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Biomedical subjects

D I Jones

Publications and source records attributed to D I Jones.

At least 19 recordsLinked to original sources
PubMed1986

"Patient demand" postoperative analgesia with buprenorphine. Comparison between sublingual and i.m. administration.

A randomized, double-blind, placebo-controlled study of buprenorphine was carried out in 20 patients after cholecystectomy. The drug was given on "patient demand" either i.m. (0.15 mg) or sublingually (0.2 mg) with a minimum dose interval of 30 min. Over the 24-h study period the mean demand by the sublingual route was 0.8 mg (range 0.6-1.2 mg) and by the i.m. route 0.66 mg (range 0.45-0.9 mg). Pain relief, by visual analogue scales and grading, was similar. Plasma buprenorphine concentrations varied more after sublingual administration. Either route was effective for the treatment of pain when administered by "patient demand".

Administration, Oral↗
PubMed1977

Self-poisoning with drugs: the past 20 years in Sheffield.

In Sheffield there are now over 1000 admissions to hospital each year because of self-poisoning, an increase of twentyfold over the past two decades. The city is representative of the Trent Region, and it can be confidently estimated that there are at least 100 000 cases of self-poisoning in the United Kingdom each year. Most patients are in their late teens and early twenties, and in young women self-poisoning is the most common cause of emergency admission to a medical ward. Although the drugs are usually prescribed by a doctor, patients, especially the young, are showing an increasing tendency to misappropriate drugs prescribed for others. The choice of drug is a matter of simple availability, and national trends in prescribing are reflected in the overdose figures. Barbiturates and paracetamol are responsible for the most deaths. Residence in densely populated areas may be a predisposing factor.

Adolescent↗
PubMed1968

The metabolism of 3,5-di-tert.-butyl-4-hydroxytoluene in the rat and in man.

1. The major metabolites of 3,5-di-tert.-butyl-4-hydroxytoluene (BHT) in the rat are 3,5-di-tert.-butyl-4-hydroxybenzoic acid (BHT-acid), both free (9% of the dose) and as a glucuronide (15%), and S-(3,5-di-tert.-butyl-4-hydroxybenzyl)-N-acetylcysteine. 2. The mercapturic acid does not appear to derive from the usually accepted enzyme mechanism, and may involve a non-enzymic reaction between BHT free radical and cysteine. 3. The ester glucuronide and mercapturic acid found in rat urine are also the major metabolites in rat bile and must be responsible for the enterohepatic circulation. 4. Free BHT-acid is the main component in rat faeces. 5. In man, BHT-acid, free and conjugated, is a minor component in urine, and the mercapturic acid is virtually absent. The bulk of the radioactivity is excreted as the ether-insoluble glucuronide of a metabolite in which the ring methyl group and one tert.-butyl methyl group are oxidized to carboxyl groups, and a methyl group on the other tert.-butyl group is also oxidized, probably to an aldehyde group. 6. These differences in metabolism by the rat and by man are sufficient to account for the difference in excretion by the two species.

Animals↗