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Biomedical subjects

D I Rudenko

Publications and source records attributed to D I Rudenko.

11 recordsLinked to original sources
PubMed1996

[The effect of interleukin-2 on interferon production by human lymphocytes and the importance of this test in autoimmune diseases].

Interleukin-2 (IL-2) was demonstrated to induce interferon (IFN) production in the cultured lymphocytes from healthy donors and myasthenia gravis (MG) patients. Moreover, IL-2 enhanced lymphocytic IFN production in patients and healthy individuals in response to phytohemagglutinin and concanavalin A. However, in MG patients, IFN production in response to IL-2 alone or in combination with mitogens is several times lower than that in healthy donors. This lowered IFN production in MG patients is accompanied by much higher rates of lymphocytic proliferation and by considerably enhanced spontaneous lymphocytic production of C-reactive protein as compared with healthy individuals. This test may be of great value in establishing the diagnosis of an autoimmune disease, in defining its severity and in evaluating the efficiency of therapy.

Autoimmune Diseases↗
PubMed1995

Clinical variability of facioscapulohumeral muscular dystrophy in Russia.

One hundred forty-two patients (66 men and 76 women) from 20 autosomal-dominant pedigrees and 3 families including 5 "sporadic" cases were examined. A great similarity of clinical manifestations among those affected was noted. Clinical variability of phenotypes reflecting various phases of the disease and different expressions of the mutant gene were always within the limits of the identical final phenotype of the disease, namely the facio-scapulo-humero-peroneal-femoro (posterior group of the muscles)-gluteal (gluteus maximus). Thus, the clinically and genetically homogeneous group of patients with autosomal-dominant descending with a "jump" form of facioscapulohumeral dystrophy (FSHD), called facioscapuloperoneal dystrophy (FSPD), was examined. Among the observed cases we did not come across any having the autosomal-dominant gradually descending form of FSHD, called facioscapulolimb dystrophy (FSLD), in which the pelvic and proximal lower limb muscles get weak earlier than in the peroneal group (anterior tibial) muscles. We could not reveal the "pure" facioscapulohumeral phenotype of muscle weakness in 142 examined patients. A "pure" FSHD does not exist as a nosological entity. It represents only the syndrome which characterizes the initial phase of FSLD, but not of the FSPD. It is quite probable that FSPD and FSLD which may be differentiated clinically are two different diseases connected with the mutation of allelic or even different genes. Linkage studies in FSPD and FSLD mapping genes would confirm this data.

Adolescent↗
PubMed1991

[Laser correlation spectroscopy of the blood serum in assessing the efficacy of hemosorption with myasthenia patients].

In 30 patients with myasthenia the authors studied the dynamic of changes of subfraction content of the blood serum using the method of laser correlation spectroscopy. Significant changes of the blood serum homeostasis have been revealed in the process of hemosorption. The obtained results make it possible to develop objective criteria for indications to hemosorption as well as for the assessment of the efficacy of therapy.

Adolescent↗
PubMed1990

[Indicators of lipid peroxidation and erythrocyte membrane permeability in patients with myasthenia gravis].

Twenty-five patients suffering from myasthenia with no thymectomy were examined for lipid peroxidation (LPO) and erythrocytic membrane permeability. A study was also made of spontaneous and induced LPO, the level of diene conjugates and permeability of the erythrocytic membranes in mixtures of isotonic urea and sodium chloride solutions of varying volumetric concentrations. LPO activation which was coupled with an increase of erythrocytic membrane permeability was revealed. The data obtained point to the impairment of membrane apparatus function in patients with myasthenia and allow recommending the use of the membrane-stabilizing therapy.

Adolescent↗
PubMed1990

[Myasthenic crises].

The authors analyze the course of myasthenia complicated by the development of the myasthenic crisis, provide the data obtained over the recent 5 years by the clinic of nervous diseases of the Leningrad Institute of Advanced Medical Training, review the causes leading to the development of the myasthenic crisis, its clinical manifestations, discuss the problems of the diagnosis and treatment.

Adult↗
PubMed1990

[Lambert-Eaton myasthenic syndrome in bronchogenic carcinoma].

Six patients with Lambert-Eaton myasthenic syndrome were analyzed for the character of the initial symptoms, the clinical course and typical lesions on electrophysiological and x-ray studies. The given myasthenic syndrome often anticipates tumor symptoms and patients, as a rule, are seen for a long time by neuropathologists with a diagnosis of myasthenia. The data of ours indicate a real opportunity of the use of neurological and electromyographic criteria for goal-oriented search of bronchogenic carcinoma at the earlier stages of its development.

Action Potentials↗
PubMed1990

[The characteristics of the oxygen-transport function of hemoglobin in myasthenia patients].

A study is presented of the oxygen-transport function of hemoglobin in 50 patients suffering of myasthenia. Age of the patients: from 18 to 70 years. The patients showed increased level of the erythrocytic 2,3-DPG which is a sensitive index of the state of tissue oxygenation and changes of the kinetics of oxygen by hemoglobin. The obtained results permit to evaluate the mechanisms of development of respiratory insufficiency in patients with myasthenia, favours adequate assessment of the severity grades of the disease, help to plan pathogenetic treatment.

2,3-Diphosphoglycerate↗
PubMed1990

Comparison of HLA antigen spectrum in atherosclerosis of various localization.

The spectrum of HLA antigens was studied in 619 control subjects and 357 patients with atherosclerosis of various localization (coronary, cerebral, and lower limbs arteries). Comparative analysis has shown both agreement and differences to exist between patient groups depending on atherosclerosis localization. Significant differences were also found in the level of various lipid components. A relationship between HLA antigens and lipid markers was demonstrated, especially between locus B and C antigens and HDL cholesterol level. The authors believe the findings can be utilized to determine predisposition to atherosclerosis of various localization.

Adult↗
PubMedDate not supplied

[Electromyography in the evaluation of the functional state of the internal neuromuscular apparatus of the larynx in myasthenia].

Using needle transcutaneous electromyography of internal laryngeal muscles and kalymin tests, 40 patients with myasthenia of different forms were examined. It was found that patients with generalized and local pharyngeal-facial forms of the disease developed latent generalization of myasthenic injury. Characteristic changes can be used to determine the degree of disorders in the internal nervous-muscular apparatus of the larynx.

Adolescent↗