Biomedical subjects
Publications and source records attributed to D Hellín Meseguer.
We describe the modification in one of the passages of the technique of subtotal laryngectomy with epiglottoplasty, consisting of the opening of larynx through the thyroid membrane. This maneuver improves the visualization of the tumor facilitating the time of its removal and later reconstruction.
A histochemistry study by means of lectins of vomeronasal organ or Jacobson's organ was performed in 5 Wistar rats. Vomeronasal organ is localized at the antero-inferior level of the septum and present two kinds of epithelium, an olfactory one and other respiratory, on the medial and on the lateral part, respectively. Olfactory epithelium shows a great reactivity to WGA lectin, moderate to PNA and weck to Con-A and SBA. In the respiratory epithelium the reactivity is moderate to DBA, PNa, SBA and WGA lectins for goblet cells, instead the periciliary sheat of mucus is reactive to all lectins but DBA and LTA.
An histochemistry study with lectins was performed in the epiglottis and cricoid cartilages of 4 Syrian golden hamsters (Mesocricetus auratus). The results show that there are differences in glycoconjugates between both cartilages. In the epiglottic matrix there was no reactivity to HPA, PNA and DBA lectins. However the cricoid cartilage showed no reactivity to SBA. Neither of cartilage matrixes were reactive to LTA or Con-A.
A histochemical study, with lectins, in oropharyngeal cavity of 5 Syrian golden Hamsters (Mesocricetus auratus) was performed in order to know the tongue submucous glands characteristics. Results showed a strong reactivity to HPA lectin for secretions of submucous glands of the Hamster's tongue and a slight reactivity to N-WGA and to WGA lectins.
The paper deals about classical histologic and histochemical study for mucinoid substances through 7 laryngeal pieces coming from clinic autopsies. The gland units occurring in the two lower thirds of the epiglottis were formed by a great number of serous acini and mucinous tubuli, which secretion is acid and neutral mucous substances, as sialomucins, serving as lubricant and protective means. This glandular system convey through the epiglottic perforans holes, without break, the pre-epiglottic and epiglottic spaces, with the clinical repercussion that suggest the chance of encroachment for incipient epiglottic cancer to pre-epiglottic room.
We have performed, with light microscope, a study about the distribution and morphology of the subepithelial glands of the hamster's larynx. The results are: at the base of the tongue the great deal of the glands are mucous, at the epiglottic base seromucous and at the subglottic space (at the level of cricoid cartilage) serous.
An histologic study was performed by light microscopy of the rat nasal cavity. A neuroepithelial lining is found in the backside of the cavity and the medial portion of vomeronasal organ. A respiratory seudostratified epithel with a great deal of submucous glandulae cover the remainder of the cavity.
Histochemical studies done with lectins are helpful for differentiate between several carbohydrates and glycoproteins of cell structures. Mast cells predominate in the nasal polyps mucosa of these patients. Cytoplasmic granules of mastocyts reacted to all lectins employed but LTA.
We have performed an histochemical study with lectins of normal nasal mucosa in 6 patients admitted at Hospital because an abdominal pathology, and other 6 with nasal polyps. Results showed a similar reactivity to lectins of excretory duct cells of seromucous glandulae of basement membrane of normal nasal mucosa and the analogous cells of the nasal polyps mucosa.
We have performed an histochemical study with lectins of the normal nasal mucosa of 6 patients. These patients were admitted at the Hospital for abdominal surgery. A wide biopsy was taken of the inferior nasal turbinate mucosa. The results show a different reactivity between the serous and mucous cells of the submucosal glands and with the goblet cells. We have not found reactivity to DBA, SBA and LTA lectins.
We describe a typical case of eosinophilic ulcer of the oral mucosa (EUOM) after an adverse reaction to carbamazepine, in a manic-depressive patient. This case may be suggestive of other etiologic factors for the EUOM, different to traumas.
We present a case of cavernous laryngeal hemangioma in an elderly lady. The limited surface of the lesion and its location and implantation basis as well allowed an endolaryngeal surgery.
In order to know the differences between the submucosal glands and the goblet cells of the supraglottic mucosa, a lectin histochemistry study was performed in 4 larynx of hamster (Mesocricetus auratus). The results show a strong reactivity to HPA and N-WGA lectins in the submucosal glands. Also reactivity to N-PNA and UEA-1 was present in the submucous glands but not in the goblet cells.
A histochemical study with lectins of the olfactory epithelium of 5 Wistar rats was performed. This neuro-epithelium cover the postero-superior part of the nasal cavity and the medial part of the vomeronasal organon. There are numerous Bowman's glands in the olfactory epithelium, besides the sensory cells. These glandulae dye as well with PAS.AB, the same as the mucosal layer over the epithelium, which show its composition on sialo-sulfomucines. The mucous layer over the olfactory epithelium shows a great reactivity to WGA, moderate to PNA and Con-A and weak to SBA. On the other hand Bowman's glands show an intense reactivity to PNA and moderate to WGA, VEA-I and to Con-A.
An histochemistry study, with lectins, of the nasal mucous membrane of 5 Wistar rats, was performed by the AA. A pseudostratified respiratory epithelium with plenty submucosal glands cover the nasal cavity. Results show than goblet cells are reactive to DBA, PNA, SBA and WGA. The periciliary mucus layer is reactive to all lectins but DBA and LTA. Maxillary glands react to WGA and Con-A. Septal glands are also reactive to WGA and Con-A and furthermore to SBA.
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The effect of inferior nasoantral windows on mucociliary clearance, with or without radical surgical removal of the maxillary sinus mucosa, was evaluated in five New Zealand white rabbits. Mucociliary clearance was analyzed using India ink as a marker and observing its distribution and flow rate. Partial and radical surgical removal of the mucosa, nasoantral windows, and the Caldwell-Luc operation were performed and mucociliary transport was studied. After three months, mucociliary clearance was conserved after partial resection of the sinus mucosa and absent after radical mucosal resection.
In ten albino New Zealand rabbits we studied in the regenerated mucosa of the maxillary sinus what happens after three months of radical removal of sinus mucosa. The study was realized by light and electronic microscopy, with special attention to the plasma cells around the submucosal glands. There is an increased of plasma cells, in a proportion of 10:1.