PubMed Health⌕ Search

Biomedical subjects

D Houssin

Publications and source records attributed to D Houssin.

At least 253 records · Page 14Linked to original sources
PubMed1985

Effects of hyperthermia on normal or neoplastic rat liver.

An experimental study was conducted in rats to evaluate the sensitivity of the liver to infrared hyperthermia. A 15-min hyperthermia session treating only the liver was done in rats with a normal hepatic parenchyma and in rats with hepatocarcinoma induced by chronic 3'-diethylaminoazobenzene intoxication, at various ranges of intrahepatic temperature. In normal rats, 40-42 degrees C hyperthermia was well tolerated, but the mortality rate increased when the intrahepatic temperature exceeded 42 degrees C. In rats with tumors, a 40-42 degrees C hyperthermia session was well tolerated in case of small tumors, but resulted in a high mortality rate in case of large tumors. In all cases, death occurred as a consequence of liver injury. This study using a simple method of hyperthermia defines the thermosensitivity of the neoplastic or normal rat liver and provides a basis for further investigations on the effect of hyperthermia on experimental liver tumors.

Animals↗
PubMed1985

[Hepatocellular carcinoma in a non-cirrhotic liver. Anatomo-clinical study of 22 cases of hepatectomy. Histo-prognostic factors].

The present clinicopathological study concerns 22 cases of hepatocellular carcinoma in non cirrhotic liver; they all underwent hepatectomy performed in the same surgical unit, and this group is clinically homogeneous. This cancer shows higher frequency in males (17/22), and in ages between 40 and 72. No etiologic relevance is shown. An abdominal mass is detected as first clinical symptom. Macroscopically: the tumor most often appears as a chief nodule 2-4 cm in diameter surrounded by smaller ones, always in close proximity. Histologically: the tumors are usually well or rather well differentiated hepatocarcinomas; 4 of them are fibrolamellar. Because of these macroscopical features and because of the absence of metastasis at the time of laparotomy even in case of recurrence, partial hepatectomy seems justified. A rich reticulin framework and its even distribution seem to be the best morphological signs indicating good prognosis. Long lasting survival, exceeding 11 years for one patient, concerns chiefly fibrolamellar tumors.

Adult↗
PubMed1984

[Tolerance to hepatic allografts].

Several experimental data suggest that, compared with other organs, the liver has a privileged status as concerns rejection. In fact, in pigs and rats, spontaneously tolerated liver allografts have been observed with, in rats, constitution of a state of donor-specific transplantation tolerance. Hyperacute rejection, which is a complication of organ allografts in some immunological situations, has not been observed after liver transplantation. In man, acute rejection of liver allografts usually is easily controlled by the immunosuppressive treatment. However, in some cases, an irreversible chronic rejection may occur.

Animals↗
PubMed1984

Hepatic arterial embolization for malignant hypercalcemia in hepatocellular carcinoma.

A patient who presented with hypercalcemia was found to have an hepatocellular carcinoma. Medical treatment failed to normalize blood calcium levels. Liver resection was not feasible due to major extrahepatic involvement. Selective arterial embolization of the tumor was performed, resulting in correction of the hypercalcemia. This observation suggests that some life-threatening complications of unresectable hepatocellular carcinoma can be treated by arterial embolization of the tumor.

Carcinoma, Hepatocellular↗
PubMed1984

[Brain-death unit and renal transplantation. Evaluation of 5 years' experience].

From 1977 to 1982, 170 potential organ donors were referred to "a brain-death unit". A vast majority of these patients were provided by intensive care units of district general hospitals from Ile-de-France. This fact confirms the dispersion of potential organ donors and the usefulness of an organ-procurement structure based in an University Hospital. Its effectiveness is demonstrated by an harvesting rate of 58%, largely over the already published reports in case of absence of such a center. It is concluded that the adoption of this system by other hospitals would significantly increase the number of cadaver kidney grafts available for transplantation whereas actually the number of kidney grafts remains dramatically low in France.

Adolescent↗
PubMed1984

Transplantation of hepatocytes for treatment of surgically induced acute hepatic failure in the rat.

Efficacy of transplanted hepatocytes was evaluated in rats with a surgically induced acute hepatic failure. After 75% liver resection and portacaval shunt, the intrasplenic or intraperitoneal injection of 20 million isolated fresh hepatocytes was shown to significantly reduce the mortality rate. These results confirm that the transplantation of isolated hepatocytes may prevent death in rats with acute hepatic failure, and suggest that hepatocyte transplantation acts by a mechanism of hepatic support.

Acute Disease↗
PubMed1984

Reduced-sized orthotopic liver graft in hepatic transplantation in children.

Because of the rarity of child donors, in cases of adult donors room requirement for the liver graft is a major technical obstacle to liver transplantation in children. To overcome this difficulty in a child, the authors performed an orthotopic transplantation with an adult liver that had been reduced to the left lobe. The absence of technically-related complications suggests that this procedure might facilitate the performance of liver transplantation in children.

Body Weight↗
PubMed1983

Evaluation of isolated human hepatocytes.

This preliminary study reports the functional capacities of freshly isolated human hepatocytes in regard to their energetic metabolism and monooxygenase activities. Incubated for 30 or 60 min, isolated cells maintain their membrane integrity, ATP and reduced glutathione content and redox potential estimated by means of lactate to pyruvate and beta-hydroxypyruvate to acetoacetate ratios. Three monooxygenase activities, supported by different isoenzymes of cytochrome P-450 are determined by the accumulation of unconjugated metabolites: their relative magnitudes are similar to those observed in microsomes, indicating a good preservation of hydroxylase activities during cell isolation and incubation. Although incubations did not exceed 60 min, one can conclude that human hepatocytes maintain their viability and metabolic capacities after isolation and might be considered in transplantation process for the treatment of acute hepatic failure. Isolated human hepatocytes might be also used as a tool for studying biochemical and toxicological effects of a drug.

Adolescent↗