PubMed Health⌕ Search

Biomedical subjects

D Holdaway

Publications and source records attributed to D Holdaway.

10 recordsLinked to original sources
PubMed2000

Intellectual, neuropsychological, and academic functioning in long-term survivors of leukemia.

OBJECTIVE: To assess the effects of treatment for acute lymphoblastic leukemia (ALL) on children's cognitive functioning. METHOD: Participants were long-term survivors of ALL treated with cranial irradiation and central nervous system (CNS) chemotherapy (n = 20), or CNS chemotherapy only (n = 21), healthy children (n = 21), and children with chronic asthma (n = 21). The groups were compared on measures of intellectual, neuropsychological, and academic functioning. RESULTS: CNS chemotherapy, with and without cranial irradiation, was associated with significantly lower levels of intellectual and academic functioning. Children with chronic asthma obtained lower scores than healthy controls, but these differences were not significant. Tests of neuropsychological functioning did not consistently separate the groups. CONCLUSIONS: CNS chemotherapy and, to a lesser extent, chronic illness both contribute to the poorer performance of long-term survivors of ALL on measures of intellectual and academic functioning.

Achievement↗
PubMed1998

Treatment of acute asthmatic exacerbations with an increased dose of inhaled steroid.

OBJECTIVE: To investigate the efficacy of an increased dose of inhaled steroid used within the context of an asthma self management plan for treating exacerbations of asthma. DESIGN: Randomised, double blind, placebo controlled, crossover trial. METHODS: Twenty eight children aged 6-14 years with asthma of mild to moderate severity were studied for six months. Eighteen pairs of exacerbations were available for analysis, during which subjects took an increased dose of inhaled steroids or continued on the same dose. RESULTS: There was no significant difference between increasing inhaled steroids or placebo on morning or evening peak expiratory flow rates (PEFRs), diurnal peak flow variability, or symptom scores in the two weeks following an asthma exacerbation. Difference (95% confidence intervals) in baseline PEFR on days 1-3 were 3.4% (-3.5% to 10.4%) and -0.9% (-4.7% to 2.9%) for inhaled steroid and placebo, respectively. Spirometric function and the parents' opinion of the effectiveness of asthma medications at each exacerbation were also not significantly different between inhaled steroid or placebo. CONCLUSION: This study suggests that increasing the dose of inhaled steroids at the onset of an exacerbation of asthma is ineffective and should not be included in asthma self management plans.

Acute Disease↗
PubMed1997

Application of asthma action plans to childhood asthma: a national survey.

AIM: To determine the frequency of asthma action plan use by doctors in the management of childhood asthma in New Zealand, and their recommendations about the application of an increased dose of inhaled steroids in those plans. METHODS: A postal survey was sent to all 236 paediatricians and paediatric registrars and to a random sample of 500 general practitioners (GPs) in New Zealand. Questions related to asthma action plan use, the inclusion of an increased dose of inhaled steroid in those plans and details of the way the inhaled steroid dose is adjusted. RESULTS: Valid responses were received from 168 (71%) paediatricians and paediatric registrars and 340 (68%) GPs. The majority (92.6%) of GPs and paediatricians and paediatric registrars used action plans and 83.6% included a step involving an increased dose of inhaled steroids. Compared with paediatricians and paediatric registrars, GPs gave action plans to a smaller proportion of asthmatic children in their care and included an increased dose of inhaled steroid more often (GPs = 94.5%, paediatricians and paediatric registrars = 57%). CONCLUSION: In New Zealand the use of asthma action plans is inconsistent with the recommendations contained in published consensus documents in that not all asthmatic children are advised about an action plan. Specific issues relating to this and to the use of an increased dose of inhaled steroids in action plans require clarification and further research.

Administration, Inhalation↗
PubMed1997

Measles control.

Explore the source record for details and available documents.

Humans↗
PubMed1981

Wheezing bronchitis in children on a South Pacific Island.

Retrospective and prospective studies were done on children with wheezing bronchitis on the small Pacific island of Niue. Wheezing bronchitis was found to be a common cause of morbidity, but not mortality in these children. Episodes of the disease were most common in children under the age of 4 years and tended to disappear as they became older. A case-control study indicated smoking by the mother (P less than 0.0001), positive stool examination for parasites (P less than 0.001), mother with a history of wheezing bronchitis (P less than 0.01) and father smoking (P less than 0.05) were all correlated with wheezing bronchitis. Skin testing and serologic results indicated that hypersensitivity to house dust mite (Dermatophagoides pteronyssinus) and plantain (Plantago lanceolata) antigens were also associated with having wheezing bronchitis. This study demonstrates the multifactorial etiology of wheezing bronchitis on a Pacific island.

Adolescent↗