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Biomedical subjects

D I Armstrong

Publications and source records attributed to D I Armstrong.

11 recordsLinked to original sources

A new suite of programs for external beam radiotherapy isodose planning based on the RAD8 method.

A suite of programs is outlined which develops the ideas of the popular RAD-8-based approach to computerized RT treatment planning, but which uses real-space geometry throughout its algorithms. This, together with a higher level of modularity and complete documentation, enables other users of the software to understand the programs and adapt them to their special treatment methods. In addition, a number of new planning features are incorporated as useful options.

Computers↗

Thyroid vascularity--documentation of the iodide effect in thyrotoxicosis.

Thyroid vascularity was measured in 101 thyrotoxic patients by analysis of 99mTc pertechnetate thyroid flow studies obtained with a gamma camera--minicomputer system. The diffusely hyperplastic goitres tended to have higher vascularity than the toxic multinodular goitres, and many of the solitary toxic nodules had vascularity results within normal limits. Potassium iodide therapy, 60 mg b.d. for 10-14 days results in a dramatic reduction in thyroid vascularity in diffuse thyroid hyperplasia and toxic multinodular goitre but the effect on toxic nodules was marginal.

Humans↗

Computer-assisted thyroidal technetium uptake measurement using a short pinhole-to-surface distance.

The close pinhole view of the thyroid presents some important measurement problems. Possible errors due to gland, neck and set-up geometry are accentuated due to the effects of the inverse square law, and care is needed to control these. The nonuniform response inherent in the use of the pinhole collimator has a significant effect, but with computer processing this is readily eliminated. ENR subtraction may become difficult in certain circumstances, as insufficient "background areas" may be viewed, but it has been shown that the use of a "universal" (for the particular system) ENR subtraction may give, if anything, more accurate results. With these precautions in use, important errors will be of the same order of magnitude as those involved in more distant views, and may thus be kept within the realms of clinical significance. On the other hand, considerable improvements in both resolution and sensitivity make the use of the closer view an asset to both the research laboratory and the small department involved mainly in routine service work.

Computers↗