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Biomedical subjects

D Hendel

Publications and source records attributed to D Hendel.

At least 37 records · Page 2Linked to original sources
PubMed1999

Isolation and hormonal responsiveness of primary cultures of human bone-derived cells: gender and age differences.

We present a model for isolating human cell culture derived from biopsies obtained during orthopedic surgery. Four donor groups were defined by gender and age: pre- and postmenopausal women (<50 and >55 years, respectively), and younger (30-55 years) and older (>60 years) men. Bone-derived cells were identified as osteoblasts by major osteoblastic characteristics; that is, high alkaline phosphatase (ALP) activity, dose-dependent increase of ALP by 1,25(OH)2D3, high levels of parathyroid hormone (PTH)-induced cyclic AMP, and 1,25-(OH)2D3-induced osteocalcin. In all cells, levels of osteocalcin were significantly elevated (p < 0.05 and 0.01). In cells derived from men, no significant age differences were found in ALP and osteocalcin values of basal activity and in fold stimulation 1,25(OH)2D3. Cells from postmenopausal women showed a nonsignificant lower basal ALP activity than premenopausal cells. In postmenopausal cells, ALP responded less to 1,25(OH)2D3 (33% increase, p < 0.05) than the premenopausal cells (100% increase, p < 0.05). In cells from either age group, ALP did not respond to the gonadal steroids 17beta-estradiol (E2) and dihydrotestosterone (DHT) or progesterone. Basal levels of osteocalcin were higher in cells of premenopausal origin as compared with postmenopausal cells (p = 0.05), but response to 1,25(OH)2D3 was the same. PTH significantly stimulated cAMP (p = 0.001) in all age and gender groups analyzed. In all groups, no differences were found in either basal activity or in PTH response. Unlike men, cells derived from the bone of women were more susceptible to age changes. We postulate that the postmenopausal cell population had a decreased number of osteoblasts, or cells in a lower differentiation stage. These results extend our knowledge of bone biology found in animal models and reveal that human osteoblasts from men do not show the same age-dependent differences observed in women.

Alkaline Phosphatase↗
PubMed1998

[Rupture of pectoralis major muscle: operative treatment of an uncommon sport injury].

Rupture of the pectoralis major muscle in an athlete is rare, but is said to be common in weight lifters. The muscle usually ruptures at the musculotendinous junction during forceful contraction of the muscle in adduction, forward flexion and internal rotation of the arm. We describe an athlete who suffered such a major tear during a rugby game. It was treated surgically and after adequate rehabilitation, athletic activities were resumed.

Adult↗
PubMed1997

[Recurrent late hemarthrosis after total knee replacement].

A patient who had a successful total knee replacement for severe degenerative osteoarthritis of the right knee had an excellent functional result. 2 years after the operation there was spontaneous intra-articular bleeding that was treated successfully conservatively. Recurrent hemarthrosis 2 months later was treated similarly and also resolved without residual functional impairment after a follow-up of over 1 year. Recurrent late hemarthrosis in the knee is a fairly rare complication following total knee arthroplasty, but is amenable to conservative measures. Frequently, persistent recurrent hemarthrosis requires debridement of the bleeding synovium of the knee.

Hemarthrosis↗
PubMed1997

Intra-articular tibial plateau stress fracture associated with osteoarthrosis and valgus knee deformity.

Severe valgus deformity of the knee secondary to osteoarthritis can predispose to stress fracture of the lateral tibial plateau. Described herein is a case of severe valgus knee deformity that was complicated by an intra-articular tibial plateau stress fracture and treated by a fully constrained Guepar hinge prosthesis with a satisfactory end result. The etiology and mechanism of this complication are discussed, with emphasis on the diagnostic process.

Aged↗
PubMed1994

Changes in femur dimensions in asymptomatic non-cemented hip arthroplasties. 20 cases followed for 5-8 years.

We assessed changes in proximal femur diameter during 5-8 years follow-up of 20 clinically successful press-fit cementless isoelastic implants. Total bone diameter, medullary diameter and cortical thickness were measured over the distal half of the prosthesis and just beyond the prosthesis tip. During the follow-up period total bone diameter did not change. However, cortical thickness declined by an average of 1 mm, while the size of the medullary canal increased by the same amount. As the patients remained asymptomatic during this period, the phenomenon observed did not appear to be related to loosening. We concluded that age-related changes in bone diameter can lead to widening of the tight interface between the stem and the femur.

Adult↗
PubMed1993

Arthroscopic adhesiolysis of the knee joint in arthrofibrosis.

Arthroscopically assisted adhesiolysis is a relatively new method for the treatment of arthrofibrosis of the knee. It is as effective as other known techniques and has the advantage of being minimally traumatic to the joint and the surrounding soft tissues. The operative method is presented here, together with three case reports of patients representing part of a series of 10 patients treated in our ward by arthroscopic adhesiolysis. Results, which were very favorable--average flexion improved 72 degrees and average extension improved 12 degrees--were stable over time, and all patients were pain-free at follow-up. Our experience supports previous positive reports concerning this additional mode of treatment for arthrofibrosis.

Adolescent↗
PubMed1992

The use of the transpillar posterolateral approach to resect cervical osteoid osteomas: operative technique and results.

Osteoid osteomas located in the cervical spine are a rare cause of cervical and shoulder pain. However, successful diagnosis of these tumors has become more frequent in the recent years. This is due to more available diagnostic modalities as well as to physician awareness of the possibility that such lesions can cause cervical pain syndrome. Resection of osteoid osteomas located close to the vertebral artery is often technically difficult, and poses significant risk to the patient. We describe resection of such tumors using a posterolateral transpillar approach in three patients. The advantage of this approach is the direct and relatively easy visualization of the tumor, without the need for an extensive dissection. The stability of the cervical spine is not compromised by this approach. However, extension of the operative field is difficult, should the need arise.

Cervical Vertebrae↗
PubMed1989

An overlapping pubic dislocation treated by closed reduction: case report and review of the literature.

An overlapping dislocation of the symphysis pubis is a rare injury caused by either side-to-side compression or hyperextension. We hereby describe a case of such injury sustained during parachuting and reduced by closed means. This case appears to be the first described in the literature where no damage to the urogenital tract was observed. The patient is asymptomatic 1 year later.

Adult↗
PubMed1989

Multicentric giant-cell reparative granuloma. A case in the foot.

A case of multicentric giant-cell reparative granuloma in the foot of a 17-year-old boy is reported. Initially, there was a calcaneal lesion and 6 months later, three additional lesions in the forefoot. The calcaneal lesion was treated by curettage and bone grafting, and those in the forefoot by wide excision. The patient has now been free of disease for 18 months.

Adolescent↗