etiologies of chronic urticaria, this paper attempts to propose a logical diagnostic approach for the primary care physician. This will allow him to identify the etiologies that are the most common and responsive to a specific treatment and then to detail the modalities of this treatment.

Chronic Disease↗
PubMed1992

Rapid development of an immunoblastic lymphoma and death in children following cadaveric renal transplantation.

We report on three children who underwent cadaveric renal transplantation and subsequently developed an immunoblastic lymphoma, leading to death in two patients. The development of the lymphoma occurred following a multi-drug immunosuppression regimen ending with monoclonal antilymphocyte (OKT3) treatment for biopsy-proven cellular and vascular acute rejection. These patients represent three of 11 children who received OKT3 treatment for rejection in the last 18 months at this institution. Following the diagnosis of lymphoma, all three patients were treated by transplant nephrectomy, cessation of immunosuppression, and administration of intravenous acyclovir. The first two patients died at 4 days and 4 weeks, respectively, after the definitive diagnosis was made with widespread metastatic disease. The remaining child is a short-term survivor (13 months), free of demonstrable malignancy. Multidrug regimens for immunosuppression have a profound effects on T cell function. These effects, when combined with a primary infection by the Epstein-Barr virus, are implicated in the rapid development of the lymphomas and are responsible for the death of these two children.

Cadaver↗
PubMed1992

Immunomorphometric studies of proteinuria in individual nephrons of rats.

BACKGROUND: Heterogeneity of proteinuria among nephrons has been directly shown by micropuncture analysis of experimental models. Since the number of nephrons per kidney that are accessible for micropuncture is very small, we have developed a new immunomorphometric method for directly studying proteinuria in a much larger number of individual nephrons. This new method is based on the luminal surfaces of thick ascending limb of the loop of Henle (TAL) cells collectively functioning as an immunoabsorbent column for anti-Tamm-Horsfall protein antibodies that enter the urinary filtrate of that nephron. EXPERIMENTAL DESIGN: The distribution of luminal IgG deposits formed in TALs after injection of anti-Tamm-Horsfall protein antibodies was studied in three models of experimental proteinuria in rats to define the relationship between the formation of luminal deposits and the overall level of albuminuria and to test the utility of this method in analyzing the heterogeneity of luminal deposits among nephrons in other models. RESULTS: A close relationship between the magnitude of albuminuria and the distances that luminal IgG deposits extended along the straight course of TALs in individual nephrons of rats injected with rabbit anti-Tamm-Horsfall protein antibodies was established in a model of proteinuria with a uniform pattern of glomerular hemodynamics, heterologous immune complex nephropathy in rats. In models with more heterogeneous glomerular hemodynamics, autologous immune complex nephropathy and aminonucleoside nephrosis, greater heterogeneity in luminal IgG deposit formation among nephrons was demonstrated. The distances that luminal IgG deposits extended along TALs was more variable in these models than in heterologous immune complex nephropathy rats with comparable levels of albuminuria. CONCLUSIONS: Variability in the distances that luminal IgG deposits extend along TALs reflects heterogeneity among nephrons. The luminal deposit technique provides a new means for direct analysis of variability of dysfunction in many individual nephrons not accessible to micropuncture.

Animals↗
PubMed1991

Simple renal cysts in children: diagnosis and follow-up with US.

To assess the sonographic frequency of simple renal cysts in children, the authors retrospectively reviewed the results of abdominal sonographic studies of 16,102 children performed over a 5-year period between January 1, 1985, and December 31, 1989. Patients with abnormal renal function, dysplastic kidneys, or a family history of polycystic kidney disease were excluded from the study. The authors' review of the sonograms revealed 37 simple cysts in 35 patients (0.22%); the cysts were evenly distributed by age and sex and measured from 0.3 to 7.0 cm in maximum diameter. Sixteen cysts (43%) were in the upper pole of the right kidney. Follow-up sonographic studies of 23 cysts in 22 patients for up to 5 years showed no change in size in 17 cysts (74%). The largest cyst was drained percutaneously; all other cysts were managed conservatively. No patient showed deterioration of renal function. Therefore, the authors concluded that in a pediatric patient demonstrating normal renal function, no further intervention is necessary when a simple renal cyst is identified at sonography.

Adolescent↗
PubMed1982

Similarities of the cataleptic state induced by beta-endorphin and morphine.

A variety of behavioral tests were used to characterize the cataleptic state induced by various treatments. Besides catalepsy, posture, locomotion, rigidity and the presence of reflexive responses were assessed. Measures of analgesia and body temperature were taken. The behavioral profiles of beta-endorphin, morphine, etonitazene, haloperidol, arecoline and GABA were compared at the time maximal catalepsy scores were obtained. Results indicated that, for an equivalent degree of catalepsy, the profile of beta-endorphin was similar to that of opiates, except for changes in body temperature; beta-endorphin's profile differed markedly from that of haloperidol, arecoline and GABA. Catalepsy was less pronounced with the latter two drugs. There were similarities in the behavioral profile of haloperidol and arecoline.

Analgesia↗
PubMed1981

Behavioral toxicity of chronic administration of fenitrothion in rats.

A battery of tests was used to assess the neurobehavioral effects of fenitrothion in doses of 10, 20 and 40 mg/kg administered daily to rats for a period of 40 days. Decreases in body weight, overt cholinergic signs, loss of many reflexes, changes in measures of motor activity and, later, indices of ataxia were observed at various times after onset of treatment with the two higher doses of fenitrothion. Mortalities occurred within 12 days in those groups but all signs of toxicity and of behavioral deficits disappeared gradually in survivors. Changes in the neurobehavioral measures were seen in only two of the animals treated with 10 mg/kg and only after more than 20 days of treatment; in one rat, weight loss, absence of some reflexes, deficits in activity and signs of ataxia preceded death by several days. Results are discussed in relation with the existing data on the behavioral toxicity of fenitrothion.

Animals↗