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Biomedical subjects

D Heinrich

Publications and source records attributed to D Heinrich.

32 records · Page 2Linked to original sources
PubMed1976

[The pattern of distribution of free amino acids in human amniotic fluid related to the duration of pregnancy. Part I: Changes in concentration in normal pregnancy (author's transl)].

Gas-chromatographic measurement of 18 free amino-acids from about 500 specimens of amniotic fluid between the 10th and 41st week of pregnancy. Statistical methods showed different concentrations of amino-acids in amniotic fluid during pregnancy. Serine, cysteine, methionine and tryptophane show constant concentration. Valine tyrosine and hydroxyproline continuously decrease. The other amino acids tested here show a biphasic course of concentration, falling by about 40-70% between the 10th and the 30th week after which they remain stable. Alanin, threonine, glycine and ornithine show a clear increase of concentration. This diversity of concentration of amino-acids during pregnancy hints at the importance of various factors for the composition of amniotic fluid.

Alanine↗
PubMed1975

Evidence of platelet complement-fixing and lymphocytotoxic anti-A-1 antibodies.

3 human antisera exhibiting non HL-A specific antibody were studied in micro-complement fixation with platelets and micro-lymphocytotoxicity. Screening studies as well as absorption and elution studies with platelets, lymphocytes and erythrocytes revealed an antibody activity associated with blood group A-1. Within blood group A-1, a subpopulation of A-1 donor cells- provisionally called "weak A-1" - was defined, which had a minor ability for complement-fixing and lymphocytotoxic A-1-antibody absorption. Contrary to HL-A specific antibodies, acid eluates from platelets of these 3 sera were always negative whereas heat and ether eluates gave positive results. From neutralization studies and studies on the hemolytic activity against A-1 erythrocytes it was concluded, that the A-1-specific antibodies probably are immune antibodies belonging to the IgG class of immunoglobulins.

Absorption↗
PubMed1975

[Differences in concentration of free amino-acids in fetal and maternal compartments at the end of normal and pathologic pregnancies (author's transl)].

Free amino-acids in the fetal and maternal compartments towards the end of normal and pathologic pregnancies were examined with gas chromatography. Blood was obtained from the cubital and uterine veins and the femoral artery of the mother, from the umbilical artery and vein and the amniotic fluid during Caesarean section. There were only minor differences of concentration of free amino-acid between normal and pathologic pregnancies. Since it is possible in principle that there is mutual balance between maternal and fetal compartments, assessment of changes in amino-acid concentration during dia- and paraplacentar exchanges is usable only with reservations.

Amino Acids↗