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Biomedical subjects

D Hollanders

Publications and source records attributed to D Hollanders.

14 recordsLinked to original sources
PubMed1987

Gastritis and gastric campylobacter-like organisms in patients without peptic ulcer.

Gastric biopsy specimens were obtained from 83 patients without peptic ulcer disease and analysed histologically. Culture and serological studies were done on the last 64 patients. The patients were divided into two age groups (young and old groups.) In 34 patients with chronic superficial gastritis, gastric campylobacter-like organisms (GLCO) were identified histologically in 91% and grown on culture in 88%: antibody to GCLO was detected in 81%. No age-related difference in the prevalence of the organism was demonstrated. In the 23 patients with atrophic gastritis (all elderly), presence of the organisms appeared to be related to the presence of an inflammatory cell infiltrate into the gastric mucosa. These figures for the prevalence of the organism in this selected group of patients are similar to those reported in previous studies of unselected patients which included those with peptic ulcer. This suggests that GCLO is unlikely to be causally related to peptic ulcer.

Adult↗
PubMed1986

Twice daily tripotassium dicitrato bismuthate in the treatment of duodenal ulceration.

Fifty three patients with endoscopically proven duodenal ulceration have cooperated in a clinical trial to compare the ulcer healing effect of tripotassium dicitrato bismuthate (TDB) at standard dosage administered either twice or four times daily. No statistically significant difference has been found to exist between ulcer healing in the two groups at 4 weeks (72% and 67%, P = 0.944) or at 8 weeks (92% and 81%, P = 0.504) and it is concluded that twice daily TDB maintains the effectiveness of the drug and has advantages for patient compliance.

Adolescent↗
PubMed1986

Sensorineural deafness--a new complication of ulcerative colitis?

A case of sudden bilateral sensorineural deafness associated with active ulcerative colitis is reported. Evidence for an autoimmune basis for this condition is reviewed and the potential benefit of systemic corticosteroids emphasized. The condition may represent a recently recognized extra-intestinal complication of ulcerative colitis.

Adolescent↗
PubMed1981

Difference in relapse rates of duodenal ulcer after healing with cimetidine or tripotassium dicitrato bismuthate.

In a double-blind randomised trial in 75 patients with duodenal ulceration diagnosed endoscopically, 38 patients were given tripotassium dicitrato bismuthate and 37 cimetidine. There was no significant difference in the healing rates between the two drugs after 1 and 2 months, although relief of symptoms was marginally quicker with cimetidine. During follow-up for at least a year, relapse was significantly more common in patients whose ulcers had healed during treatment with cimetidine than in those whose ulcers had healed during treatment with tripotassium dicitrato bismuthate. This difference appears to be related to the medication rather than to any other difference between the two groups of patients. These results suggest that drug treatment given for a short period in duodenal-ulcer disease influences the progress of the disease.

Adolescent↗
PubMed1976

Serial liver biopsies in blood donors with persistent HBs antigenaemia.

Initial liver biopsies from asymptomatic HBs antigen positive blood donors showed a range of histological abnormalities ranging from minor parenchymal lesions to cirrhosis. Twenty of these have now been followed up for periods of up to four years and during that time have had at least two liver biopsies. Throughout the period of study all the donors have remained carriers of HBs Ag, and there was no significant variation in the titers of antigen or the electron microscopic appearances of the serum in individual donors. The histological appearances of subsequent liver biopsies were not always the same as those seen initially, and while there appeared to be some improvement in three cases, there were nine in which the histological appearances were worse.

Adult↗
PubMed1970

Recurrent ulceration after vagotomy and drainage with electrical stimulation test, 1957-69.

Between 1957 and 1969 700 patients with duodenal ulceration were treated by selective vagotomy and simple drainage using the electrical stimulation test to achieve complete nerve section. Ten of these patients have been re-admitted to the hospital with further ulceration, one with a lesser curve gastric ulcer and nine with recurrent duodenal disease. The first patient had gastric retention and has apparently been cured by gastrojejunostomy to improve antral drainage. The remaining nine cases were found to have incomplete nerve section, and, of these, seven have been treated and apparently cured by completion of the incomplete vagotomy, again using the electrical stimulation test.

Adolescent↗
PubMed1969

Selective vagotomy without drainage. An interim report.

The results of surgical treatment for duodenal ulcer were compared in two groups of patients-51 who had undergone selective vagotomy without drainage and 17 who had had selective vagotomy and pyloroplasty. It is suggested that in the absence of organic pyloric or duodenal stenosis the former method seems both preferable and desirable, since postoperativley dumping does not occur and there is a steady improvement in gastric emptying.

Dumping Syndrome↗